DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl12 and ADGRG7

DIOPT Version :9

Sequence 1:	NP_731791.2	Gene:	mthl12 / 261599	FlyBaseID:	FBgn0045442	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_116176.2	Gene:	ADGRG7 / 84873	HGNCID:	19241	Length:	797	Species:	Homo sapiens

Alignment Length:	337	Identity:	65/337 - (19%)
Similarity:	133/337 - (39%)	Gaps:	89/337 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 FPETIRIINRRCYRNVMPGIAQLSVISVVGFILTLAVYLSVEKLRN------LLGKCLICSLFSM 256
            :|:::.|::     ||  |.|    :||.|..||:...:...|:|.      |:..|:...:|::
Human   430 YPKSLDILS-----NV--GCA----LSVTGLALTVIFQIVTRKVRKTSVTWVLVNLCISMLIFNL 483

  Fly   257 FMEYFIWT------------------------MDYFRLLQSICSAAGYMKYFFSMSSYLWFSVVS 297
            ...:.|..                        .|...:...:|:|...:.::|.:.::.|.::.:
Human   484 LFVFGIENSNKNLQTSDGDINNIDFDNNDIPRTDTINIPNPMCTAIAALLHYFLLVTFTWNALSA 548

  Fly   298 FHLWELFTSLNRHEPQYRFLIYNTFVW----CTAAIPTVVIFSM---NQMWENDPGKSE--WL-- 351
            ..|:.|.....:..|::..|..:...|    ...||...||:|.   |..||.|..:.:  ||
Human   549 AQLYYLLIRTMKPLPRHFILFISLIGWGVPAIVVAITVGVIYSQNGNNPQWELDYRQEKICWLAI 613

  Fly   352 ---------PLVGYFGCSVKDWNSSSWFYSHIPIVILNSFNVIMFVLTAI-YIWKVKKGVKSFAQ 406
                     ||:              |.:. :|:.|:...||:||:..:| .:||..:.:.|
Human   614 PEPNGVIKSPLL--------------WSFI-VPVTIILISNVVMFITISIKVLWKNNQNLTS--- 660

  Fly   407 HDERNTTCLEFNVQTYIQFVRLFLIMGASWLLDQLTRLAEDSHLLLDTIVLNLTVYLNAAFGILI 471
                  |....:::..:..:.:.::.|.:|:|..|..:.:||..::.:.:..|   .|...|:.|
Human   661 ------TKKVSSMKKIVSTLSVAVVFGITWILAYLMLVNDDSIRIVFSYIFCL---FNTTQGLQI 716

  Fly   472 FVLLILKGSTFK 483
            |:|..::...|:
Human   717 FILYTVRTKVFQ 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145	2/10 (20%)
ADGRG7	NP_116176.2	GPS	383..422	CDD:197639
		7tmB2_GPR128	431..737	CDD:320385	65/336 (19%)
		TM helix 1	433..458	CDD:320385	10/35 (29%)
		TM helix 2	468..490	CDD:320385	3/21 (14%)
		TM helix 3	527..554	CDD:320385	4/26 (15%)
		TM helix 4	567..587	CDD:320385	4/19 (21%)
		TM helix 5	621..651	CDD:320385	10/44 (23%)
		TM helix 6	665..692	CDD:320385	4/26 (15%)
		TM helix 7	699..724	CDD:320385	6/27 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810