Protein Alignment mthl12 and ADGRG6

DIOPT Version :9

• Sequence 1: NP_731791.2
• Gene: mthl12 / 261599
• FlyBaseID: FBgn0045442
• Length: 488
• Species: Drosophila melanogaster
• Sequence 2: XP_006715579.1
• Gene: ADGRG6 / 57211
• HGNCID: 13841
• Length: 1251
• Species: Homo sapiens
• Alignment Length: 491
• Identity: 92/491 - (18%)
• Similarity: 171/491 - (34%)
• Gaps: 158/491 - (32%)

  Fly    16 IAKNSSAKIPHCKYDETINISHFK----RLNDAYIYEHFE-----------IPANLTGEFDYKEL 65
            :|.:.|:.:|     .|..||:|.    ..|::|....||           :|.||......::.
Human   680 LALSVSSLLP-----GTNAISNFSIGLPSNNESYFQMDFESGQVDPLASVILPPNLLENLSPEDS 739

  Fly    66 MDGSKVPTEFPNLRGCICKVRPCIRICCARKNILSN-GECSDGVKNEIKLTMLDLTMQDILLTDP 129
            :...:....|.|..|....|.|      .||.::|. ..||.|          ::|:|:  |.||
Human   740 VLVRRAQFTFFNKTGLFQDVGP------QRKTLVSYVMACSIG----------NITIQN--LKDP 786

  Fly   130 TLAELNMIPQYNSTELLILREQFQPCDEIVSLKRDEYTILKDGSILLHTSAEILSNDQYCLYPEI 194
            ...::    ::..|:     |...|......|.:::    ..|.  .:||..:...|
Human   787 VQIKI----KHTRTQ-----EVHHPICAFWDLNKNK----SFGG--WNTSGCVAHRD-------- 828

  Fly   195 YSDFPETIRIINRRCYRNVMPGIAQ------------LSVISVVG-------FILTLAVYLSVEK 240
             ||..||:.:.|...:..|:..:.:            |:.||.:|       ...||..|::.||
Human   829 -SDASETVCLCNHFTHFGVLMDLPRSASQLDARNTKVLTFISYIGCGISAIFSAATLLTYVAFEK 892

  Fly   241 LRNLLGKCLICSLFS--MFMEYFI----WTMDYFRLLQSICSAAGYMKYFFSMSSYLWFSVVSFH 299
            ||......::.:|.:  :|:....    |...:  .:..:|.|...:.:||.::::.|..:.:.|
Human   893 LRRDYPSKILMNLSTALLFLNLLFLLDGWITSF--NVDGLCIAVAVLLHFFLLATFTWMGLEAIH 955

  Fly   300 LWELFTSLNRHEPQYRFLIYNTFV-----------W-CTAAIPTVVIFSMNQ------------- 339
            ::.....           ::||::           | ..|.:.:||:.|.|.
Human   956 MYIALVK-----------VFNTYIRRYILKFCIIGWGLPALVVSVVLASRNNNEVYGKESYGKEK 1009

  Fly   340 ----MWENDPGKSEWLPLVGYFGCSVKDWNSSSWFYSHIPIVILNSFNVIMFVLTAIYIWKVKKG 400
                .|..|| ...::...||||                   ::...|:.||::..:.|.. :.|
Human  1010 GDEFCWIQDP-VIFYVTCAGYFG-------------------VMFFLNIAMFIVVMVQICG-RNG 1053

  Fly   401 VKSFAQHDERNTTCLEFNVQTYIQFVRLFLIMGASW 436
            .:|       |.|..|..::.....|.|..::|.:|
Human  1054 KRS-------NRTLREEVLRNLRSVVSLTFLLGMTW 1082

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145	40/197 (20%)
ADGRG6	XP_006715579.1	CUB	44..147	CDD:238001
		LamG	154..338	CDD:304605
		GPS	802..847	CDD:280071	11/59 (19%)
		7tm_4	864..1111	CDD:304433	48/260 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810