DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl12 and adgrg4a

DIOPT Version :9

Sequence 1:NP_731791.2 Gene:mthl12 / 261599 FlyBaseID:FBgn0045442 Length:488 Species:Drosophila melanogaster
Sequence 2:XP_021336868.1 Gene:adgrg4a / 793963 ZFINID:ZDB-GENE-121129-2 Length:1201 Species:Danio rerio


Alignment Length:291 Identity:63/291 - (21%)
Similarity:118/291 - (40%) Gaps:72/291 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   220 LSVISVVG------FI-LTLAVYLSVEKLRN------LLGKCLICSLFSMFMEYFI--WTMDYFR 269
            |::||.||      |: :||..||:.||||.      |:..|:  :|..:.|.:.:  |...:..
Zfish   874 LTIISYVGCGISSIFLGVTLLTYLAFEKLRRDYPSKILINLCM--ALLGLNMLFLVNSWFASFNS 936

  Fly   270 LLQSICSAAGYMKYFFSMSSYLWFSVVSFHLW-ELFTSLNRHEPQYRFLIYNTFVWCTAAIPTVV 333
              .::|......:::|.::::.|..:.:.::: .|....|.:.|.| .|.:....|   .||..|
Zfish   937 --NALCITVAAFQHYFFLATFTWMGLGAINMYLALVKVFNSYVPSY-ILKFCAVGW---GIPLSV 995

  Fly   334 IFSMNQMWENDPGKSEWLPLVGYFGCSVKDWNSSSWFYSHIPI-VILNSF-------NVIMFVLT 390
            :..:..:..|..|.|....|       :::..:..||.:.:.. |.:.||       |:|:||:.
Zfish   996 VILVLAIDFNSYGTSLSTDL-------LQESTAFCWFKNDVTFYVTVVSFAILIMVCNIIVFVVV 1053

  Fly   391 AIYIWKVKKGVKSFAQ----HDERNTTCLEFNVQTYIQFVRLFLIMGASWLLDQLTRLAEDSHLL 451
            .:.|.|::....|.::    ||.|....|.|             ::|.:|:|           :.
Zfish  1054 LVQIHKMRVNKPSSSRKGFLHDLRVVASLTF-------------LLGLTWIL-----------VF 1094

  Fly   452 L-----DTIVLNLTVYLNAAFGILIFVLLIL 477
            .     .|.::.|...||:..|..||:...|
Zfish  1095 FGWGPAKTPLMYLFSILNSLQGFFIFLFYCL 1125

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl12NP_731791.2 Methuselah_N 27..209 CDD:284145
adgrg4aXP_021336868.1 LamG 50..210 CDD:328935
HsdR <637..>729 CDD:333053
GPS 815..858 CDD:307782
7tmB2_GPR112 871..1138 CDD:320663 63/291 (22%)
TM helix 1 873..898 CDD:320663 9/23 (39%)
TM helix 2 908..930 CDD:320663 4/23 (17%)
TM helix 3 941..968 CDD:320663 2/26 (8%)
TM helix 4 983..999 CDD:320663 4/18 (22%)
TM helix 5 1028..1051 CDD:320663 5/22 (23%)
TM helix 6 1073..1098 CDD:320663 8/48 (17%)
TM helix 7 1102..1127 CDD:320663 8/24 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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