DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl12 and ADGRE3

DIOPT Version :10

Sequence 1:NP_731791.2 Gene:mthl12 / 261599 FlyBaseID:FBgn0045442 Length:488 Species:Drosophila melanogaster
Sequence 2:NP_115960.2 Gene:ADGRE3 / 84658 HGNCID:23647 Length:652 Species:Homo sapiens


Alignment Length:290 Identity:61/290 - (21%)
Similarity:114/290 - (39%) Gaps:77/290 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   220 LSVISVVG-------FILTLAVYLSVEKLRNL-------LGKCLICSLFSMFMEYFIWTMDYFRL 270
            |:||:.||       .:|....:|..:.:||.       |..||       |:.:.::.:...|.
Human   356 LTVITYVGLSVSLLCLLLAALTFLLCKAIRNTSTSLHLQLSLCL-------FLAHLLFLVGIDRT 413

  Fly   271 LQSI-CS-AAGYMKYFFSMSSYLWFSVVSFHLWEL--------FTSLNRHEPQYRFLI-YNTFVW 324
            ...: || .||.:.|.: ::::.|..:...||:..        ::|:||......|.: |     
Human   414 EPKVLCSIIAGALHYLY-LAAFTWMLLEGVHLFLTARNLTVVNYSSINRLMKWIMFPVGY----- 472

  Fly   325 CTAAIPTVVIFSMNQMWENDPGKSE--WLPLVGYFGCSVKDWNSSSWFYSHI-PIVILNSFNVIM 386
               .:|.|.:......|.:..|.::  ||.|            ...:.:|.: |:..:.|.|:::
Human   473 ---GVPAVTVAISAASWPHLYGTADRCWLHL------------DQGFMWSFLGPVCAIFSANLVL 522

  Fly   387 FVLTAIYIWKVKKGVKSFAQHDE--RNTTCLEFNVQTYIQFVRLFLIMGASWLLD--QLTRLAED 447
            |:|.   .|.:|:.:.|......  :||..|.|...     .:|| |:|.:|.|.  |:...|: 
Human   523 FILV---FWILKRKLSSLNSEVSTIQNTRMLAFKAT-----AQLF-ILGCTWCLGLLQVGPAAQ- 577

  Fly   448 SHLLLDTIVLNLTVYLNAAFGILIFVLLIL 477
                   ::..|...:|:..|..||::..|
Human   578 -------VMAYLFTIINSLQGFFIFLVYCL 600

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl12NP_731791.2 Methuselah_N 27..209 CDD:429053
7tmB3_Methuselah-like 220..488 CDD:410632 61/290 (21%)
TM helix 2 246..268 CDD:410632 3/21 (14%)
TM helix 3 276..303 CDD:410632 7/27 (26%)
TM helix 4 316..336 CDD:410632 4/20 (20%)
TM helix 5 364..394 CDD:410632 6/30 (20%)
TM helix 6 410..444 CDD:410632 11/35 (31%)
TM helix 7 449..479 CDD:410632 6/29 (21%)
ADGRE3NP_115960.2 EGF_CA 67..104 CDD:238011
GPS 304..344 CDD:460350
7tm_GPCRs 353..614 CDD:475119 61/290 (21%)
TM helix 1 356..380 CDD:410628 6/23 (26%)
TM helix 2 389..410 CDD:410628 4/27 (15%)
TM helix 3 420..442 CDD:410628 5/22 (23%)
TM helix 4 466..482 CDD:410628 4/23 (17%)
TM helix 5 501..524 CDD:410628 4/22 (18%)
TM helix 6 551..573 CDD:410628 8/27 (30%)
TM helix 7 577..602 CDD:410628 6/32 (19%)
Blue background indicates that the domain is not in the aligned region.

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