DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl12 and ADGRG1

DIOPT Version :10

Sequence 1:NP_731791.2 Gene:mthl12 / 261599 FlyBaseID:FBgn0045442 Length:488 Species:Drosophila melanogaster
Sequence 2:XP_005256294.1 Gene:ADGRG1 / 9289 HGNCID:4512 Length:698 Species:Homo sapiens


Alignment Length:526 Identity:98/526 - (18%)
Similarity:179/526 - (34%) Gaps:181/526 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 DETINISHFK-----RLNDAYIYEHFEIPANLTGEFDYKELMDGSKV--PTEFPNLRGCICKVRP 87
            ::.||.:.:|     .|.|.:|:..        .|.:..|:|:.|.:  .|.|...:|       
Human   235 EDRINATVWKLQPTAGLQDLHIHSR--------QEEEQSEIMEYSVLLPRTLFQRTKG------- 284

  Fly    88 CIRICCARKNILSNGECSDGVKNEIKLTMLDLTMQDILL---TDPTLAE--LNMIPQ----YNST 143
                        .:||.      |.:|.::|.:.|.:..   :...|.|  |.::.|    .|.|
Human   285 ------------RSGEA------EKRLLLVDFSSQALFQDKNSSQVLGEKVLGIVVQNTKVANLT 331

  Fly   144 ELLILREQFQPCDEIVSLK----RDEYTILKDGSILLHTSAEILSNDQYCLYPEIYSDFPETI-R 203
            |.::|..|.|...:.|:|:    .::.|:...|    |.|:      ..|          ||: |
Human   332 EPVVLTFQHQLQPKNVTLQCVFWVEDPTLSSPG----HWSS------AGC----------ETVRR 376

  Fly   204 IINRRCYRNVMPGIA---------------QLSVISVVGFI-------LTLAVYLSV-------E 239
            .....|:.|.:...|               .||::|.||.:       :|:|.||..       .
Human   377 ETQTSCFCNHLTYFAVLMVSSVEVDAVHKHYLSLLSYVGCVVSALACLVTIAAYLCSRVPLPCRR 441

  Fly   240 KLRNLLGKCLICSLFSMFMEYFIWTMDYFRLL---------QSICSAAGYMKYFFSMSSYLWFSV 295
            |.|:...|..:..|.::|:      :|...||         ::.|.|:....:|..::...|..:
Human   442 KPRDYTIKVHMNLLLAVFL------LDTSFLLSEPVALTGSEAGCRASAIFLHFSLLTCLSWMGL 500

  Fly   296 VSFHLWELFTSL-NRHEPQYR------------FLI----------YNTFVWCTAAIPTVVIFSM 337
            ..::|:.|...: ..:.|.|.            ||:          |...:......|..||:. 
Human   501 EGYNLYRLVVEVFGTYVPGYLLKLSAMGWGFPIFLVTLVALVDVDNYGPIILAVHRTPEGVIYP- 564

  Fly   338 NQMWENDPGKSEWLPLVGYFGCSVKDWNSSSWFYSHIPIVILNSFNVIMFVLTAIYIWKVKKGVK 402
            :..|..|       .||.|.        ::...:|   :|.|  ||:.|.....:.|.:::...:
Human   565 SMCWIRD-------SLVSYI--------TNLGLFS---LVFL--FNMAMLATMVVQILRLRPHTQ 609

  Fly   403 SFAQHDERNTTCLEFNVQTYIQFVRLFLIMGASWLLDQLTRLAEDSHLLLDTIVLNLTVYLNAAF 467
            .::.               .:..:.|.|::|..|.|...:..:....|    :||.|...:.:..
Human   610 KWSH---------------VLTLLGLSLVLGLPWALIFFSFASGTFQL----VVLYLFSIITSFQ 655

  Fly   468 GILIFV 473
            |.|||:
Human   656 GFLIFI 661

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl12NP_731791.2 Methuselah_N 27..209 CDD:429053 39/199 (20%)
7tmB3_Methuselah-like 220..488 CDD:410632 56/300 (19%)
TM helix 2 246..268 CDD:410632 4/21 (19%)
TM helix 3 276..303 CDD:410632 4/26 (15%)
TM helix 4 316..336 CDD:410632 6/29 (21%)
TM helix 5 364..394 CDD:410632 6/29 (21%)
TM helix 6 410..444 CDD:410632 5/33 (15%)
TM helix 7 449..479 CDD:410632 8/25 (32%)
ADGRG1XP_005256294.1 PLL 34..167 CDD:436599
GAIN_A 178..225 CDD:436625
GPS 350..393 CDD:460350 11/62 (18%)
7tm_GPCRs 405..679 CDD:475119 56/303 (18%)
TM helix 1 408..432 CDD:320661 8/23 (35%)
TM helix 2 448..469 CDD:320661 6/26 (23%)
TM helix 3 481..503 CDD:320661 3/21 (14%)
TM helix 4 523..539 CDD:320661 2/15 (13%)
TM helix 5 572..595 CDD:320661 9/35 (26%)
TM helix 6 614..636 CDD:320661 5/21 (24%)
TM helix 7 642..667 CDD:320661 8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

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