DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl12 and Adgre4

DIOPT Version :10

Sequence 1:NP_731791.2 Gene:mthl12 / 261599 FlyBaseID:FBgn0045442 Length:488 Species:Drosophila melanogaster
Sequence 2:NP_631877.2 Gene:Adgre4 / 52614 MGIID:1196464 Length:689 Species:Mus musculus


Alignment Length:548 Identity:103/548 - (18%)
Similarity:193/548 - (35%) Gaps:161/548 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 INISHFKRLNDAYIYEHFEIPANLTG----------EFDYKE-----------------LMDGSK 70
            |||.|    .|.|:.:     :..||          ||..||                 |.:.|.
Mouse   119 INIDH----PDCYVNK-----SKNTGSKTHTLGVLSEFKSKEEVAKGATKLLRKVEHHILNENSD 174

  Fly    71 VPTEFPNLRGCICKVRPCIRIC-----CARKNILSNG------ECSDGVK-----NEIKLTML-- 117
            :|.:..|         |.:.|.     |....:|..|      :|:.|.|     .|..:..:  
Mouse   175 IPKKDEN---------PLLDIVYETKRCKTMTLLEAGNNTMKVDCTSGFKEHNSGGETAVAFIAY 230

  Fly   118 -------------------DLTMQDILLTDPTLAELNMIPQYNSTELLILREQFQPCDEIVSLKR 163
                               ::|:...:::....:|:..:   .|..:|:..:..||.|     .|
Mouse   231 KSLGNLLNGSFFSNEEGFQEVTLNSHIVSGAIRSEVKPV---LSEPVLLTLQNIQPID-----SR 287

  Fly   164 DEYTIL------KDGSILLHTSAEILSNDQY----CLYPEIYSDFPETIRIINRRCYRNVMPGI- 217
            .|:..:      :.||......:.:.:|:.|    |.:   .|.|...:.:.:..      .|: 
Mouse   288 AEHLCVHWEGSEEGGSWSTKGCSHVYTNNSYTICKCFH---LSSFAVLMALPHEE------DGVL 343

  Fly   218 AQLSVISVVGFILTL-------AVYLSVEKLRN----LLGKCLICSLFSMFMEYFIWTMDYFRLL 271
            :.||||:.||..|:|       ..:|....::|    |..:..||    :|:...::.....|..
Mouse   344 SALSVITYVGLSLSLLCLFLAAITFLLCRPIQNTSTTLHLQLSIC----LFLADLLFLTGINRTK 404

  Fly   272 QSI-CSAAGYMKYFFSMSSYLWFSVVSFHLWELFTSL------NRHEPQYRFLIYNTFVWCTAAI 329
            ..: ||....|.::..::|::|..:...||:...::|      |....:.||:....:     .:
Mouse   405 PKVLCSIIAGMLHYLYLASFMWMFLEGLHLFLTVSNLKVANYSNSGRFKKRFMYPVGY-----GL 464

  Fly   330 PTVVIFSMNQMWENDPGKSE--WLPL-VGYFGCSVKDWNSSSWFYSHIPIVILNSFNVIMFVLTA 391
            |..::.........:.|...  ||.| .|:.      |:    |......:||  .|::.:.|  
Mouse   465 PAFIVAVSAIAGHKNYGTHNHCWLSLHRGFI------WS----FLGPAAAIIL--INLVFYFL-- 515

  Fly   392 IYIWKVKKGVKSFAQHDERNTTCLEFNVQTYIQFVRLFLIMGASWLLDQLTRLAEDSHLLLDTIV 456
             .||.::..:.|.   ::..:|..:..|.|:...|:|| ::|.||.:.....:.....:.|  ||
Mouse   516 -IIWILRSKLSSL---NKEVSTLQDTKVMTFKAIVQLF-VLGCSWGIGLFIFIEVGKTVRL--IV 573

  Fly   457 LNLTVYLNAAFGILIFVLLILKGSTFKM 484
            ..|...:|...|:|||::..|.....:|
Mouse   574 AYLFTIINVLQGVLIFMVHCLLNRQVRM 601

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl12NP_731791.2 Methuselah_N 27..209 CDD:429053 41/249 (16%)
7tmB3_Methuselah-like 220..488 CDD:410632 61/286 (21%)
TM helix 2 246..268 CDD:410632 3/21 (14%)
TM helix 3 276..303 CDD:410632 6/26 (23%)
TM helix 4 316..336 CDD:410632 2/19 (11%)
TM helix 5 364..394 CDD:410632 6/29 (21%)
TM helix 6 410..444 CDD:410632 9/33 (27%)
TM helix 7 449..479 CDD:410632 10/29 (34%)
Adgre4NP_631877.2 EGF_CA 77..>105 CDD:214542
GAIN <214..264 CDD:465137 3/49 (6%)
GPS 290..332 CDD:460350 7/44 (16%)
GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098 292..339 7/49 (14%)
7tm_GPCRs 345..609 CDD:475119 61/287 (21%)
TM helix 1 346..370 CDD:410628 8/23 (35%)
TM helix 2 379..400 CDD:410628 4/24 (17%)
TM helix 3 410..432 CDD:410628 4/21 (19%)
TM helix 4 456..472 CDD:410628 2/20 (10%)
TM helix 5 491..514 CDD:410628 6/34 (18%)
TM helix 6 541..566 CDD:410628 7/25 (28%)
TM helix 7 571..596 CDD:410628 10/26 (38%)
Blue background indicates that the domain is not in the aligned region.

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