Protein Alignment Pgant4 and POC1B-GALNT4

DIOPT Version :10

• Sequence 1: NP_722910.2
• Gene: Pgant4 / 261610
• FlyBaseID: FBgn0051956
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_001186710.1
• Gene: POC1B-GALNT4 / 100528030
• HGNCID: 42957
• Length: 575
• Species: Homo sapiens
• Alignment Length: 621
• Identity: 209/621 - (33%)
• Similarity: 314/621 - (50%)
• Gaps: 80/621 - (12%)

  Fly    32 VVERRMK--NAAELTEQLDPNGDPITPVFRAANIHPTRKAPRPPFQDRNSVVDIPRSDKLQGFRL 94
            |:||..|  .||..:..|.|||..:                           ...|:.:|...||
Human     9 VLERYFKGHKAAITSLDLSPNGKQL---------------------------GAGRARELGSRRL 46

  Fly    95 PEPKGERKDWHD--YAAMEADRKRSGFGEHGVAVKIE-NPDEKQLEKEHYEMNGFNGLISDRISV 156
            .:.:...:|...  |....||.:  ..||.|.|.|:: |.||.:.::|..|....|..:|||||:
Human    47 SDLQKNTEDLSRPLYKKPPADSR--ALGEWGKASKLQLNEDELKQQEELIERYAINIYLSDRISL 109

  Fly   157 NRSVPDLRLEACKTRKY-LAKLPNISVIFIFFNEHFNTLLRSIYSVINRTPPELLKQIVLVDDGS 220
            :|.:.|.|:..||::|: ...||..|||..|:||.::||||:|:||:..:|..|||:|:||||.|
Human   110 HRHIEDKRMYECKSQKFNYRTLPTTSVIIAFYNEAWSTLLRTIHSVLETSPAVLLKEIILVDDLS 174

  Fly   221 EWDVLKQPLDDYVQQHFPHLVTIVRNPERQGLIGARIAGAKVAVGQVMVFFDSHIEVNYNWLPPL 285
            :...||..|:.|:..  ...|.::|..:|:||:.||:.||..|.|.|:.|.|.|.|.|..||.||
Human   175 DRVYLKTQLETYISN--LDRVRLIRTNKREGLVRARLIGATFATGDVLTFLDCHCECNSGWLEPL 237

  Fly   286 IEPIAINPKISTCPMVDTISHEDFSYFSGNKDGARGGFDWKMLYKQLPVLPEDALDKSM----PY 346
            :|.|..:.....||::|||....|.::....:...|||||::.: |...:|:...|:.:    |.
Human   238 LERIGRDETAVVCPVIDTIDWNTFEFYMQIGEPMIGGFDWRLTF-QWHSVPKQERDRRISRIDPI 301

  Fly   347 RSPVMMGGLFAINTDFFWDLGGYDDQLDIWGGEQYELSFKIWMCGGMLLDVPCSRVAHIFRGPMK 411
            |||.|.|||||::..:|..||.||..:::||||..||||::|.|||.|...|||.|.|:|  |.:
Human   302 RSPTMAGGLFAVSKKYFQYLGTYDTGMEVWGGENLELSFRVWQCGGKLEIHPCSHVGHVF--PKR 364

  Fly   412 -PRGNPRGHNFVAKNHKRVAEVWMDEYKQYVYKRDP----KTYDNLDAGDLTRQRGVRERLKCKS 471
             |...|   ||: :|..|.|||||||||::.|.|:|    :.|     ||::.::.:||||:|||
Human   365 APYARP---NFL-QNTARAAEVWMDEYKEHFYNRNPPARKEAY-----GDISERKLLRERLRCKS 420

  Fly   472 FHWFMTEVAPDFLVKFPPVEPPSYAAGIIQNVANPVYCLDNM---GKSTEEAVGMFSCADNRTHP 533
            |.|::..|.|:..|   |.:.|.: .|.|::......|||..   ...|...:.:|.|     |.
Human   421 FDWYLKNVFPNLHV---PEDRPGW-HGAIRSRGISSECLDYNSPDNNPTGANLSLFGC-----HG 476

  Fly   534 Q-PNQFWELSIFRDLRMKGFDSVCLDVHEGPPNATVWMWSCHSQG----GNQFWYYDRQTQRLVH 593
            | .|||:|.:..:::|......:|.:|.|  ....|.|.:|...|    .|..|:: ::...:.|
Human   477 QGGNQFFEYTSNKEIRFNSVTELCAEVPE--QKNYVGMQNCPKDGFPVPANIIWHF-KEDGTIFH 538

  Fly   594 GENNKRCLEGF-VENGIAKVVANSCENGNDRQRWEF 628
             .::..||..: ...|...|...:|:..:..|.|.|
Human   539 -PHSGLCLSAYRTPEGRPDVQMRTCDALDKNQIWSF 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant4	NP_722910.2	pp-GalNAc-T	181..480	CDD:133004	129/307 (42%)
		beta-trefoil_Ricin_Pgant9-like	493..629	CDD:467340	34/145 (23%)
POC1B-GALNT4	NP_001186710.1	pp-GalNAc-T	135..429	CDD:133004	129/307 (42%)
		beta-trefoil_Ricin_GALNT4	439..574	CDD:467347	34/145 (23%)