DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl12 and ADGRE5

DIOPT Version :9

Sequence 1:	NP_731791.2	Gene:	mthl12 / 261599	FlyBaseID:	FBgn0045442	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_510966.1	Gene:	ADGRE5 / 976	HGNCID:	1711	Length:	835	Species:	Homo sapiens

Alignment Length:	218	Identity:	43/218 - (19%)
Similarity:	79/218 - (36%)	Gaps:	64/218 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 AGYMKYFFSMSSYLWFSVVSFHLWELFTSLNRHEPQYRFLIYNTFVWCTAAIPTVVIFSMNQMWE 342
            ||.:.|.| ::::.|.|:....|:              ||:...|                   :
Human   616 AGLLHYCF-LAAFCWMSLEGLELY--------------FLVVRVF-------------------Q 646

  Fly   343 NDPGKSEWLPLVGY------FGCSVKDWN-------------SSSWFYSHI-PIVILNSFNVIMF 387
            .....:.||.|:||      .|.|...::             ...:.:|.: |:..:...|.::|
Human   647 GQGLSTRWLCLIGYGVPLLIVGVSAAIYSKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVIF 711

  Fly   388 VLTAIYIWKVKKGVKSFAQHDERNTTCLEFNVQTYIQFVRLFLIMGASWLLDQLTRLAEDSHLLL 452
            |.|   :||:   .:.|::.:.......:....|.....:||| :|.:|:....  :.:|..|:|
Human   712 VTT---VWKL---TQKFSEINPDMKKLKKARALTITAIAQLFL-LGCTWVFGLF--IFDDRSLVL 767

  Fly   453 DTIVLNLTVYLNAAFGILIFVLL 475
             |.|..:...|..||..|:..||
Human   768 -TYVFTILNCLQGAFLYLLHCLL 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145
ADGRE5	NP_510966.1	EGF_CA	64..99	CDD:284955
		EGF_CA	116..>148	CDD:214542
		EGF_CA	160..207	CDD:284955
		EGF_CA	209..243	CDD:284955
		GPS	493..536	CDD:280071
		7tm_2	544..782	CDD:278432	39/209 (19%)
		ProP	608..>785	CDD:223553	40/212 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	814..835
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810