Protein Alignment mthl12 and adgre5b.3

DIOPT Version :9

• Sequence 1: NP_731791.2
• Gene: mthl12 / 261599
• FlyBaseID: FBgn0045442
• Length: 488
• Species: Drosophila melanogaster
• Sequence 2: XP_005160275.1
• Gene: adgre5b.3 / 792970
• ZFINID: ZDB-GENE-121214-275
• Length: 756
• Species: Danio rerio
• Alignment Length: 602
• Identity: 105/602 - (17%)
• Similarity: 187/602 - (31%)
• Gaps: 253/602 - (42%)

  Fly    17 AKNSSAKIPHCKYDETINISHFKRLNDAYIYEHFEIPANLTGEFDYKELMDGSKVPTEFPNLRGC 81
            |.|:..|:.|..   ::.::..|.|||.: .|||      |.|    :|::
Zfish   210 AGNTPEKLKHLM---SLLMNSCKSLNDPH-GEHF------TAE----KLLE-------------- 246

  Fly    82 ICKVRPCIRICCARKNILSNGECSDGVKNEIKLTMLDLTMQDILLTDPTLAE--LNMIPQYNSTE 144
                    .:|.:..::||.|..:||   |.....||.....:.|..|.|.:  ..|..|....|
Zfish   247 --------NLCNSTDDLLSEGNVADG---ETLSVFLDAVENSMRLIGPQLKDPVTKMETQNTYAE 300

  Fly   145 LLILREQFQPCDEIVSLKRDEYTILKDGSILLHTSAEILSNDQYCLYPEI----YSDF------- 198
            :.:.|.|..|...:.         |..||...:||.|.:....|..:..:    |.|.
Zfish   301 VAVTRNQTPPSGSVT---------LSTGSAHFNTSWETVVGKSYPGFAFVALVSYKDMNSSSDLF 356

  Fly   199 ------------------------------PET-------IRIINRRCYRNVMPGIA-------- 218
                                          |:|       ..|......|....|:|
Zfish   357 NSMAREKSDVKEKQITYKLNSKVVTAVVSNPDTKHLSKPVTLIFTHEEKRAESEGVAYSCVYWSE 421

  Fly   219 -------------------------------------------QLSVISVVGFILTLAVYL---- 236
                                                       :|.||:.||.:|:|...:
Zfish   422 SERGWSGRGCELAWSNSTHTACSCSHLSSFAVLMALYPVEDTFELVVITRVGLVLSLICLILCIL 486

  Fly   237 ------SVEKLRNL----LGKCL-------ICSLFSMFMEYFIWTMDYFRLLQSICSAAGYMKYF 284
                  |::..||.    |..||       :|.:.|...             |..|:....:.:|
Zfish   487 TFRFCRSIQGTRNSIHLHLSVCLFIADLVFLCGISSTHN-------------QVACAIVAGLLHF 538

  Fly   285 FSMSSYLWFSVVSFHLWELFTSLNRHEPQYRFLIYNT-----FVWCTA-AIPTVVI----FSMNQ 339
            |.:|::.|..:....|:.:..           |:::|     :::... .:|.|::    .::.:
Zfish   539 FFLSAFCWMLLEGVQLYRMVV-----------LVFHTTLKHLYMYAVGYGVPLVIVSISAIAVPK 592

  Fly   340 MWENDPGKSEWLPLVGYFGCSVKDWNSSSWFYSHIPIVILNSFNVIMFVLTAIYIWKVKKGVKSF 404
            .:..|  :..||.|.||...|         |:  ||:.|:...|:.:|::|   :||:
Zfish   593 GYGTD--RHCWLSLEGYLILS---------FF--IPVCIIVILNITVFIIT---VWKL------- 634

  Fly   405 AQHDERNTTCLEFNV----QTYIQFVRLFL--------IMGASWLLDQLTRLAEDSHLLLDTIVL 457
                     .|:|:.    .:.:..:|.||        ::|.||:..........:.     ::|
Zfish   635 ---------ALKFSSLNPDLSKLHKIRSFLATAVAQLCVLGGSWVFGFFLFQKNGTE-----VML 685

  Fly   458 NLTVYLNAAFGILIFVL 474
            .|.:.||:..|.|||::
Zfish   686 YLFIILNSLQGALIFIM 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145	40/231 (17%)
adgre5b.3	XP_005160275.1	EGF_CA	32..>62	CDD:214542
		EGF_CA	72..105	CDD:214542
		EGF_CA	<121..152	CDD:214542
		EGF_CA	154..188	CDD:214542
		GPS	416..460	CDD:197639	0/43 (0%)
		7tm_2	466..699	CDD:278432	55/293 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910