DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl12 and adgrg6

DIOPT Version :9

Sequence 1:NP_731791.2 Gene:mthl12 / 261599 FlyBaseID:FBgn0045442 Length:488 Species:Drosophila melanogaster
Sequence 2:NP_001356058.1 Gene:adgrg6 / 561970 ZFINID:ZDB-GENE-041014-357 Length:1208 Species:Danio rerio


Alignment Length:291 Identity:64/291 - (21%)
Similarity:111/291 - (38%) Gaps:75/291 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   184 SNDQYCL-----YPEIYSDFPETIRIINRRCYRNVMPGIAQLSV-ISVVGFILTLAVYLSVEKLR 242
            ||...||     :..|..|......:|:.:..| |:..|..:.. ||.:....||..|::.||||
Zfish   785 SNRTVCLCNHLTHFGILMDVSRAAELIDEKNNR-VLTFITYIGCGISAIFSAATLLTYIAFEKLR 848

  Fly   243 N------LLGKCLICSLFSMFMEYFI--WTMDYFRLLQSICSAAGYMKYFFSMSSYLWFSVVSFH 299
            .      |:.  |..||..:.|.:.:  |...|  .::.:|.......:||.::|:.|..:.|.|
Zfish   849 RDYPSKILMN--LSTSLLFLNMVFLLDGWLASY--EIKELCVTVAVFLHFFLLTSFTWMGLESIH 909

  Fly   300 LWELFTSLNRHEPQYRFLIYNTFV------WC-------TAAIPTVVIFSMNQMWENDPGKSE-- 349
            ::.....           ::||::      :|       .|.:..|:..|.:...:|..||.:  
Zfish   910 MYIALVK-----------VFNTYIRRYILKFCIVGWGVPAAIVGIVLAVSKDSYGKNYYGKGKDG 963

  Fly   350 -------WL--PLVGYFGCSVKDWNSSSWFYSHIPIVILNSFNVIMFVLTAIYIWKVKKGVKSFA 405
                   |:  |:|.|..|           .::..|:.|  .||.||::..|.|.. :.|.:|  
Zfish   964 QGTSEFCWILNPVVFYVTC-----------VAYFSIIFL--MNVAMFIVVMIQICG-RNGKRS-- 1012

  Fly   406 QHDERNTTCLEFNVQTYIQFVRLFLIMGASW 436
                 |.|..|..::.....|.|..::|.:|
Zfish  1013 -----NRTLREDILRNLRSVVSLTFLLGMTW 1038

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl12NP_731791.2 Methuselah_N 27..209 CDD:284145 7/29 (24%)
adgrg6NP_001356058.1 CUB 41..146 CDD:278839
LamG 153..336 CDD:354964
GPS 756..801 CDD:334696 4/15 (27%)
7tmB2_GPR126 816..1086 CDD:320662 57/260 (22%)
TM helix 1 818..843 CDD:320662 7/24 (29%)
TM helix 2 853..875 CDD:320662 5/23 (22%)
TM helix 3 886..913 CDD:320662 6/26 (23%)
TM helix 4 928..944 CDD:320662 2/15 (13%)
TM helix 5 975..998 CDD:320662 9/35 (26%)
TM helix 6 1021..1046 CDD:320662 4/18 (22%)
TM helix 7 1050..1075 CDD:320662
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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