DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant4 and galnt3

DIOPT Version :9

Sequence 1:	NP_001137779.1	Gene:	Pgant4 / 261610	FlyBaseID:	FBgn0051956	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	XP_021334717.1	Gene:	galnt3 / 100331984	ZFINID:	ZDB-GENE-120313-1	Length:	625	Species:	Danio rerio

Alignment Length:	668	Identity:	225/668 - (33%)
Similarity:	338/668 - (50%)	Gaps:	92/668 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 YVKRLL-RKVVLLLVVIVTVSLVTTLVVERRMKNAAELTEQLDPNGDP----------------- 53
            :::||| |::..|.:.||.:..||.|.:.:|     |:..| .|..:|
Zfish     3 FIRRLLRRRLHPLKLAIVALVFVTFLFLMQR-----EVVSQ-SPQDEPWLRGIVEKRDGVLGMVM 61

  Fly    54 -ITPVFRAANIHPTRKAPRPPFQDRNSVVDIPRSDKLQGFRLP---EPKGERKDWHDYAAMEADR 114
             ....||.|......|||....:.:.|      |..|.|:..|   :|..||          ..:
Zfish    62 GAVNNFRDAMPKMQIKAPVRQQESQGS------SACLSGYYTPAELKPVLER----------PPQ 110

  Fly   115 KRSGFGEHGVAVKIEN-PDEKQLEKEH-YEMNGFNGLISDRISVNRSV-PDLRLEAC--KTRKYL 174
            ..|..|..|.|...:| ...:|.|||. .|.:.||...|||||::|.: ||.|...|  :|.:..
Zfish   111 NPSAPGASGKAFHTDNLSSSEQKEKERGEEKHCFNLYASDRISLSRDLGPDTRPPECIEQTFRRC 175

  Fly   175 AKLPNISVIFIFFNEHFNTLLRSIYSVINRTPPELLKQIVLVDDGSEWDVLKQPLDDYVQQHFPH 239
            ..||..|||.:|.||.::||||::|||::.:|...||:|:||||.|..:.||..||::::|  .|
Zfish   176 PPLPTTSVIIVFHNEAWSTLLRTVYSVLHTSPALFLKEIILVDDASVDEHLKDKLDEFLKQ--LH 238

  Fly   240 LVTIVRNPERQGLIGARIAGAKVAVGQVMVFFDSHIEVNYNWLPPLIEPIAINPKISTCPMVDTI 304
            :|.:||..||:|||.||:.||.||.|..:.|.|:|.|..:.||.||:..||.|......|.:.||
Zfish   239 IVRVVRQHERKGLITARLLGASVATGDTLTFLDAHCECFHGWLEPLLARIAENSSAVVSPDITTI 303

  Fly   305 SHEDFSYFSGNKDGA---RGGFDWKMLYKQLPVLPED----ALDKSMPYRSPVMMGGLFAINTDF 362
            ....|.:...:..|.   ||.|||.:.: ....||:.    ..|::.|.::|...||||:|:.|:
Zfish   304 DLNTFEFMKPSPYGQHHNRGNFDWGLSF-GWETLPDHERRRRKDETYPIKTPTFAGGLFSISRDY 367

  Fly   363 FWDLGGYDDQLDIWGGEQYELSFKIWMCGGMLLDVPCSRVAHIFRGPMKPRGNPRGHNFVAKNHK 427
            |:.:|.||::::|||||..|:||::|.|||.|..:|||.|.|:|| ...|...|:|...:|:|..
Zfish   368 FYHIGSYDEEMEIWGGENIEMSFRVWQCGGQLEIIPCSVVGHVFR-TKSPHTFPKGTQVIARNQV 431

  Fly   428 RVAEVWMDEYKQYVYKRDPKTYD---NLDAGDLTRQRGVRERLKCKSFHWFMTEVAPDFLVKFPP 489
            |:||||||:||:..|:|:.:...   ....||::|:..:||||:||||.|::..|.|:  |..|.
Zfish   432 RLAEVWMDDYKEIFYRRNQQAAQIAKEHSFGDVSRRVDLRERLQCKSFSWYLKNVYPE--VFMPD 494

  Fly   490 VEPPSYAAGIIQNVANPVYCLDNMGKSTE--EAVGMFSCADNRTHPQ-PNQFWELSIFRDLRMKG 551
            :.|..:  |.|:|:.... ||| :|:|.|  :.:.|:.|     |.. .||::|.|...::|...
Zfish   495 LNPLQF--GAIRNMGKEA-CLD-VGESNEGGKPLIMYPC-----HGMGGNQYFEYSTHHEIRHNI 550

  Fly   552 FDSVCLDVHEGPPNATVWMWSCHSQGGN------QFWYYDRQTQRLVHGENNKRCLEGFVENGIA 610
            ...:|||   |...|.|.:..|..:|.|      |.|  :.:..:|.:.:.:|:||....||  .
Zfish   551 QKELCLD---GTDGAMVRLEECQYKGHNTITSPQQKW--ELREDQLFYNKASKQCLSARPEN--P 608

  Fly   611 KVVANSCENGNDRQRWEF 628
            .:|  .|...:..|.|.|
Zfish   609 SLV--PCNPDDKYQLWLF 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant4	NP_001137779.1	BcsA	169..>403	CDD:224136	98/240 (41%)
		pp-GalNAc-T	181..480	CDD:133004	127/308 (41%)
		Ricin_B_lectin	496..626	CDD:279046	37/138 (27%)
		RICIN	498..628	CDD:238092	38/138 (28%)
galnt3	XP_021334717.1	pp-GalNAc-T	182..487	CDD:133004	127/308 (41%)
galnt3	XP_021334717.1	Ricin_B_lectin	500..622	CDD:306998	37/139 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910