DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl12 and adgrl3.1

DIOPT Version :9

Sequence 1:	NP_731791.2	Gene:	mthl12 / 261599	FlyBaseID:	FBgn0045442	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	XP_005170997.1	Gene:	adgrl3.1 / 560631	ZFINID:	ZDB-GENE-030131-7856	Length:	1540	Species:	Danio rerio

Alignment Length:	290	Identity:	65/290 - (22%)
Similarity:	116/290 - (40%)	Gaps:	68/290 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 LSVISVVGFILTLAVYL----------SVEKLRNLLGKCLICSLF---SMFMEYFIWTMDYFRLL 271
            |.||:.||.:|:|...|          .::..||.:.|.|..|||   ::|:      ....|..
Zfish   870 LDVITWVGILLSLVCLLICIFTFCFFRGLQSDRNTIHKNLCISLFIAETLFL------TGINRAD 928

  Fly   272 QSI-CSAAGYMKYFFSMSSYLWFSVVSFHLWELFTSLNRHEPQYRFLIYNTFVWCTAAIPTVVIF 335
            |.| |:....:.:||.::::.|..:....|:.:...:  .|.:|....|  |......:|.|::.
Zfish   929 QPIVCAVFAALLHFFFLAAFTWMFLEGVQLYIMLVEV--FESEYSRTKY--FYLTGYGVPAVIVA 989

  Fly   336 SMNQMWENDPGKSE--WLPLVGYFGCSVKDWNSSSWFYSHI-PIVILNSFNVIMFVLTAIYIWKV 397
            ....:.....|...  ||.|..||            .:|.| |..::...||| |:..|:|
Zfish   990 VSAAVDYRSYGTERVCWLRLDTYF------------IWSFIGPATLIIMLNVI-FLGIALY---- 1037

  Fly   398 KKGVKSFAQHD---ERNTTCLEFNVQTY-IQFVRLFLIMGASWLLDQLTRLAEDSHLLLDTIVLN 458
                |.| .|.   :.::.||: |:::: |..:.|..::|.:|... |..:.|.:     .|:..
Zfish  1038 ----KMF-HHTAILKPDSGCLD-NIKSWVIGAIALLCLLGLTWAFG-LMYINEST-----VIMAY 1090

  Fly   459 LTVYLNAAFGILIFVLLILKGSTFKMIMER 488
            |....|:..|:.||:        |..|:::
Zfish  1091 LFTIFNSLQGMFIFI--------FHCILQK 1112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145
adgrl3.1	XP_005170997.1	Gal_Lectin	66..146	CDD:280328
		OLF	160..415	CDD:128580
		HormR	493..553	CDD:214468
		GAIN	562..780	CDD:293098
		GPS	807..859	CDD:197639
		7tm_2	868..1103	CDD:278432	61/271 (23%)
		Latrophilin	1124..1540	CDD:280509
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910