DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl12 and Adgrf2

DIOPT Version :9

Sequence 1:NP_731791.2 Gene:mthl12 / 261599 FlyBaseID:FBgn0045442 Length:488 Species:Drosophila melanogaster
Sequence 2:XP_017173054.1 Gene:Adgrf2 / 435529 MGIID:2182728 Length:673 Species:Mus musculus


Alignment Length:325 Identity:65/325 - (20%)
Similarity:127/325 - (39%) Gaps:92/325 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   189 CLYPEIYSDF-----PETIRIINRRCYRNVMPGIAQLSV-ISVVGFILTLAVYL---------SV 238
            |...::|:.|     |.|:.       ..|:..|..:.: ||:...|:.||:.:         .:
Mouse   358 CRPNKLYTSFSILMSPNTLE-------SPVLTYITYIGLGISICSLIICLAIEVLVWSQVTKTEI 415

  Fly   239 EKLRNLLGKCL--ICSLFSMFMEYFIWTMDYFR---LLQSICSAAGYMKYFFSMSSYLWF----S 294
            ..||:|   |:  |.:...|...:|| ...:..   |..:.|.||.:..:||.:|.:.|.    .
Mouse   416 SYLRHL---CIANIAATLLMADAWFI-VASFLSGPVLHHNGCVAATFFVHFFYLSVFFWMLAKAL 476

  Fly   295 VVSFHLWELFTSLNRHEPQYRFL--IYNTFVWC--TAAIPTVVIFSMNQMWENDPGKSEWLPLVG 355
            ::.:.:..:|.:|    |:...:  :::....|  ..||.|:.:        .:|||       |
Mouse   477 LILYGILIVFHTL----PKSCLVASLFSVGYGCPLVIAIITLAV--------TEPGK-------G 522

  Fly   356 YF---GCSVKDWNSS----SWFYSHIPIVILNSFNVIMFVLTAIYIWKVKKGVKSFAQHDERNTT 413
            |.   .|.: :|:.:    ::....:.||::|...|.|.::      |.::.....:...|    
Mouse   523 YLRPEACWL-NWDMTKALLAFVVPALAIVVVNLITVTMVII------KTQRAAIGSSMFQE---- 576

  Fly   414 CLEFNVQTYIQFVR----LFLIMGASWLLDQLTRLAEDSHLLLDTIVLNLTVYLNA--AFGILIF 472
                 |:..::..:    |..::|.:|.....|.:  :.|.|...|:.:|   |||  .|.||:|
Mouse   577 -----VRAIVRICKNIAILTPLLGLTWGFGIATVI--NGHSLAFHIIFSL---LNALQGFFILLF 631

  Fly   473  472
            Mouse   632  631

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl12NP_731791.2 Methuselah_N 27..209 CDD:284145 5/24 (21%)
Adgrf2XP_017173054.1 GPS 326..373 CDD:383024 3/14 (21%)
7tmB2_GPR111_115 378..644 CDD:320660 60/298 (20%)
TM helix 1 381..405 CDD:320660 6/23 (26%)
TM helix 2 420..441 CDD:320660 6/24 (25%)
TM helix 3 454..476 CDD:320660 6/21 (29%)
TM helix 4 497..513 CDD:320660 3/15 (20%)
TM helix 5 535..558 CDD:320660 3/22 (14%)
TM helix 6 581..606 CDD:320660 4/24 (17%)
TM helix 7 611..636 CDD:320660 10/24 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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