Protein Alignment Pgant4 and Galnt3

DIOPT Version :10

• Sequence 1: NP_722910.2
• Gene: Pgant4 / 261610
• FlyBaseID: FBgn0051956
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_056551.2
• Gene: Galnt3 / 14425
• MGIID: 894695
• Length: 633
• Species: Mus musculus
• Alignment Length: 704
• Identity: 218/704 - (30%)
• Similarity: 339/704 - (48%)
• Gaps: 151/704 - (21%)

  Fly     1 MAIKKRYVKRLLRK------------VVLLLVVIVTVSLVTTL-------VVERRMKN------- 39
            ||..||.||..:::            :...|||::.:....::       .:||.:||
Mouse     1 MAHLKRLVKLHIKRHYHRKFWKLGAVIFFFLVVLILMQREVSVQYSKEESKMERNLKNKNKMLDF 65

  Fly    40 -----------------AAELTEQLDPNGDP-ITPVFRAANIHPTRKAPRPPFQDRNSVVDIPRS 86
                             .|.:.|.:|....| :...:.||.:.|.  ..||| ||.|:.
Mouse    66 MLEAVNNIKDAMPKMQIGAPIKENIDVRERPCLQGYYTAAELKPV--FDRPP-QDSNAP------ 121

  Fly    87 DKLQGFRLPEPKGERKDWHDYAAMEADRKRSGFGEHGVAVKIEN-PDEKQLEKEHYE-MNGFNGL 149
                                             |..|...||.: ..|:|.|||..| .:.||..
Mouse   122 ---------------------------------GASGKPFKITHLSPEEQKEKERGETKHCFNAF 153

  Fly   150 ISDRISVNRSV-PDLRLEACKTRKY--LAKLPNISVIFIFFNEHFNTLLRSIYSVINRTPPELLK 211
            .|||||::|.: ||.|...|..:|:  ...||..|||.:|.||.::||||:::||:..:|..|||
Mouse   154 ASDRISLHRDLGPDTRPPECIEQKFKRCPPLPTTSVIIVFHNEAWSTLLRTVHSVLYSSPAILLK 218

  Fly   212 QIVLVDDGSEWDVLKQPLDDYVQQHFPHLVTIVRNPERQGLIGARIAGAKVAVGQVMVFFDSHIE 276
            :|:||||.|..|.|.:.|::|::|.  .:|.|||..||:|||.||:.||.||..:.:.|.|:|.|
Mouse   219 EIILVDDASVDDYLHEKLEEYIKQF--SIVKIVRQQERKGLITARLLGAAVATAETLTFLDAHCE 281

  Fly   277 VNYNWLPPLIEPIAINPKISTCPMVDTISHEDFSYFSGNKDGA------RGGFDWKMLY--KQLP 333
            ..|.||.||:..||.|......|.:.:|   |.:.|..||...      ||.|||.:.:  :.||
Mouse   282 CFYGWLEPLLARIAENYTAVVSPDIASI---DLNTFEFNKPSPYGSNHNRGNFDWSLSFGWESLP 343

  Fly   334 VLPED-ALDKSMPYRSPVMMGGLFAINTDFFWDLGGYDDQLDIWGGEQYELSFKIWMCGGMLLDV 397
            ...:. ..|::.|.::|...||||:|:..:|..:|.||::::|||||..|:||::|.|||.|..:
Mouse   344 DHEKQRRKDETYPIKTPTFAGGLFSISKKYFEHIGSYDEEMEIWGGENIEMSFRVWQCGGQLEIM 408

  Fly   398 PCSRVAHIFRGPMKPRGNPRGHNFVAKNHKRVAEVWMDEYKQYVYKRDPKTYDNLDA-------- 454
            |||.|.|:||. ..|...|:|...:|:|..|:|||||||||:..|:|      |.||
Mouse   409 PCSVVGHVFRS-KSPHTFPKGTQVIARNQVRLAEVWMDEYKEIFYRR------NTDAAKIVKQKS 466

  Fly   455 -GDLTRQRGVRERLKCKSFHWFMTEVAPDFLVKFPPVEPPSYAAGIIQNVANPVYCLDNMGKSTE 518
             |||:::..:::||:||:|.|::..:.|:..|  |.:.|  ..:|.|::|..|: ||| :|::.:
Mouse   467 FGDLSKRFEIKKRLQCKNFTWYLNTIYPEAYV--PDLNP--VISGYIKSVGQPL-CLD-VGENNQ 525

  Fly   519 --EAVGMFSCADNRTHP-QPNQFWELSIFRDLRMKGFDSVCLDVHEGPPNATVWMWSCHSQG--- 577
              :.:.:::|     |. ..||::|.|..|::|......:||...:|    .|.:.:|..:|
Mouse   526 GGKPLILYTC-----HGLGGNQYFEYSAQREIRHNIQKELCLHATQG----VVQLKACVYKGHRT 581

  Fly   578 ---GNQFWYYDRQTQRLVHGENNKRCLEGFVENGIAKVVANSCENGNDRQRWEF 628
               |.|.|  :.:..:|::....|.||.   .||....:. .|:..:..|:|.|
Mouse   582 IAPGEQIW--EIRKDQLLYNPLFKMCLS---SNGEHPNLV-PCDATDLLQKWIF 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant4	NP_722910.2	pp-GalNAc-T	181..480	CDD:133004	128/316 (41%)
		beta-trefoil_Ricin_Pgant9-like	493..629	CDD:467340	35/145 (24%)
Galnt3	NP_056551.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..145		15/72 (21%)
		Catalytic subdomain A	184..293		53/110 (48%)
		pp-GalNAc-T	188..493	CDD:133004	128/316 (41%)
		Catalytic subdomain B	356..418		29/61 (48%)
		beta-trefoil_Ricin-like	502..630	CDD:483949	36/147 (24%)