DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl12 and Adgre4

DIOPT Version :9

Sequence 1:	NP_731791.2	Gene:	mthl12 / 261599	FlyBaseID:	FBgn0045442	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_631877.2	Gene:	Adgre4 / 52614	MGIID:	1196464	Length:	689	Species:	Mus musculus

Alignment Length:	548	Identity:	103/548 - (18%)
Similarity:	193/548 - (35%)	Gaps:	161/548 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 INISHFKRLNDAYIYEHFEIPANLTG----------EFDYKE-----------------LMDGSK 70
            |||.|    .|.|:.:     :..||          ||..||                 |.:.|.
Mouse   119 INIDH----PDCYVNK-----SKNTGSKTHTLGVLSEFKSKEEVAKGATKLLRKVEHHILNENSD 174

  Fly    71 VPTEFPNLRGCICKVRPCIRIC-----CARKNILSNG------ECSDGVK-----NEIKLTML-- 117
            :|.:..|         |.:.|.     |....:|..|      :|:.|.|     .|..:..:
Mouse   175 IPKKDEN---------PLLDIVYETKRCKTMTLLEAGNNTMKVDCTSGFKEHNSGGETAVAFIAY 230

  Fly   118 -------------------DLTMQDILLTDPTLAELNMIPQYNSTELLILREQFQPCDEIVSLKR 163
                               ::|:...:::....:|:..:   .|..:|:..:..||.|     .|
Mouse   231 KSLGNLLNGSFFSNEEGFQEVTLNSHIVSGAIRSEVKPV---LSEPVLLTLQNIQPID-----SR 287

  Fly   164 DEYTIL------KDGSILLHTSAEILSNDQY----CLYPEIYSDFPETIRIINRRCYRNVMPGI- 217
            .|:..:      :.||......:.:.:|:.|    |.:   .|.|...:.:.:..      .|:
Mouse   288 AEHLCVHWEGSEEGGSWSTKGCSHVYTNNSYTICKCFH---LSSFAVLMALPHEE------DGVL 343

  Fly   218 AQLSVISVVGFILTL-------AVYLSVEKLRN----LLGKCLICSLFSMFMEYFIWTMDYFRLL 271
            :.||||:.||..|:|       ..:|....::|    |..:..||    :|:...::.....|..
Mouse   344 SALSVITYVGLSLSLLCLFLAAITFLLCRPIQNTSTTLHLQLSIC----LFLADLLFLTGINRTK 404

  Fly   272 QSI-CSAAGYMKYFFSMSSYLWFSVVSFHLWELFTSL------NRHEPQYRFLIYNTFVWCTAAI 329
            ..: ||....|.::..::|::|..:...||:...::|      |....:.||:....:     .:
Mouse   405 PKVLCSIIAGMLHYLYLASFMWMFLEGLHLFLTVSNLKVANYSNSGRFKKRFMYPVGY-----GL 464

  Fly   330 PTVVIFSMNQMWENDPGKSE--WLPL-VGYFGCSVKDWNSSSWFYSHIPIVILNSFNVIMFVLTA 391
            |..::.........:.|...  ||.| .|:.      |:    |......:||  .|::.:.|
Mouse   465 PAFIVAVSAIAGHKNYGTHNHCWLSLHRGFI------WS----FLGPAAAIIL--INLVFYFL-- 515

  Fly   392 IYIWKVKKGVKSFAQHDERNTTCLEFNVQTYIQFVRLFLIMGASWLLDQLTRLAEDSHLLLDTIV 456
             .||.::..:.|.   ::..:|..:..|.|:...|:|| ::|.||.:.....:.....:.|  ||
Mouse   516 -IIWILRSKLSSL---NKEVSTLQDTKVMTFKAIVQLF-VLGCSWGIGLFIFIEVGKTVRL--IV 573

  Fly   457 LNLTVYLNAAFGILIFVLLILKGSTFKM 484
            ..|...:|...|:|||::..|.....:|
Mouse   574 AYLFTIINVLQGVLIFMVHCLLNRQVRM 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145	41/249 (16%)
Adgre4	NP_631877.2	EGF_CA	77..>105	CDD:214542
		GAIN	<214..262	CDD:293098	3/47 (6%)
		GPS	290..332	CDD:280071	7/44 (16%)
		7tm_4	343..588	CDD:304433	56/274 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810