Protein Alignment Pgant4 and Galnt2

DIOPT Version :10

• Sequence 1: NP_722910.2
• Gene: Pgant4 / 261610
• FlyBaseID: FBgn0051956
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_644678.2
• Gene: Galnt2 / 108148
• MGIID: 894694
• Length: 570
• Species: Mus musculus
• Alignment Length: 569
• Identity: 183/569 - (32%)
• Similarity: 286/569 - (50%)
• Gaps: 63/569 - (11%)

  Fly    76 DRNSVVDIPRSD--------KLQGFR-LPEPKGERKDWHDYAAMEADRKRSGFGEHGVAVKIENP 131
            |.|.:..|.:.|        |.||.. ||..|....|::..|.:.....|||
Mouse    43 DWNDIDSIKKKDLHHSRGDEKAQGVETLPPGKVRWPDFNQEAYVGGTMVRSG------------- 94

  Fly   132 DEKQLEKEHYEMNGFNGLISDRISVNRSVPDLRLEACKTRKYLAKLPNISVIFIFFNEHFNTLLR 196
                  ::.|..|.||.:.||::.::|.:||.|.:.|:.:::...||..||:..|.||..:.|||
Mouse    95 ------QDPYARNKFNQVESDKLHMDRGIPDTRHDQCQRKQWRVDLPATSVVITFHNEARSALLR 153

  Fly   197 SIYSVINRTPPELLKQIVLVDDGSEWDVLKQPLDDYVQQHFPHLVTIVRNPERQGLIGARIAGAK 261
            ::.||:.|:||.|:|:|:||||.|     ..|.|..:.... ..|.::||..|:||:.:|:.||.
Mouse   154 TVVSVLKRSPPHLIKEIILVDDYS-----NDPEDGALLGKI-EKVRVLRNDRREGLMRSRVRGAD 212

  Fly   262 VAVGQVMVFFDSHIEVNYNWLPPLIEPIAINPKISTCPMVDTISHEDFSYFSGNKDGARGGFDWK 326
            .|..:|:.|.|||.|.|..||.||:|.:|.:......|::|.|:.::|.|...:.| .:|||||.
Mouse   213 AAQAKVLTFLDSHCECNERWLEPLLERVAEDRTRVVSPIIDVINMDNFQYVGASAD-LKGGFDWN 276

  Fly   327 MLYKQLPVLPEDALDKS----MPYRSPVMMGGLFAINTDFFWDLGGYDDQLDIWGGEQYELSFKI 387
            :::|...:.||....:.    .|.::|::.||||.::..:|.:||.||..:|:||||..|:||::
Mouse   277 LVFKWDYMTPEQRRSRQGNPVAPIKTPMIAGGLFVMDKLYFEELGKYDMMMDVWGGENLEISFRV 341

  Fly   388 WMCGGMLLDVPCSRVAHIFRGPMKPRGNPRGHNFV-AKNHKRVAEVWMDEYKQYVYKRDPKTYDN 451
            |.|||.|..:|||||.|:|| ...|...|.|...| |:|.:|.|||||||||.:.|...|.. .|
Mouse   342 WQCGGSLEIIPCSRVGHVFR-KQHPYTFPGGSGTVFARNTRRAAEVWMDEYKHFYYAAVPSA-RN 404

  Fly   452 LDAGDLTRQRGVRERLKCKSFHWFMTEVAPDFLVKFPPVEPPSYAAGIIQNVANPVYCLDNMGKS 516
            :..|::..:..:|::|.||.|.|::..|.|:..|.    :....|.|.:|...|   |||.:|..
Mouse   405 VPYGNIQSRLELRKKLGCKPFKWYLDNVYPELRVP----DHQDIAFGALQQGTN---CLDTLGHF 462

  Fly   517 TEEAVGMFSCADNRTHPQPNQFWELSIFRDLRMKGFDSVCLDVHEGPPNATVWMWSCHSQGGNQF 581
            .:..||::.|    .:...||.|.|:  ::..:|..| :||.|.:..|.:.:.:..|......|.
Mouse   463 ADGVVGIYEC----HNAGGNQEWALT--KEKSVKHMD-LCLTVVDRSPGSLIRLQGCRENDSRQK 520

  Fly   582 WYYDRQTQRLVHGENNKRCLEGFV--ENGIAKVVANSCENGNDRQRWEF 628
            |.......:|.|..:| .||:...  ..|::..|.....:    |:|:|
Mouse   521 WEQIEGNSKLRHVGSN-LCLDSRTAKSGGLSVEVCGPALS----QQWKF 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant4	NP_722910.2	pp-GalNAc-T	181..480	CDD:133004	118/303 (39%)
		beta-trefoil_Ricin_Pgant9-like	493..629	CDD:467340	34/138 (25%)
Galnt2	NP_644678.2	Catalytic subdomain A	134..239		46/110 (42%)
		pp-GalNAc-T	138..433	CDD:133004	118/303 (39%)
		Catalytic subdomain B	299..361		30/61 (49%)
		beta-trefoil_Ricin_GALNT2	445..564	CDD:467312	33/133 (25%)