DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IFT172 and Oseg2

DIOPT Version :9

Sequence 1:	NP_056477.1	Gene:	IFT172 / 26160	HGNCID:	30391	Length:	1749	Species:	Homo sapiens
Sequence 2:	NP_647700.2	Gene:	Oseg2 / 38282	FlyBaseID:	FBgn0035317	Length:	1754	Species:	Drosophila melanogaster

Alignment Length:	1768	Identity:	833/1768 - (47%)
Similarity:	1200/1768 - (67%)	Gaps:	50/1768 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MHLKHLRTLLSPQDGAAKVTCMAWSQNNAKFAVCTVDRVVLLYDEHGERRDKFSTKPADMKYGRK 65
            |.||:|||||..|:...::..:|||.|..:.|:.|.||.:||||:.||||||||||||:...|:.
  Fly     1 MQLKYLRTLLEGQEQIQRIAGLAWSPNQQRLAIATADRHILLYDDAGERRDKFSTKPANPANGKN 65

Human    66 SYMVKGMAFSPDSTKIAIGQTDNIIYVYKIGEDWGDKKVICNKFIQTSAVTCLQWPAEYIIVFGL 130
            ||:::|:||||||||:|:||:|:|:||||:||.|.|||||||||.|.||||.|.|.....|:.||
  Fly    66 SYVIRGLAFSPDSTKLAVGQSDSIVYVYKLGESWNDKKVICNKFPQASAVTALIWLTSGSIIAGL 130

Human   131 AEGKVRLANTKTNKSSTIYGTESYVVSLTTNCSGKGILSGHADGTIVRYFFDDEGSGESQGKLVN 195
            .:||||..::|:|||.::||.:|..:||..|..|.|.||||.||||:|||..||.: |..|::|.
  Fly   131 EDGKVRALHSKSNKSQSLYGGDSICISLAANTKGTGFLSGHNDGTIIRYFMTDEAT-EPLGRVVQ 194

Human   196 HPCPPYALAWATNSIVAAGCDRKIVAYGKEGHMLQTFDYSRDPQEREFTTAVSSPGGQSVVLGSY 260
            ||.||:||||......|.|||::||.|...|..|:|||:||...|||||.|..||.||:|..||:
  Fly   195 HPVPPFALAWPQGGFCAGGCDQRIVFYDSMGRQLRTFDHSRTEGEREFTVAACSPNGQAVAFGSF 259

Human   261 DRLRVFNWIPRRSIWEEAKPKEITNLYTITALAWKRDGSRLCVGTLCGGVEQFDCCLRRSIYKNK 325
            ||:|:|.|.||:..|.|:..||:..|||:::|.|:|||:||.:|::.|.|..|:..|||:::::|
  Fly   260 DRIRIFAWSPRQGAWSESATKEVACLYTLSSLLWRRDGARLALGSVSGAVLLFESVLRRTVWQDK 324

Human   326 FELTYVGPSQVIVKNLSSGTR-VVLKSHYGYEVEEVKILGKERYLVAHTSETLLLGDLNTNRLSE 389
            |||.:|.|||::|::|:..:: :.::|..|.|:::|:|:|::.||||.|.|:|:|.||..|..||
  Fly   325 FELIFVAPSQLLVRSLTEPSQALTIESQLGLEIDDVRIMGRDNYLVARTEESLILCDLTRNLSSE 389

Human   390 IAWQGSGGNEKYFFENENVCMIFNAGELTLVEYGNNDTLGSVRTEFMNPHLISVRINERCQRGTE 454
            :.|..||.:|:::|||..||:|||.|||:|||||.|..||||||||:|||:||||:|||  ...:
  Fly   390 VPWTASGHHERFYFENPTVCLIFNVGELSLVEYGENSILGSVRTEFVNPHVISVRLNER--GNAK 452

Human   455 DNKKLAYLIDIKTIAIVDLIGGYNIGTVSHESRVDWLELNETGHKLLFRDRKLRLHLYDIESCSK 519
            :|||||:|:|.|||.:||||.....|.:|||:::|||||:||.|||||||:||||.|.|..:..|
  Fly   453 ENKKLAFLLDAKTICVVDLISRMTSGQISHETKIDWLELSETAHKLLFRDKKLRLILVDNYTGKK 517

Human   520 TMILNFCSYMQWVPGSDVLVAQNRNSLCVWYNIEAPERVTMFTIRGDVIGLERGGGKTEVMVMEG 584
            ..:|:..|::||||.|||:|||:.::|.:||||:.||.|||.::||:.|.:.|..|:|.|...:|
  Fly   518 QTLLSNISFVQWVPQSDVVVAQSNSNLAIWYNIDLPEHVTMQSVRGEAIEVLRENGRTVVRSQDG 582

Human   585 VTTVAYTLDEGLIEFGTAIDDGNYIRATAFLETLEMTPETEAMWKTLSKLALEARQLHIAERCFS 649
            .:...|.|||||:|||||::|.::.||..|||:|...|..:|||..|:.:|||...|.:|:||::
  Fly   583 PSEHNYQLDEGLVEFGTAVNDSDFGRAVHFLESLGDKPAAKAMWHNLALIALEDGNLRVAQRCYA 647

Human   650 ALGQVAKARFLHETNEIADQVSREYGGEGTDFYQVRARLAMLEKNYKLAEMIFLEQNAVEEAMGM 714
            |||.|:||.:|....:.||:.....|..|....:|||:||:|..:.:.||.|:|||..:|.|:.|
  Fly   648 ALGNVSKAYYLAGMIQQADEFEESSGSPGILCPEVRAKLALLGSDLRTAERIYLEQGDIESALKM 712

Human   715 YQELHRWDECIAVAEAKGHPALEKLRRSYYQWLMDTQQEERAGELQESQGDGLAAISLYLKAGLP 779
            ||:|..|||.:|:||.:|:..:.:|::.:..:|:.::|:|:||::.|.|||...|:|||:||..|
  Fly   713 YQQLGMWDEAVALAERRGYNRIAELKQQHMDYLLSSEQQEKAGQVLEEQGDLQQAMSLYMKANKP 777

Human   780 AKAARLVLTREELLANTELVEHITAALIKGELYERAGDLFEKIHNPQKALECYRKGNAFMKAVEL 844
            |:||||.|....:|.:.:::..:|..|::.||||.|||:..::..|:.||..||||.|:.:|:|:
  Fly   778 ARAARLALKTPHILQDEQVMLQVTEGLVRSELYELAGDIAHRLSRPEAALALYRKGGAYARALEI 842

Human   845 ARLAFPVEVVKLEEAWGDHLVQQKQLDAAINHYIEARCSIKAIEAALGARQWKKAIYILDLQDRN 909
            .|:..|.||..|||.|||.||.:|||||:|||||||..:.||:|||:||:||:||:.|..:.|..
  Fly   843 GRVVAPQEVTALEEEWGDWLVSRKQLDASINHYIEAGATQKALEAAVGAKQWRKAVQIAKVLDEP 907

Human   910 TASKYYPL-VAQHYASLQEYEIAEELYTKGDRTKDAIDMYTQAGRWEQAHKLAMKCMRPEDVSVL 973
            ...:.|.: :|:|.|...:.:.||::..:.:..||||::..:.|:||:|:.:..|.::.|.|..|
  Fly   908 ELIQRYAVDLAKHLAFAGDLDGAEDMLVRANLHKDAIELLNRHGKWERAYLIGEKHLKAEQVREL 972

Human   974 YITQAQEMEKQGKYREAERLYVTVQEPDLAITMYKKHKLYDDMIRLVGKHHPDLLSDTHLHLGKE 1038
            ::..|..:|:|||:|:||::.:.|.||||||.|||:.:|||.|||||.::|.|||..|||||.::
  Fly   973 FVQLAGTLEEQGKFRDAEKVLIAVNEPDLAIAMYKRRELYDSMIRLVERYHKDLLDSTHLHLARQ 1037

Human  1039 LEAEGRLQEAEYHYLEAQEWKATVNMYRASGLWEEAYRVARTQGGANAHKHVAYLWAKSLGGEAA 1103
            ||:.|:|:.||.|::.:.:||:.|:||.:||.||:.||||:.:|...|.:.|||:||||:..|.|
  Fly  1038 LESRGKLKNAEMHFVASGDWKSAVHMYCSSGRWEDGYRVAKLKGTEGASQQVAYMWAKSMPTEGA 1102

Human  1104 VRLLNKLGLLEAAVDHAADNCSFEFAFELSRLALKHKTPEVHLKYAMFLEDEGKFEEAEAEFIRA 1168
            ||||:|||||:.||..|.|:..||||.||.:.|.| .|.|||||.||.||||||||.|||||::|
  Fly  1103 VRLLSKLGLLDTAVGFACDSGQFEFAMELCKFAGK-PTDEVHLKIAMSLEDEGKFEAAEAEFLKA 1166

Human  1169 GKPKEAVLMFVHNQDWEAAQRVAEAHDPDSVAEVLVGQARGALEEKDFQKAEGLLLRAQRPGLAL 1233
            .||:||:||:.|..||:||..|||.|.||:|.|||:|||..|||..:::..|.|||||.||.|.:
  Fly  1167 NKPREAILMYQHAGDWQAALNVAENHLPDAVGEVLIGQASAALETSNYKDYEALLLRAHRPDLII 1231

Human  1234 NYYKEAGLWSDALRICKDYVPS---QLEALQEEYER-----EATKKGARGVEGFVEQARHWEQAG 1290
            .:||:..|:.|||||.:::.||   .|..||.:.:|     :|.:..|.....::::|..:.:..
  Fly  1232 EHYKQESLYEDALRIAEEHYPSALNDLRRLQAQLQRGQAQAQAGEDAASISRSYLQKAAEFAKKE 1296

Human  1291 EYSRAVDCYLKVRDSGN---SGLAEKCWMKAAELSIKFLPPQRNMEVVLAVGPQLIGIGKHSAAA 1352
            ::.:|.:|.::: ||.|   :...|:..::|||:..:||..|...|:..::||:|:.|.:...||
  Fly  1297 QFRKAAECLMQI-DSSNAEDASTLERALLRAAEICNQFLEGQDAQELAQSLGPRLLAIKQIGPAA 1360

Human  1353 ELYLNLDLVKEAIDAFIEGEEWNKAKRVAKELDPRYE--DYVDQHYKEFLKNQGKVDSLVGVDVI 1415
            :|||..|:.|:|:|.||:.|:|:||:|:|||:||..:  .||:|..|..||::|.::.|..:|::
  Fly  1361 QLYLAADMPKQAVDVFIKTEQWSKARRLAKEIDPDLQLLAYVEQQQKASLKHEGNIEQLADIDIV 1425

Human  1416 AALDLYVEQGQWDKCIETATKQNYKILHKYVALYATHLIREGSSAQALALYVQHGAPANPQNFNI 1480
            :||||..|.|:|.:|:|.|...|..:|.||||:||..|||||:...||.||:.:|||....:|||
  Fly  1426 SALDLLAEHGEWQRCLEKAKGLNPALLQKYVAVYAAQLIREGNCTTALGLYLSYGAPPIEAHFNI 1490

Human  1481 YKRIFTDMV------SSPGTNCAEAYHSWADLRDVLFNLCENLVKSSEANS-----PAHEEFKTM 1534
            |.||..|.:      :..||       :|..|||.||.|.::| |::.|.|     .:.|:|
  Fly  1491 YTRIALDCLALREEQTERGT-------TWRQLRDFLFRLLQSL-KATPAQSQTKFAASMEQF--- 1544

Human  1535 LLIAHYYATRSAAQSVKQLETVAARLSVSLLRHTQLLPVDKAFYEAGIAAKAVGWDNMAFIFLNR 1599
            ||||||||||:|.:.|:.|:.||.|||::|||||.||||||.|||||:..:..|.:..||:.||.
  Fly  1545 LLIAHYYATRAACKEVQALQPVALRLSLALLRHTDLLPVDKGFYEAGMDLRQAGREAEAFVMLNH 1609

Human  1600 FLDLTDAIEEGTLDGLDHSDFQDTDIPFEVPLPAKQHVPE--AEREEVRDWVLTVSMDQRLEQVL 1662
            :||:.:|||||:...:||||...||.|..||||...|:..  :..||||:|||.|||||:::|.|
  Fly  1610 YLDVCEAIEEGSGQLVDHSDLASTDFPSSVPLPEDIHLKNDPSLHEEVREWVLAVSMDQQVDQQL 1674

Human  1663 PRDERGAYEASLVAASTGVRALPCLITGYPIL-RNKIEFKRPGKAANKDNWNKFLMAIKTSHSPV 1726
            |.|:||.||:||     |...|||:::|:|:. |..:.|:......|:|.|:||.:|:|.|....
  Fly  1675 PTDDRGLYESSL-----GPNDLPCMLSGFPVRGRQPVTFQGSSNQVNRDVWSKFSVALKMSPGSG 1734

Human  1727 CQDVLKFISQWCG 1739
            ..|::.|..:|.|
  Fly  1735 IADIISFTEKWQG 1747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IFT172	NP_056477.1	WD 1	14..53		17/38 (45%)
		WD40	17..388	CDD:225201	189/371 (51%)
		WD40	17..318	CDD:295369	159/300 (53%)
		WD40 repeat	20..64	CDD:293791	24/43 (56%)
		WD 2	64..103		24/38 (63%)
		WD40 repeat	69..110	CDD:293791	29/40 (73%)
		WD 3	110..148		18/37 (49%)
		WD40 repeat	116..148	CDD:293791	14/31 (45%)
		WD 4	150..191		21/40 (53%)
		WD40 repeat	155..194	CDD:293791	20/38 (53%)
		WD 5	195..233		18/37 (49%)
		WD40 repeat	200..248	CDD:293791	25/47 (53%)
		WD 6	238..278		21/39 (54%)
		WD 7	284..323		17/38 (45%)
		WD 8	483..520		23/36 (64%)
		WD 9	521..559		19/37 (51%)
		TPR 1	593..624		17/30 (57%)
		TPR 2	692..725		15/32 (47%)
		SNAP	808..>994	CDD:305195	80/186 (43%)
		TPR 3	809..842		15/32 (47%)
		TPR repeat	811..866	CDD:276937	27/54 (50%)
		TPR 4	854..887		21/32 (66%)
		TPR repeat	870..906	CDD:276937	22/35 (63%)
		TPR repeat	909..954	CDD:276937	11/45 (24%)
		TPR 5	912..945		8/33 (24%)
		TPR 6	947..970		6/22 (27%)
		TPR 7	971..1004		14/32 (44%)
		TPR 8	1042..1075		14/32 (44%)
		TPR 9	1142..1175		24/32 (75%)
		TPR 10	1276..1309		6/35 (17%)
		TPR 11	1345..1378		15/32 (47%)
		TPR 12	1411..1445		13/33 (39%)
		TPR 13	1447..1477		15/29 (52%)
		TPR 14	1574..1607		14/32 (44%)
Oseg2	NP_647700.2	WD40	18..313	CDD:295369	158/295 (54%)
		WD40	19..>325	CDD:225201	162/306 (53%)
		WD40 repeat	19..63	CDD:293791	24/43 (56%)
		WD40 repeat	70..106	CDD:293791	25/35 (71%)
		WD40 repeat	115..150	CDD:293791	15/34 (44%)
		WD40 repeat	156..194	CDD:293791	20/38 (53%)
		WD40 repeat	199..232	CDD:293791	15/32 (47%)
		WD40 repeat	244..281	CDD:293791	17/36 (47%)
		WD40 repeat	288..312	CDD:293791	10/23 (43%)
		PRK12798	<1212..1393	CDD:237211	62/181 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147340
Domainoid	1	1.000	1547	1.000	Domainoid score	I6
eggNOG	1	0.900	-	-		E1_KOG3616
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15202
Inparanoid	1	1.050	1628	1.000	Inparanoid score	I81
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56342
OrthoDB	1	1.010	-	-		D21469at33208
OrthoFinder	1	1.000	-	-		FOG0006527
OrthoInspector	1	1.000	-	-		oto91325
orthoMCL	1	0.900	-	-		OOG6_104287
Panther	1	1.100	-	-	LDO	PTHR15722
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2702
SonicParanoid	1	1.000	-	-		X5503
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800