Protein Alignment mthl12 and adgrl1a

DIOPT Version :10

• Sequence 1: NP_731791.2
• Gene: mthl12 / 261599
• FlyBaseID: FBgn0045442
• Length: 488
• Species: Drosophila melanogaster
• Sequence 2: XP_073801064.1
• Gene: adgrl1a / 562531
• ZFINID: ZDB-GENE-131127-267
• Length: 1524
• Species: Danio rerio
• Alignment Length: 287
• Identity: 58/287 - (20%)
• Similarity: 114/287 - (39%)
• Gaps: 84/287 - (29%)

  Fly   220 LSVISVVGFILT---LAVYLS-------VEKLRNLLGKCLICSLF---SMFM------EYFIWTM 265
            |.||:.||.:::   ||:.:|       ::..||.:.|.|..:||   .:|:      :|.|
Zfish   852 LFVITWVGIVISLVCLAICISTFCFLRGLQTDRNTIHKNLCINLFIAELLFLIGIDKTQYHI--- 913

  Fly   266 DYFRLLQSICSAAGYMKYFFSMSSYLWFSVVSFHLW----ELFTSLNRHEPQYRFLIYNTFVWCT 326
                    .|.....:.:||.::::.|..:....|:    |:|.| .....:|.:|       |.
Zfish   914 --------ACPIFAGLLHFFFLAAFSWMCLEGIQLYLMLVEVFES-EYSRKKYYYL-------CG 962

  Fly   327 AAIPTVVIFSMNQMWENDPG--KSEWLPLVGYFGCSVKDWNSSSWFYSHI-PIVILNSFNVIMFV 388
            ...|.:|:.....:.....|  |:.||.:..||            .:|.| |:..:...|::..:
Zfish   963 YCFPALVVGISAAIDYRSYGTKKACWLRVDNYF------------IWSFIGPVSFIIMLNLVFLM 1015

  Fly   389 LTAIYIWKVKKGVKSFAQHDERNTTCLE------FNVQTY-IQFVRLFLIMGASWLLDQLTRLAE 446
            :|      :.|.:        ||::.|:      .|:::: :..:.|..::|.:|... |..:.|
Zfish  1016 IT------LHKMI--------RNSSALKPDSSRLDNIKSWALGAIALLFLLGLTWAFG-LLFINE 1065

  Fly   447 DSHLLLDTIVLNLTVYLNAAFGILIFV 473
            ::     .|:..|....||..|:.||:
Zfish  1066 NT-----VIMAYLFTTFNAFQGMFIFI 1087

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:429053
		7tmB3_Methuselah-like	220..488	CDD:410632	58/287 (20%)
		TM helix 2	246..268	CDD:410632	7/30 (23%)
		TM helix 3	276..303	CDD:410632	4/30 (13%)
		TM helix 4	316..336	CDD:410632	4/19 (21%)
		TM helix 5	364..394	CDD:410632	5/30 (17%)
		TM helix 6	410..444	CDD:410632	8/40 (20%)
		TM helix 7	449..479	CDD:410632	7/25 (28%)
adgrl1a	XP_073801064.1	None