DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mthl12 and adgre10

DIOPT Version :9

Sequence 1:NP_731791.2 Gene:mthl12 / 261599 FlyBaseID:FBgn0045442 Length:488 Species:Drosophila melanogaster
Sequence 2:XP_021333746.1 Gene:adgre10 / 569655 ZFINID:ZDB-GENE-090313-152 Length:690 Species:Danio rerio


Alignment Length:458 Identity:94/458 - (20%)
Similarity:170/458 - (37%) Gaps:134/458 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   112 IKLT----MLDLTMQD----ILLTDPTLAELNMIPQYNSTELLILREQFQPCDEIVSLKRDEYTI 168
            :|||    .:..|:::    :.:..|.:. ||.|.|.|:|      ..|...|.|...|.::.|.
Zfish   237 VKLTDTSANVSFTLENVEGHVFMVGPNVT-LNEILQLNTT------NSFMDIDLIGIAKNNKDTR 294

  Fly   169 LKDGSILLHTSAEILSNDQYCLYPEIYSDFPETIRIINRRCYRNV----MPGIAQLSVISVVGFI 229
            ....:.:.:|..|.|          :.:||..|.:..|:.....|    :|..:..::...|.|.
Zfish   295 SAAVAFMSYTIMENL----------LKADFFNTQKNTNKTMMSTVISATLPKTSNTALTKPVNFT 349

  Fly   230 L-----------TLAVYLSVEK------------LRNLLGKCLICSLFSMFMEYFIWT------M 265
            .           ...||.::.:            ..:.:..|:..|.|::.|:    |      .
Zfish   350 FRHIREFDPSGSLSCVYWNISEWIVDGCSVLNSNSSHTVCSCVHLSTFALIMQ----TSSSPPPS 410

  Fly   266 DYFRLLQSICSAAGYMKYFFSMSSYL---W-------------FSVVSFHLWELFTS--LNRHEP 312
            |...||..:|...|.:.:..::.|:.   |             .|::|.||..|.|.  |:...|
Zfish   411 DLLDLLNLVCVIVGLVFFSLALLSFALCQWSPGVNNVARINICISLLSAHLLLLLTQQFLSLIRP 475

  Fly   313 Q----------YRFLIYNTFVWCTAAIPTVVIF-SMNQMWENDPGKSE-----WLPLVGY----F 357
            |          ..||..:.|||  ..|..|::| .:..:.:....|.|     :|.::||    .
Zfish   476 QQVLCVVIAGLLHFLFLSAFVW--MFIEAVLLFICVKNLSQVSSRKKEVLSNGFLCVIGYVVALI 538

  Fly   358 GCSV------------KDW--NSSSWFYSHI-PIVILNSFNVIMFVLTAIYIWKVKKGVKSFAQH 407
            |.||            :.|  ....:|:|.: |:.::...|||:|:..:||:....|  |..|:.
Zfish   539 GVSVSIGMVPEGYGSEQCWIKMDKGFFWSFLGPVCVILGLNVILFISISIYLNSALK--KLNAEV 601

  Fly   408 DE-RNTTCLEFNVQTYIQFVRLFLIMGASWLLDQLTRLAEDSHLLLDTIVLNLTVYLNAAFGILI 471
            .: :.|..:.|  :|..|||    |:|..|:|.....        ::.:|..:.:.:|:..|..|
Zfish   602 SQLKQTKVMVF--KTLGQFV----ILGCPWILGFFAH--------VNMVVEIVFIIINSQQGTFI 652

  Fly   472 FVL 474
            |::
Zfish   653 FLI 655

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl12NP_731791.2 Methuselah_N 27..209 CDD:284145 23/104 (22%)
adgre10XP_021333746.1 GPS 360..406 CDD:197639 7/49 (14%)
7tm_GPCRs 413..672 CDD:333717 59/261 (23%)
TM helix 1 413..437 CDD:320095 5/23 (22%)
TM helix 2 446..467 CDD:320095 5/20 (25%)
TM helix 3 481..503 CDD:320095 6/23 (26%)
TM helix 4 527..543 CDD:320095 5/15 (33%)
TM helix 5 561..584 CDD:320095 6/22 (27%)
TM helix 6 608..631 CDD:320095 9/28 (32%)
TM helix 7 635..660 CDD:320095 5/21 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.