DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl12 and Adgrl2

DIOPT Version :9

Sequence 1:NP_731791.2 Gene:mthl12 / 261599 FlyBaseID:FBgn0045442 Length:488 Species:Drosophila melanogaster
Sequence 2:XP_036019331.1 Gene:Adgrl2 / 99633 MGIID:2139714 Length:1494 Species:Mus musculus


Alignment Length:310 Identity:67/310 - (21%)
Similarity:115/310 - (37%) Gaps:106/310 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   220 LSVISVVGF----------ILTLAVYLSVEKLRNLLGKCLICSLFSMFMEYFIWTMDYFRLLQSI 274
            |:||:.||.          |.|...:..::..||.:.|.|..:|   |:..||:.:...:...:|
Mouse   852 LTVITWVGIVVSLVCLAICIFTFCFFRGLQSDRNTIHKNLCINL---FIAEFIFLIGIDKTKYTI 913

  Fly   275 -CSAAGYMKYFFSMSSYLWFSVVSFHLW----ELFTSLNRHEPQY---RFLIYNTFVWCTAAIP- 330
             |.....:.:||.::::.|..:....|:    |:|.|....:..|   .:|...|.|..:|||. 
Mouse   914 ACPVFAGLLHFFFLAAFSWMCLEGVQLYLMLVEVFESEYSRKKYYYVAGYLFPATVVGVSAAIDY 978

  Fly   331 ----TVVIFSMNQMWENDPGKSEWLPLVGYFGCSVKDWNSSSWFYSHIPIVILNSFNVIMFVLTA 391
                ||              ::.||.:..||     .|:    |...:..:||  .|:|..|:|.
Mouse   979 KSYGTV--------------QACWLHVDNYF-----IWS----FIGPVTFIIL--LNIIFLVITL 1018

  Fly   392 IYIWKVKKGVKSFAQHDERNTTCLEFNVQTY-----------------IQFVR--------LFLI 431
            ..:.|....:|.       :::.|| |:..|                 ..|::        |..:
Mouse  1019 CKMVKHSNTLKP-------DSSRLE-NINNYRVCDGYYNTDLPGYEDNKPFIKSWVLGAFALLCL 1075

  Fly   432 MGASWLLDQLTRLAEDSHLLL----DTIVLNLTVYLNAAF----GILIFV 473
            :|.:|           |..||    :|:|:   .||..||    |:.||:
Mouse  1076 LGLTW-----------SFGLLFVNEETVVM---AYLFTAFNAFQGLFIFI 1111

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl12NP_731791.2 Methuselah_N 27..209 CDD:284145
Adgrl2XP_036019331.1 Gal_Lectin 49..129 CDD:396628
OLF 143..399 CDD:413369
HormR 470..534 CDD:214468
GAIN 543..765 CDD:406802
GPS 789..841 CDD:197639
7tm_GPCRs 850..1130 CDD:421689 67/310 (22%)
TM helix 1 851..876 CDD:410628 7/23 (30%)
TM helix 2 885..907 CDD:410628 7/24 (29%)
TM helix 3 916..943 CDD:410628 4/26 (15%)
TM helix 4 955..975 CDD:410628 4/19 (21%)
TM helix 5 992..1021 CDD:410628 10/39 (26%)
TM helix 6 1037..1088 CDD:410628 9/61 (15%)
TM helix 7 1092..1117 CDD:410628 8/23 (35%)
Latrophilin 1129..1494 CDD:396778
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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