DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant4 and Galnt9

DIOPT Version :9

Sequence 1:	NP_001137779.1	Gene:	Pgant4 / 261610	FlyBaseID:	FBgn0051956	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_938048.2	Gene:	Galnt9 / 231605	MGIID:	2677965	Length:	604	Species:	Mus musculus

Alignment Length:	666	Identity:	209/666 - (31%)
Similarity:	321/666 - (48%)	Gaps:	113/666 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAIKKRYVKRLLRKVVLLLVVIVTVSLVTTL---------VV---ERRMKNAAELTEQLDPNGDP 53
            ||:.:: :|.||...:|:.|.|:..|:...|         ||   :|||:|
Mouse     1 MAVARK-IKTLLTVNILVFVGIILFSVYCRLQDRSEALVQVVRGTDRRMRN-------------- 50

  Fly    54 ITPVFRAANIHPTRKAPRPPFQDRNSVVDIPRSDKLQGFRLPEPKGERKDWHDYAAMEADRKRSG 118
                         |.:......||.::  :.|.|.|:.....:..|..|   ....:|..   .|
Mouse    51 -------------RLSKASALADREAI--LQRLDHLEEVVYNQLNGLAK---PIGLVEGP---GG 94

  Fly   119 FGEHGVAVKIENPDEKQLEKEHYEMNGFNGLISDRISVNRSVPDLRLEACKTRKYLAKLPNISVI 183
            .|:.|||..::  |:.|..:..:|..|:|..:|||||::|::||.|.:.|:...|...||.|||:
Mouse    95 LGQGGVAATLQ--DDSQETEGKFEDFGYNAQLSDRISLDRTIPDYRPKRCRQITYSEDLPQISVV 157

  Fly   184 FIFFNEHFNTLLRSIYSVINRTPPELLKQIVLVDDGSEWDVLKQPLDDYVQQHFPHLVTIVRNPE 248
            |||.||..:.:|||::||:|.||.:|||:::||||.|:...||..||.||.:.:|.||.:|||..
Mouse   158 FIFVNEALSVILRSVHSVVNHTPSQLLKEVILVDDNSDNVELKFNLDQYVHKRYPGLVKVVRNSR 222

  Fly   249 RQGLIGARIAGAKVAVGQVMVFFDSHIEVNYNWLPPLIEPIAINPKISTCPMVDTISHEDF---S 310
            |:|||.||:.|.|||...::.|||:|:|.|..|..|.:..|..:.:....|.:|.|.:..|   .
Mouse   223 REGLIRARLQGWKVATAPIVGFFDAHVEFNTGWAEPALARIQEDRRRIILPAIDNIKYSTFEVQQ 287

  Fly   311 YFSGNKDGARGGFDWKMLYKQLPVLPEDALDK---SMPYRSPVMMGGLFAINTDFFWDLGGYDDQ 372
            |.|     |..|::|. |:....:.|:|.||:   |.|.|:|.|:|..|.::.::|.|:|..|..
Mouse   288 YAS-----AAHGYNWG-LWCMYIIPPQDWLDRGDESAPIRTPAMIGCSFVVDREYFGDIGLLDPG 346

  Fly   373 LDIWGGEQYELSFKIWMCGGMLLDVPCSRVAHIFRGPMKPRGNPRGHNFVAKNHKRVAEVWMDEY 437
            ::::|.|..||..::|.|||.:..:||||||||.| ..||..|...: :..:|..|.||||||::
Mouse   347 MEVYGAENIELGMRVWQCGGSMEVLPCSRVAHIER-TKKPYNNDIDY-YAKRNALRAAEVWMDDF 409

  Fly   438 KQYVYK--RDPKTYDNLDAGDLTRQRGVRERLKCKSFHWFMTEVAPDFLVKFPPVEPPSYAAGII 500
            |.:||.  ..|.|...:|.||::.:..:||:|||:||.|::..|.|:.     .:...:...|.:
Mouse   410 KSHVYMAWNIPMTNPGVDFGDVSERLALREKLKCRSFKWYLENVYPEM-----RIYNNTLTYGEV 469

  Fly   501 QNVANPVYCLDNMGKSTEEAVGMFSCADNRTHPQPNQFWELSIFRDLRMKGF-------DSVCLD 558
            :|.....||||...:..:.|: ::.|     |...:|....|....|::...       ||.||
Mouse   470 RNSKASGYCLDQGAEDDDRAI-LYPC-----HGMSSQLVRYSAEGLLQLGPLGSTAFLPDSKCL- 527

  Fly   559 VHEGPPNATVWMWSCHSQGGNQFWYYDRQTQRL--------VHGENNKRCLEGFVE-----NGIA 610
            |.:|...... :..|....        |.||||        :...:..||||  ||     |...
Mouse   528 VDDGRGRMPT-LKKCEDVA--------RPTQRLWDFTQSGPIVSRDTGRCLE--VEMSKDANFGL 581

  Fly   611 KVVANSCENGNDRQRW 626
            ::|...|..    |:|
Mouse   582 RLVVQRCSG----QKW 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant4	NP_001137779.1	BcsA	169..>403	CDD:224136	95/239 (40%)
		pp-GalNAc-T	181..480	CDD:133004	123/306 (40%)
		Ricin_B_lectin	496..626	CDD:279046	34/149 (23%)
		RICIN	498..628	CDD:238092	35/149 (23%)
Galnt9	NP_938048.2	pp-GalNAc-T	155..454	CDD:133004	123/306 (40%)
		Ricin_B_lectin	465..593	CDD:279046	34/149 (23%)
		RICIN	467..595	CDD:238092	35/149 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842534
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740