DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant4 and Galnt3

DIOPT Version :9

Sequence 1:	NP_001137779.1	Gene:	Pgant4 / 261610	FlyBaseID:	FBgn0051956	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_056551.2	Gene:	Galnt3 / 14425	MGIID:	894695	Length:	633	Species:	Mus musculus

Alignment Length:	704	Identity:	218/704 - (30%)
Similarity:	339/704 - (48%)	Gaps:	151/704 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAIKKRYVKRLLRK------------VVLLLVVIVTVSLVTTL-------VVERRMKN------- 39
            ||..||.||..:::            :...|||::.:....::       .:||.:||
Mouse     1 MAHLKRLVKLHIKRHYHRKFWKLGAVIFFFLVVLILMQREVSVQYSKEESKMERNLKNKNKMLDF 65

  Fly    40 -----------------AAELTEQLDPNGDP-ITPVFRAANIHPTRKAPRPPFQDRNSVVDIPRS 86
                             .|.:.|.:|....| :...:.||.:.|.  ..||| ||.|:.
Mouse    66 MLEAVNNIKDAMPKMQIGAPIKENIDVRERPCLQGYYTAAELKPV--FDRPP-QDSNAP------ 121

  Fly    87 DKLQGFRLPEPKGERKDWHDYAAMEADRKRSGFGEHGVAVKIEN-PDEKQLEKEHYE-MNGFNGL 149
                                             |..|...||.: ..|:|.|||..| .:.||..
Mouse   122 ---------------------------------GASGKPFKITHLSPEEQKEKERGETKHCFNAF 153

  Fly   150 ISDRISVNRSV-PDLRLEACKTRKY--LAKLPNISVIFIFFNEHFNTLLRSIYSVINRTPPELLK 211
            .|||||::|.: ||.|...|..:|:  ...||..|||.:|.||.::||||:::||:..:|..|||
Mouse   154 ASDRISLHRDLGPDTRPPECIEQKFKRCPPLPTTSVIIVFHNEAWSTLLRTVHSVLYSSPAILLK 218

  Fly   212 QIVLVDDGSEWDVLKQPLDDYVQQHFPHLVTIVRNPERQGLIGARIAGAKVAVGQVMVFFDSHIE 276
            :|:||||.|..|.|.:.|::|::|.  .:|.|||..||:|||.||:.||.||..:.:.|.|:|.|
Mouse   219 EIILVDDASVDDYLHEKLEEYIKQF--SIVKIVRQQERKGLITARLLGAAVATAETLTFLDAHCE 281

  Fly   277 VNYNWLPPLIEPIAINPKISTCPMVDTISHEDFSYFSGNKDGA------RGGFDWKMLY--KQLP 333
            ..|.||.||:..||.|......|.:.:|   |.:.|..||...      ||.|||.:.:  :.||
Mouse   282 CFYGWLEPLLARIAENYTAVVSPDIASI---DLNTFEFNKPSPYGSNHNRGNFDWSLSFGWESLP 343

  Fly   334 VLPED-ALDKSMPYRSPVMMGGLFAINTDFFWDLGGYDDQLDIWGGEQYELSFKIWMCGGMLLDV 397
            ...:. ..|::.|.::|...||||:|:..:|..:|.||::::|||||..|:||::|.|||.|..:
Mouse   344 DHEKQRRKDETYPIKTPTFAGGLFSISKKYFEHIGSYDEEMEIWGGENIEMSFRVWQCGGQLEIM 408

  Fly   398 PCSRVAHIFRGPMKPRGNPRGHNFVAKNHKRVAEVWMDEYKQYVYKRDPKTYDNLDA-------- 454
            |||.|.|:||. ..|...|:|...:|:|..|:|||||||||:..|:|      |.||
Mouse   409 PCSVVGHVFRS-KSPHTFPKGTQVIARNQVRLAEVWMDEYKEIFYRR------NTDAAKIVKQKS 466

  Fly   455 -GDLTRQRGVRERLKCKSFHWFMTEVAPDFLVKFPPVEPPSYAAGIIQNVANPVYCLDNMGKSTE 518
             |||:::..:::||:||:|.|::..:.|:..|  |.:.|  ..:|.|::|..|: ||| :|::.:
Mouse   467 FGDLSKRFEIKKRLQCKNFTWYLNTIYPEAYV--PDLNP--VISGYIKSVGQPL-CLD-VGENNQ 525

  Fly   519 --EAVGMFSCADNRTHP-QPNQFWELSIFRDLRMKGFDSVCLDVHEGPPNATVWMWSCHSQG--- 577
              :.:.:::|     |. ..||::|.|..|::|......:||...:|    .|.:.:|..:|
Mouse   526 GGKPLILYTC-----HGLGGNQYFEYSAQREIRHNIQKELCLHATQG----VVQLKACVYKGHRT 581

  Fly   578 ---GNQFWYYDRQTQRLVHGENNKRCLEGFVENGIAKVVANSCENGNDRQRWEF 628
               |.|.|  :.:..:|::....|.||.   .||....:. .|:..:..|:|.|
Mouse   582 IAPGEQIW--EIRKDQLLYNPLFKMCLS---SNGEHPNLV-PCDATDLLQKWIF 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant4	NP_001137779.1	BcsA	169..>403	CDD:224136	98/244 (40%)
		pp-GalNAc-T	181..480	CDD:133004	128/316 (41%)
		Ricin_B_lectin	496..626	CDD:279046	33/138 (24%)
		RICIN	498..628	CDD:238092	34/138 (25%)
Galnt3	NP_056551.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..145		15/72 (21%)
		WcaA	184..>302	CDD:223539	56/119 (47%)
		Catalytic subdomain A	184..293		53/110 (48%)
		pp-GalNAc-T	188..493	CDD:133004	128/316 (41%)
		Catalytic subdomain B	356..418		29/61 (48%)
		Ricin_B_lectin	506..627	CDD:279046	33/137 (24%)
		RICIN	507..629	CDD:238092	34/138 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810