DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl12 and adgrl1a

DIOPT Version :9

Sequence 1:	NP_731791.2	Gene:	mthl12 / 261599	FlyBaseID:	FBgn0045442	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	XP_021330394.1	Gene:	adgrl1a / 562531	ZFINID:	ZDB-GENE-131127-267	Length:	1524	Species:	Danio rerio

Alignment Length:	287	Identity:	58/287 - (20%)
Similarity:	114/287 - (39%)	Gaps:	84/287 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 LSVISVVGFILT---LAVYLS-------VEKLRNLLGKCLICSLF---SMFM------EYFIWTM 265
            |.||:.||.:::   ||:.:|       ::..||.:.|.|..:||   .:|:      :|.|
Zfish   852 LFVITWVGIVISLVCLAICISTFCFLRGLQTDRNTIHKNLCINLFIAELLFLIGIDKTQYHI--- 913

  Fly   266 DYFRLLQSICSAAGYMKYFFSMSSYLWFSVVSFHLW----ELFTSLNRHEPQYRFLIYNTFVWCT 326
                    .|.....:.:||.::::.|..:....|:    |:|.| .....:|.:|       |.
Zfish   914 --------ACPIFAGLLHFFFLAAFSWMCLEGIQLYLMLVEVFES-EYSRKKYYYL-------CG 962

  Fly   327 AAIPTVVIFSMNQMWENDPG--KSEWLPLVGYFGCSVKDWNSSSWFYSHI-PIVILNSFNVIMFV 388
            ...|.:|:.....:.....|  |:.||.:..||            .:|.| |:..:...|::..:
Zfish   963 YCFPALVVGISAAIDYRSYGTKKACWLRVDNYF------------IWSFIGPVSFIIMLNLVFLM 1015

  Fly   389 LTAIYIWKVKKGVKSFAQHDERNTTCLE------FNVQTY-IQFVRLFLIMGASWLLDQLTRLAE 446
            :|      :.|.:        ||::.|:      .|:::: :..:.|..::|.:|... |..:.|
Zfish  1016 IT------LHKMI--------RNSSALKPDSSRLDNIKSWALGAIALLFLLGLTWAFG-LLFINE 1065

  Fly   447 DSHLLLDTIVLNLTVYLNAAFGILIFV 473
            ::     .|:..|....||..|:.||:
Zfish  1066 NT-----VIMAYLFTTFNAFQGMFIFI 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145
adgrl1a	XP_021330394.1	Gal_Lectin	48..128	CDD:307994
		OLF	142..398	CDD:321983
		HormR	474..535	CDD:214468
		GAIN	545..765	CDD:318649
		GPS	789..836	CDD:197639
		7tmB2_Latrophilin-1	849..1106	CDD:320673	58/287 (20%)
		TM helix 1	851..876	CDD:320673	8/23 (35%)
		TM helix 2	885..907	CDD:320673	6/21 (29%)
		TM helix 3	916..943	CDD:320673	4/26 (15%)
		TM helix 4	955..975	CDD:320673	5/26 (19%)
		TM helix 5	992..1021	CDD:320673	7/46 (15%)
		TM helix 6	1037..1064	CDD:320673	5/27 (19%)
		TM helix 7	1068..1093	CDD:320673	7/20 (35%)
		Latrophilin	1105..1524	CDD:308136
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810