DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl12 and adgrl4

DIOPT Version :9

Sequence 1:NP_731791.2 Gene:mthl12 / 261599 FlyBaseID:FBgn0045442 Length:488 Species:Drosophila melanogaster
Sequence 2:NP_998532.2 Gene:adgrl4 / 406676 ZFINID:ZDB-GENE-040426-2689 Length:735 Species:Danio rerio


Alignment Length:286 Identity:69/286 - (24%)
Similarity:120/286 - (41%) Gaps:56/286 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   206 NRRCYRNVMPGIAQLS-VISVVGF---ILTLAVYLSVEKLRNLLGKCLICSLFSMFMEYFIWTMD 266
            |...:.||:..|.||. |||::..   |.|...:..::..|..:.|.|.|||   ||..||:.:.
Zfish   464 NLLAHYNVLTRITQLGMVISLICLSMCIFTFWFFRDIQNTRTTIHKNLCCSL---FMAQFIFLIG 525

  Fly   267 YFRLLQS-ICS-AAGYMKYFFSMSSYLWFSVVSFHLWELFTSLNRHEPQYRFLIYNTFVWCTAAI 329
            ..:.... .|| .||.:.||| ::::.|..:...||:.:...:..::   .||..|.:.:...:.
Zfish   526 INKSAHKWFCSLIAGLLHYFF-LAAFAWMCIEGIHLYLIVVGVIYNK---GFLHRNFYAFGYGSP 586

  Fly   330 PTVVIFSMNQMWENDPGKSEWLPLVGYFGCSVKDWNS--SSWFYSHI-PIVILNSFNVIMFVLTA 391
            ..||..|....::             |:|.|...|.|  :::.:|.| |.:::...|::.|   |
Zfish   587 AVVVAISATLGYK-------------YYGTSSVCWLSTENNFIWSFIGPAILIILVNLLAF---A 635

  Fly   392 IYIWKVKKGV---KSFAQHDERNTTCLEFNVQTYIQFVRLFLIMGASWLLDQLTRLAEDSHLLLD 453
            :.|:||.:..   |....|.|...:|..       ..:.|..::|.:|....:       ::|.:
Zfish   636 VIIYKVYRHTAVKKPEISHYENIRSCAR-------GAIALLFVLGVTWAFGVM-------YILYE 686

  Fly   454 TIVLNLTVYL----NAAFGILIFVLL 475
            |   .||.||    |...|:.||:.|
Zfish   687 T---TLTAYLFTFANVFQGMFIFIFL 709

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl12NP_731791.2 Methuselah_N 27..209 CDD:284145 1/2 (50%)
adgrl4NP_998532.2 EGF_CA 34..56 CDD:304395
EGF_CA 60..93 CDD:238011
EGF_CA 110..143 CDD:214542
GAIN 188..386 CDD:293098
GPS 416..457 CDD:280071
7tm_4 469..705 CDD:304433 65/275 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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