Protein Alignment mthl12 and mthl6

DIOPT Version :9

• Sequence 1: NP_731791.2
• Gene: mthl12 / 261599
• FlyBaseID: FBgn0045442
• Length: 488
• Species: Drosophila melanogaster
• Sequence 2: NP_788473.1
• Gene: mthl6 / 38839
• FlyBaseID: FBgn0035789
• Length: 480
• Species: Drosophila melanogaster
• Alignment Length: 487
• Identity: 185/487 - (37%)
• Similarity: 293/487 - (60%)
• Gaps: 23/487 - (4%)

  Fly     5 LKCFCTLIIVTIAKNSSAKIPHCKYDETINISHFKRLNDAYIYEHFEIPANLTGEFDYKELMDGS 69
            |.....:::..|:..|.|.||.|.|.:|::|||..:|||:|.||...|||:|||.:.:::|.|||
  Fly     3 LNILAIILVFVISSQSEAVIPGCDYFDTVDISHIPKLNDSYAYEELIIPAHLTGLYTFRQLADGS 67

  Fly    70 KVPTEFPNLRGCICKVRPCIRICCARKNILSNGECSDGVKNEIKL--TMLDLTMQDILLTDPTLA 132
            :.|.: .:||.||||::||||.||.|..::.|..||||:...:|.  ..|.:|::     |.|:.
  Fly    68 QEPVK-SHLRACICKLKPCIRFCCPRNKMMPNSRCSDGLTENLKRINPYLKITLE-----DGTIG 126

  Fly   133 ELNMIPQYNSTELLILREQFQPCDEIVSLKRDEYTILKDGSILLHTSAE-ILSNDQYCLYPEIYS 196
            :     .|..|::::||.:|:.|:::||::.|:|.:.::||.::..... .||...|||:|.:
  Fly   127 K-----YYLLTDMIVLRYEFRYCEKVVSVQEDQYKLYENGSFMIKPDVNWTLSKQWYCLHPRL-- 184

  Fly   197 DFPETIRIINRRCYRNVMPGIAQLSVISVVGFILTLAVYLSVEKLRNLLGKCLICSLFSMFMEYF 261
            :.|.:|.|:........||.:.|:..||:||.|||:||||.::|||||||||.||.:|..|::|.
  Fly   185 EDPNSIWILEHVYIPKSMPAVPQVGTISMVGCILTIAVYLYIKKLRNLLGKCFICYVFCKFVQYL 249

  Fly   262 IWTMDYFRLLQSICSAAGYMKYFFSMSSYLWFSVVSFHLWELFTSLNRHEPQYRFLIYNTFVWCT 326
            ||......|..:|||.|||..|||:::|:.|.||:|..:|:....:||.|..|.|||||.:.|.|
  Fly   250 IWAGGDLNLWNNICSLAGYTNYFFALASHFWLSVMSHQIWKNLRLINRDERSYHFLIYNIYGWGT 314

  Fly   327 AAIPTVVIFSMNQMWENDPGKSEWLPLVGYFGCSVKDWNSSSWFYSHIPIVILNSFNVIMFVLTA 391
            .||.|.:.:.::..||:.|.|..|:|.||.:.|.:..::.|:..|.:.|::||:.|||:.|:||.
  Fly   315 PAIMTAITYLVDWAWEDRPDKLNWIPGVGLYRCWINTYDWSAMIYLYGPMLILSLFNVVTFILTV 379

  Fly   392 IYIWKVKKGVKSFAQHDERNTTCLEFNVQTYIQFVRLFLIMGASWLLDQLTRLAEDSHLLLDTIV 456
            .:|.|:|..|||..|...:   |::.|  .::.::||.::||.:.:.:.:|...:.......  |
  Fly   380 NHIMKIKSSVKSSTQQQRK---CIQNN--DFLLYLRLSVMMGVTGISEVITYFVKRHKFWRQ--V 437

  Fly   457 LNLTVYLNAAFGILIFVLLILKGSTFKMIMER 488
            |.:..:.:...||::|||.|||.|||:|||||
  Fly   438 LRVPNFFHLGSGIVVFVLFILKRSTFQMIMER 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145	67/184 (36%)
mthl6	NP_788473.1	Mth_Ecto	25..197	CDD:119403	67/184 (36%)
		7tm_4	211..398	CDD:304433	84/186 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449110
Domainoid	1	1.000	49	1.000	Domainoid score	I4416
eggNOG	1	0.900	-	-		E1_KOG4193
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5395
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG25921
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	1	1.000	-	-		FOG0003851
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47154
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.910