DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl12 and Adgrl4

DIOPT Version :10

Sequence 1:NP_731791.2 Gene:mthl12 / 261599 FlyBaseID:FBgn0045442 Length:488 Species:Drosophila melanogaster
Sequence 2:NP_071630.1 Gene:Adgrl4 / 64124 RGDID:621136 Length:738 Species:Rattus norvegicus


Alignment Length:495 Identity:107/495 - (21%)
Similarity:193/495 - (38%) Gaps:107/495 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 HFKRLNDAYIYEHFEIPANL--TGEFDYKE--------LMDGSKVPTEFP--NLRGCICKVRP-- 87
            |..:|..|..:...:|..|:  ..:||...        :.|...:....|  |:.|...|:.|  
  Rat   269 HLTKLMHAAEHVTLQISQNIQKNTQFDMNSTDLALKVFVFDSVHMKHTHPHMNVDGGYVKISPRR 333

  Fly    88 ----------CIRICCARK--NILSN------GECSDGVKNEIKLTMLDLTMQDILLTDPTLAEL 134
                      .:...|.|.  .:||:      |..||..|.:.|: :..:....|....|||.||
  Rat   334 KSAYDPNGNVIVAFLCYRSIGPLLSSSDDFLLGAQSDNSKGKEKV-ISSVISASISSNPPTLYEL 397

  Fly   135 NMIPQYNSTELLILREQFQPC-------DEI----VSLKRDEYTILKDGSILLHTSAEILSNDQY 188
            ..|....|...|..:.|.| |       |::    .|.:..|.|...|    .|||..       
  Rat   398 EKITFTLSHVKLSDKHQTQ-CAFWNYSVDDMNNGSWSSEGCELTYSND----THTSCR------- 450

  Fly   189 CLYPEIYSDFPETIRIINRRCYRNVMPGIAQL----SVISVVGFILTLAVYLSVEKLRNLLGKCL 249
            |.:...::........|..:.| |::..|.||    |:|.:...|.|...:..::..|..:.|.|
  Rat   451 CSHLTHFAILMSPSTSIEVKDY-NILTRITQLGIIISLICLAICIFTFWFFSEIQSTRTTIHKNL 514

  Fly   250 ICSLFSMFMEYFIW-TMDYFRLLQSICSAAGYMKYFFSMSSYLWFSVVSFHLWELFTSLNRHEPQ 313
            .||||...:.:.:. .::..:|:.||  .||.:.||| ::::.|..:...:|:.:...|..::  
  Rat   515 CCSLFLAQLVFLVGININTNKLVCSI--IAGLLHYFF-LAAFAWMCIEGIYLYLIVVGLIYNK-- 574

  Fly   314 YRFLIYNTFVWCTAAIPTVVIFSMNQMWENDPGKSEWLPLVGYFGCSVKDWNS--SSWFYSHI-P 375
             .||..|.:::...:...||.||.:..:.             |:|.:...|.|  :::.:|.| |
  Rat   575 -GFLHKNFYIFGYLSPAVVVGFSASLGYR-------------YYGTTKVCWLSTENNFIWSFIGP 625

  Fly   376 IVILNSFNVIMFVLTAIYIWKVKKGVKSFAQHDERNTTCLEFNVQTYIQ-FVRLFLIMGASWLLD 439
            ..::...|::.|.:....:::...|:|.       ..:|.| |:::..: .:.|..::|.:|...
  Rat   626 ACLIILVNLLAFGVIIYKVFRHTAGLKP-------EVSCYE-NIRSCARGALALLFLLGTTWTFG 682

  Fly   440 QLTRLAEDSHLLLDTIVLNLTVYL----NAAFGILIFVLL 475
            .|       |::..::|   |.||    ||..|:.||:.|
  Rat   683 VL-------HVVHASVV---TAYLFTVSNAFQGMFIFLFL 712

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl12NP_731791.2 Methuselah_N 27..209 CDD:429053 44/214 (21%)
7tmB3_Methuselah-like 220..488 CDD:410632 59/269 (22%)
TM helix 2 246..268 CDD:410632 6/22 (27%)
TM helix 3 276..303 CDD:410632 7/26 (27%)
TM helix 4 316..336 CDD:410632 5/19 (26%)
TM helix 5 364..394 CDD:410632 7/32 (22%)
TM helix 6 410..444 CDD:410632 7/34 (21%)
TM helix 7 449..479 CDD:410632 11/31 (35%)
Adgrl4NP_071630.1 EGF_CA 57..90 CDD:214542
EGF_CA 107..140 CDD:214542
GAIN 186..361 CDD:465137 17/91 (19%)
GPS 416..460 CDD:460350 11/55 (20%)
GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098 417..467 10/60 (17%)
7tmB2_ETL 472..729 CDD:320553 63/279 (23%)
TM helix 1 474..499 CDD:320553 7/24 (29%)
TM helix 2 508..530 CDD:320553 6/21 (29%)
TM helix 3 539..566 CDD:320553 9/29 (31%)
TM helix 4 578..598 CDD:320553 5/19 (26%)
TM helix 5 615..644 CDD:320553 5/28 (18%)
TM helix 6 660..687 CDD:320553 6/33 (18%)
TM helix 7 691..716 CDD:320553 10/25 (40%)
Blue background indicates that the domain is not in the aligned region.

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