Protein Alignment mthl12 and Adgrf1

DIOPT Version :9

• Sequence 1: NP_731791.2
• Gene: mthl12 / 261599
• FlyBaseID: FBgn0045442
• Length: 488
• Species: Drosophila melanogaster
• Sequence 2: XP_006525183.1
• Gene: Adgrf1 / 77596
• MGIID: 1924846
• Length: 927
• Species: Mus musculus
• Alignment Length: 562
• Identity: 106/562 - (18%)
• Similarity: 196/562 - (34%)
• Gaps: 192/562 - (34%)

  Fly    12 IIVTIAKNSSAKIPHCKYDETINISHFKRLNDAYIYEHFEIPANLTGEF-DYK------------ 63
            |::..||::|:::  .|..|:|          :.:.....:|.|.:|:| |:|
Mouse   410 ILLQDAKDASSQL--LKTLESI----------SSLIPSMALPLNFSGKFIDWKGTPVTQIQSTRG 462

  Fly    64 -----ELMDGSKVPTEFPNLRGCIC-------KVRPCIRICCARKNILSNGECSDGVKNEIKLTM 116
                 |:...:.:|     :||.:.       |..|        |.|:|               |
Mouse   463 YNYQMEMRQNASLP-----IRGHVFIEPDQFQKSHP--------KTIIS---------------M 499

  Fly   117 LDLTMQDIL---------LTDPTLAELNMIPQYNSTELLILREQFQPCDEIVSLKRDEYTILKDG 172
            ..||..|||         :..|.::.|  |..|:.:|:.:   .|......::..|   .:..|.
Mouse   500 ASLTFGDILPITQRGNAWVNGPVISTL--IQNYSISEIFL---NFSKIKGNLTQPR---CVFWDF 556

  Fly   173 SILLHTSAEI-LSNDQYCLYPEIYSDFPETIRIINRRC-----YRNVMPGIAQLSVISVVGFILT 231
            |.|..::|.. |.|              ||:..:..||     :..:|......||:.||.:|..
Mouse   557 SQLQWSNAGCQLVN--------------ETLDTVLCRCSHLTSFSMLMSPFVPSSVVPVVKWITY 607

  Fly   232 LAVYLSVEKL----------------------RNLLGKCLICSLFSMFMEYFIW-----TMDYFR 269
            :.:.:|:..|                      ||:   ||:....|:.:. .:|     |:|...
Mouse   608 IGLSISIASLILCLIIESLFWKQTKRSQTSYTRNI---CLVNIAVSLLIA-DVWFIIAATVDPSV 668

  Fly   270 LLQSICSAAGYMKYFFSMSSYLWFSVVS----------FHLWELFTSLNRHEPQYRFLI-YNTFV 323
            ....:|.||.:..:||.::.:.|..|:.          ||...|.|.:     ...|.: |.
Mouse   669 SPSGVCVAAVFFTHFFYLAVFFWMLVLGILLAYRIILVFHHMALTTMM-----AIGFCLGYG--- 725

  Fly   324 WCTAAIPTVVI--------FSMNQM-WENDPGKSEWLPLVGYFGCSVKDWNSSSWFYSHIPIVIL 379
             |...|..:.:        :..|.: |.|...||:  ||:.:.                :|.:.:
Mouse   726 -CPLLISIITLAVTQPSNSYKRNDVCWLNWSDKSK--PLLAFV----------------VPALTI 771

  Fly   380 NSFNVIMFVLTAIYIWKVKKGVKSFAQHDERNTTCLEFNVQTYIQFVRLFLIMGASWLLDQLTRL 444
            .:.|:::.:|....:|:...|.:  ...|::.|.     ::.....:.|..::|.:|.....|
Mouse   772 VAVNLVVVLLVLRKLWRPAVGER--LNQDDKATA-----IRMGKSLLVLTPLLGLTWGFGIGT-- 827

  Fly   445 AEDSHLLLDTIVLNLTVYLNAAFGILIFVLLILKGSTFKMIM 486
            ..:||.|...::..|   |||..|..||...||..:..:.::
Mouse   828 MANSHNLAWHVLFAL---LNAFQGFFIFCFGILLDTKLRQLL 866

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145	39/216 (18%)
Adgrf1	XP_006525183.1	SEA	172..258	CDD:366610
		GPS	549..590	CDD:197639	11/57 (19%)
		7tm_GPCRs	603..866	CDD:391938	56/305 (18%)
		TM helix 1	603..626	CDD:341315	3/22 (14%)
		TM helix 2	641..663	CDD:341315	5/25 (20%)
		TM helix 3	675..702	CDD:341315	6/26 (23%)
		TM helix 4	716..736	CDD:341315	4/28 (14%)
		TM helix 5	757..786	CDD:341315	7/46 (15%)
		TM helix 6	803..829	CDD:341315	4/32 (13%)
		TM helix 7	834..859	CDD:341315	10/27 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900