DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl12 and adgrd2

DIOPT Version :9

Sequence 1:	NP_731791.2	Gene:	mthl12 / 261599	FlyBaseID:	FBgn0045442	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	XP_021334184.1	Gene:	adgrd2 / 571770	ZFINID:	ZDB-GENE-081104-190	Length:	1145	Species:	Danio rerio

Alignment Length:	354	Identity:	73/354 - (20%)
Similarity:	140/354 - (39%)	Gaps:	73/354 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 EYTILKDGS-------ILLHTSAEILSNDQYC-------LYPEIYSDFPETIRIINRRCYRNVMP 215
            ::.::.||.       :::.|...  |...||       |..:||.        :.|....:
Zfish   741 DFDLMSDGGGWSTKGCVVISTQNN--STSCYCNHTTNFALLLQIYE--------VQRDAVHD--- 792

  Fly   216 GIAQLSVISVVG-----------FILTLAVYLSVEKL-RNLLGKCLICSLFSMFMEYFIWTMDYF 268
              |.|.::|::|           |||.:||  .|.|. |..:.|.|:.:|  :..::.:...|:.
Zfish   793 --AGLQILSLIGSAVSLCALIFTFILFVAV--GVPKSDRTTVHKNLMAAL--IVAQFLLILSDWA 851

  Fly   269 RLLQSICSAAGYMKYFFSMSSYLWFSVVSFHLWELFTSLNRHEPQYRFLIYNTFVWCTAAIPTVV 333
            ...|..|.....:.:.|.:||:.|..|....||....|:|..|.: |..:|....|   .:| ||
Zfish   852 AGSQEACWLVTALLHLFFLSSFCWMLVEGLLLWSKVVSVNISEDR-RMKMYYVLGW---GLP-VV 911

  Fly   334 IFSMNQMWENDPGKSE---WLPLVGYFGCSVKDWNSSSWFYSHIPIVILNSFN-VIMFVLTAIYI 394
            |.::..:...|..|::   ||.|          .:|..|.::. |::.:.:.| |::|.:..:.:
Zfish   912 IVAVTLVATLDQYKAQQHCWLNL----------QSSVIWAFAG-PVLFVLAVNAVVLFRVVLVTV 965

  Fly   395 WKVKKGVKSFAQHDERNTTCLEFNVQTYIQFVRLFLIMGASWLLDQLTRLAEDSHLLLDTIVLNL 459
            ...::..|......:.....|:.........:.|..::|.:||...|..|::        ::..|
Zfish   966 SSARRRAKMLTPSSDSKLHTLDLTWAATRPVLILLPVLGLTWLCGVLVHLSD--------VMAYL 1022

  Fly   460 TVYLNAAFGILIFVLLILKGSTFKMIMER 488
            .:.|||..|:.||::..:..|..:..:.|
Zfish  1023 FITLNAFQGLYIFLVYAVYNSEVRNAIRR 1051

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145	10/57 (18%)
adgrd2	XP_021334184.1	LamG	204..402	CDD:328935
		GPS	735..779	CDD:307782	6/39 (15%)
		7tmB2_GPR144	792..1054	CDD:320383	63/293 (22%)
		TM helix 1	794..819	CDD:320383	6/24 (25%)
		TM helix 2	828..850	CDD:320383	3/23 (13%)
		TM helix 3	859..886	CDD:320383	7/26 (27%)
		TM helix 4	898..918	CDD:320383	6/23 (26%)
		TM helix 5	935..964	CDD:320383	6/29 (21%)
		TM helix 6	988..1015	CDD:320383	5/26 (19%)
		TM helix 7	1017..1042	CDD:320383	7/32 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910