Protein Alignment Pgant4 and Galnt1

DIOPT Version :10

• Sequence 1: NP_722910.2
• Gene: Pgant4 / 261610
• FlyBaseID: FBgn0051956
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_038842.3
• Gene: Galnt1 / 14423
• MGIID: 894693
• Length: 559
• Species: Mus musculus
• Alignment Length: 522
• Identity: 210/522 - (40%)
• Similarity: 309/522 - (59%)
• Gaps: 35/522 - (6%)

  Fly   114 RKRSGFGEHGVAVKIENPDEKQLEKEHYEMNGFNGLISDRISVNRSVPDLRLEACKTRKYLAKLP 178
            :...|.||.|..|.|...|:::: ||.:::|.||.:.|:.|::|||:||:|||.|||:.|...||
Mouse    53 KPHEGPGEMGKPVVIPKEDQEKM-KEMFKINQFNLMASEMIALNRSLPDVRLEGCKTKVYPDNLP 116

  Fly   179 NISVIFIFFNEHFNTLLRSIYSVINRTPPELLKQIVLVDDGSEWDVLKQPLDDYVQQ-HFPHLVT 242
            ..||:.:|.||.::||||:::|||||:|..::::||||||.||.|.||:||:.||:: ..|  |.
Mouse   117 TTSVVIVFHNEAWSTLLRTVHSVINRSPRHMIEEIVLVDDASERDFLKRPLESYVKKLKVP--VH 179

  Fly   243 IVRNPERQGLIGARIAGAKVAVGQVMVFFDSHIEVNYNWLPPLIEPIAINPKISTCPMVDTISHE 307
            ::|..:|.|||.||:.||.|:.|||:.|.|:|.|....||.||:..|..:.:...||::|.||.:
Mouse   180 VIRMEQRSGLIRARLKGAAVSRGQVITFLDAHCECTAGWLEPLLARIKHDRRTVVCPIIDVISDD 244

  Fly   308 DFSYFSGNKDGARGGFDWKMLYKQLPVLPEDAL-----DKSMPYRSPVMMGGLFAINTDFFWDLG 367
            .|.|.:|: |...|||:||:.::..|| |:..:     |:::|.|:|.|.||||:|:.|:|.::|
Mouse   245 TFEYMAGS-DMTYGGFNWKLNFRWYPV-PQREMDRRKGDRTLPVRTPTMAGGLFSIDRDYFQEIG 307

  Fly   368 GYDDQLDIWGGEQYELSFKIWMCGGMLLDVPCSRVAHIFRGPMKPRGNPRG-HNFVAKNHKRVAE 431
            .||..:||||||..|:||:||.|||.|..|.||.|.|:|| ...|...|.| ...:.||::|:||
Mouse   308 TYDAGMDIWGGENLEISFRIWQCGGTLEIVTCSHVGHVFR-KATPYTFPGGTGQIINKNNRRLAE 371

  Fly   432 VWMDEYKQYVYKRDPKTYDNLDAGDLTRQRGVRERLKCKSFHWFMTEVAPDFLVKFPPVEPPSY- 495
            |||||:|.:.|...|.. ..:|.||::.:.|:|.:|:||.|.|::..:.||..:      |..|
Mouse   372 VWMDEFKNFFYIISPGV-TKVDYGDISSRLGLRRKLQCKPFSWYLENIYPDSQI------PRHYF 429

  Fly   496 AAGIIQNVANPVYCLDNMGKSTEEAVGMFSCADNRTHPQ-PNQFWELSIFRDLRMKGFDSVCLDV 559
            :.|.|:||... .|||||.:...|.||:|:|     |.. .||.:..:..:::|.   |.:||||
Mouse   430 SLGEIRNVETN-QCLDNMARKENEKVGIFNC-----HGMGGNQVFSYTANKEIRT---DDLCLDV 485

  Fly   560 HEGPPNATVWMWSCHSQGGNQFWYYDRQTQRLVHGENNKRCLEGFVENGIAKVVANSCENGNDRQ 624
            .:  .|..|.|..||...|||.|.||.....|.| .|:.:||:...|..........| .|:..|
Mouse   486 SK--LNGPVTMLKCHHLKGNQLWEYDPVKLTLQH-VNSNQCLDKATEEDSQVPSIRDC-TGSRSQ 546

  Fly   625 RW 626
            :|
Mouse   547 QW 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant4	NP_722910.2	pp-GalNAc-T	181..480	CDD:133004	134/305 (44%)
		beta-trefoil_Ricin_Pgant9-like	493..629	CDD:467340	45/136 (33%)
Galnt1	NP_038842.3	Catalytic subdomain A. /evidence=ECO:0000305|PubMed:10037781	115..225		55/111 (50%)
		pp-GalNAc-T	119..419	CDD:133004	134/305 (44%)
		Catalytic subdomain B. /evidence=ECO:0000305|PubMed:10037781	285..347		34/61 (56%)
		beta-trefoil_Ricin_GALNT1	426..552	CDD:467344	45/136 (33%)