Protein Alignment mthl12 and ADGRG1

DIOPT Version :9

• Sequence 1: NP_731791.2
• Gene: mthl12 / 261599
• FlyBaseID: FBgn0045442
• Length: 488
• Species: Drosophila melanogaster
• Sequence 2: XP_005256294.1
• Gene: ADGRG1 / 9289
• HGNCID: 4512
• Length: 698
• Species: Homo sapiens
• Alignment Length: 526
• Identity: 98/526 - (18%)
• Similarity: 179/526 - (34%)
• Gaps: 181/526 - (34%)

  Fly    30 DETINISHFK-----RLNDAYIYEHFEIPANLTGEFDYKELMDGSKV--PTEFPNLRGCICKVRP 87
            ::.||.:.:|     .|.|.:|:..        .|.:..|:|:.|.:  .|.|...:|
Human   235 EDRINATVWKLQPTAGLQDLHIHSR--------QEEEQSEIMEYSVLLPRTLFQRTKG------- 284

  Fly    88 CIRICCARKNILSNGECSDGVKNEIKLTMLDLTMQDILL---TDPTLAE--LNMIPQ----YNST 143
                        .:||.      |.:|.::|.:.|.:..   :...|.|  |.::.|    .|.|
Human   285 ------------RSGEA------EKRLLLVDFSSQALFQDKNSSQVLGEKVLGIVVQNTKVANLT 331

  Fly   144 ELLILREQFQPCDEIVSLK----RDEYTILKDGSILLHTSAEILSNDQYCLYPEIYSDFPETI-R 203
            |.::|..|.|...:.|:|:    .::.|:...|    |.|:      ..|          ||: |
Human   332 EPVVLTFQHQLQPKNVTLQCVFWVEDPTLSSPG----HWSS------AGC----------ETVRR 376

  Fly   204 IINRRCYRNVMPGIA---------------QLSVISVVGFI-------LTLAVYLSV-------E 239
            .....|:.|.:...|               .||::|.||.:       :|:|.||..       .
Human   377 ETQTSCFCNHLTYFAVLMVSSVEVDAVHKHYLSLLSYVGCVVSALACLVTIAAYLCSRVPLPCRR 441

  Fly   240 KLRNLLGKCLICSLFSMFMEYFIWTMDYFRLL---------QSICSAAGYMKYFFSMSSYLWFSV 295
            |.|:...|..:..|.::|:      :|...||         ::.|.|:....:|..::...|..:
Human   442 KPRDYTIKVHMNLLLAVFL------LDTSFLLSEPVALTGSEAGCRASAIFLHFSLLTCLSWMGL 500

  Fly   296 VSFHLWELFTSL-NRHEPQYR------------FLI----------YNTFVWCTAAIPTVVIFSM 337
            ..::|:.|...: ..:.|.|.            ||:          |...:......|..||:.
Human   501 EGYNLYRLVVEVFGTYVPGYLLKLSAMGWGFPIFLVTLVALVDVDNYGPIILAVHRTPEGVIYP- 564

  Fly   338 NQMWENDPGKSEWLPLVGYFGCSVKDWNSSSWFYSHIPIVILNSFNVIMFVLTAIYIWKVKKGVK 402
            :..|..|       .||.|.        ::...:|   :|.|  ||:.|.....:.|.:::...:
Human   565 SMCWIRD-------SLVSYI--------TNLGLFS---LVFL--FNMAMLATMVVQILRLRPHTQ 609

  Fly   403 SFAQHDERNTTCLEFNVQTYIQFVRLFLIMGASWLLDQLTRLAEDSHLLLDTIVLNLTVYLNAAF 467
            .::.               .:..:.|.|::|..|.|...:..:....|    :||.|...:.:..
Human   610 KWSH---------------VLTLLGLSLVLGLPWALIFFSFASGTFQL----VVLYLFSIITSFQ 655

  Fly   468 GILIFV 473
            |.|||:
Human   656 GFLIFI 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145	39/199 (20%)
ADGRG1	XP_005256294.1	GPS	349..393	CDD:280071	12/63 (19%)
		7tm_4	408..659	CDD:304433	53/296 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900