DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl12 and ADGRE3

DIOPT Version :9

Sequence 1:	NP_731791.2	Gene:	mthl12 / 261599	FlyBaseID:	FBgn0045442	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_115960.2	Gene:	ADGRE3 / 84658	HGNCID:	23647	Length:	652	Species:	Homo sapiens

Alignment Length:	290	Identity:	61/290 - (21%)
Similarity:	114/290 - (39%)	Gaps:	77/290 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 LSVISVVG-------FILTLAVYLSVEKLRNL-------LGKCLICSLFSMFMEYFIWTMDYFRL 270
            |:||:.||       .:|....:|..:.:||.       |..||       |:.:.::.:...|.
Human   356 LTVITYVGLSVSLLCLLLAALTFLLCKAIRNTSTSLHLQLSLCL-------FLAHLLFLVGIDRT 413

  Fly   271 LQSI-CS-AAGYMKYFFSMSSYLWFSVVSFHLWEL--------FTSLNRHEPQYRFLI-YNTFVW 324
            ...: || .||.:.|.: ::::.|..:...||:..        ::|:||......|.: |
Human   414 EPKVLCSIIAGALHYLY-LAAFTWMLLEGVHLFLTARNLTVVNYSSINRLMKWIMFPVGY----- 472

  Fly   325 CTAAIPTVVIFSMNQMWENDPGKSE--WLPLVGYFGCSVKDWNSSSWFYSHI-PIVILNSFNVIM 386
               .:|.|.:......|.:..|.::  ||.|            ...:.:|.: |:..:.|.|:::
Human   473 ---GVPAVTVAISAASWPHLYGTADRCWLHL------------DQGFMWSFLGPVCAIFSANLVL 522

  Fly   387 FVLTAIYIWKVKKGVKSFAQHDE--RNTTCLEFNVQTYIQFVRLFLIMGASWLLD--QLTRLAED 447
            |:|.   .|.:|:.:.|......  :||..|.|...     .:|| |:|.:|.|.  |:...|:
Human   523 FILV---FWILKRKLSSLNSEVSTIQNTRMLAFKAT-----AQLF-ILGCTWCLGLLQVGPAAQ- 577

  Fly   448 SHLLLDTIVLNLTVYLNAAFGILIFVLLIL 477
                   ::..|...:|:..|..||::..|
Human   578 -------VMAYLFTIINSLQGFFIFLVYCL 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145
ADGRE3	NP_115960.2	EGF_CA	67..104	CDD:238011
		GPS	304..344	CDD:280071
		7tm_4	353..594	CDD:304433	58/282 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810