DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant4 and GALNT15

DIOPT Version :9

Sequence 1:	NP_001137779.1	Gene:	Pgant4 / 261610	FlyBaseID:	FBgn0051956	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_473451.3	Gene:	GALNT15 / 117248	HGNCID:	21531	Length:	639	Species:	Homo sapiens

Alignment Length:	683	Identity:	198/683 - (28%)
Similarity:	329/683 - (48%)	Gaps:	100/683 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAIKKRYVKRLLRKVVLLLVVIV--TVSLVTTL----------VVERRMKNAAELTEQLD----- 48
            |.::|||..|..|...|||::::  .:.:|..|          |..:..|::.|...:||
Human     1 MLLRKRYRHRPCRLQFLLLLLMLGCVLMMVAMLHPPHHTLHQTVTAQASKHSPEARYRLDFGESQ 65

  Fly    49 -------PNGDPITPVFRAANIHPTRKAPRPPF----QDRNSV-VDIP--RSDKLQGFR------ 93
                   ..|:..:|:           ...|||    :|:..| |.:|  |.::.||.|
Human    66 DWVLEAEDEGEEYSPL-----------EGLPPFISLREDQLLVAVALPQARRNQSQGRRGGSYRL 119

  Fly    94 LPEPKGERKDWHDYAAMEADRKRSGFGEHGVAVKIENPDEKQLEKEHYEMNGFNGLISDRISVNR 158
            :.:|:.:.|        ||.::..|..|.|     |..:|::|.....:..|....:|.||.:.|
Human   120 IKQPRRQDK--------EAPKRDWGADEDG-----EVSEEEELTPFSLDPRGLQEALSARIPLQR 171

  Fly   159 SVPDLRLEACKTRKYLAKLPNISVIFIFFNEHFNTLLRSIYSVINRTPPELLKQIVLVDDGSEWD 223
            ::|::|...|..:.....||..|||..|.:|.::||||:::|:::..|...||:|:||||.|:..
Human   172 ALPEVRHPLCLQQHPQDSLPTASVILCFHDEAWSTLLRTVHSILDTVPRAFLKEIILVDDLSQQG 236

  Fly   224 VLKQPLDDYVQQHFPHLVTIVRNPERQGLIGARIAGAKVAVGQVMVFFDSHIEVNYNWLPPLIEP 288
            .||..|.:||.:  ...|.::|:.:|.|.|.||:.||..|.|.|:||.|:|.|.:..||.||:..
Human   237 QLKSALSEYVAR--LEGVKLLRSNKRLGAIRARMLGATRATGDVLVFMDAHCECHPGWLEPLLSR 299

  Fly   289 IAINPKISTCPMVDTISHEDFSYFSGNKDGARGGFDWKMLYKQLPVLPE---DALDKSM-PYRSP 349
            ||.:......|::|.|..:.|.|:. :||..||..|||:.:...| |||   .||...: |.|||
Human   300 IAGDRSRVVSPVIDVIDWKTFQYYP-SKDLQRGVLDWKLDFHWEP-LPEHVRKALQSPISPIRSP 362

  Fly   350 VMMGGLFAINTDFFWDLGGYDDQLDIWGGEQYELSFKIWMCGGMLLDVPCSRVAHIFRGPMKPRG 414
            |:.|.:.|::..:|.:.|.||..:.:.|||..|||||.|:|||.:..:|||||.||::.  :...
Human   363 VVPGEVVAMDRHYFQNTGAYDSLMSLRGGENLELSFKAWLCGGSVEILPCSRVGHIYQN--QDSH 425

  Fly   415 NPRGHNFVAKNHKRVAEVWMDEYKQYVYKRDPKTY--DNLDAGDLTRQRGVRERLKCKSFHWFMT 477
            :|.......:|..|:||.|:..:|:..||..|:.:  ...:..|...:..::.||.|::||||:.
Human   426 SPLDQEATLRNRVRIAETWLGSFKETFYKHSPEAFSLSKAEKPDCMERLQLQRRLGCRTFHWFLA 490

  Fly   478 EVAPDFLVKFPPVEP-PSYAAGIIQNVANPVYCLDNMGKSTEEAVG----MFSCADNRTHPQPNQ 537
            .|.|:..    |.|| ||: :|.:.|....: |.|...:.  :.:|    :..|:|:|    ..|
Human   491 NVYPELY----PSEPRPSF-SGKLHNTGLGL-CADCQAEG--DILGCPMVLAPCSDSR----QQQ 543

  Fly   538 FWELSIFRDLRMKGFDSVCLDVHEGPPNATVWMWSCHSQG---GNQFWYYDRQTQRLVHGENNKR 599
            :.:.:..:::.......:|..|.:    ..|.:.:|..:|   ..|.|.: ::...:||..:.|
Human   544 YLQHTSRKEIHFGSPQHLCFAVRQ----EQVILQNCTEEGLAIHQQHWDF-QENGMIVHILSGK- 602

  Fly   600 CLEGFVENGIAKVVANSCENGNDRQRWEFGFVN 632
            |:|..|:.....:....|: |..||:|.|..:|
Human   603 CMEAVVQENNKDLYLRPCD-GKARQQWRFDQIN 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant4	NP_001137779.1	BcsA	169..>403	CDD:224136	94/237 (40%)
		pp-GalNAc-T	181..480	CDD:133004	113/304 (37%)
		Ricin_B_lectin	496..626	CDD:279046	26/136 (19%)
		RICIN	498..628	CDD:238092	27/136 (20%)
GALNT15	NP_473451.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	106..155		13/61 (21%)
		Catalytic subdomain A	190..299		47/110 (43%)
		Glyco_tranf_2_3	191..447	CDD:290369	102/261 (39%)
		pp-GalNAc-T	194..493	CDD:133004	113/304 (37%)
		Catalytic subdomain B	358..420		30/61 (49%)
		Ricin_B_lectin	505..628	CDD:279046	26/137 (19%)
		RICIN	507..630	CDD:238092	27/136 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152479
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740