Protein Alignment mthl12 and mthl2

DIOPT Version :10

• Sequence 1: NP_731791.2
• Gene: mthl12 / 261599
• FlyBaseID: FBgn0045442
• Length: 488
• Species: Drosophila melanogaster
• Sequence 2: NP_788462.2
• Gene: mthl2 / 38636
• FlyBaseID: FBgn0035623
• Length: 518
• Species: Drosophila melanogaster
• Alignment Length: 492
• Identity: 163/492 - (33%)
• Similarity: 274/492 - (55%)
• Gaps: 46/492 - (9%)

  Fly    18 KNSSAKIPHCKYDETINISHFKRL-NDAYIYEHFEIPANLTGEFDYKELMDGSK--VPTEFPNLR 79
            ::|||:|..|.:.:|::||..:|| |.:|:||...|||:||.::::|.|.:|.|  ||:   ::|
  Fly    22 QSSSAEIADCSFYDTVDISEGQRLSNGSYLYEGLLIPAHLTAKYEFKLLANGDKEQVPS---HVR 83

  Fly    80 GCICKVRPCIRICCARKNILSNGECSDGV---KNEIKLTMLDLTMQDILLTDPTLAELNMIPQYN 141
            ||:||:|.|:|.||...:|:..|||...:   :||:...||::|:.|          .:::.::.
  Fly    84 GCVCKLRTCVRFCCPHDHIMDMGECYANMTTEENELLDPMLNVTLDD----------GSVVQRHY 138

  Fly   142 STELLILREQFQPCDEIVSLKR----DEYTILKDGSILLHTSAEILSNDQYCLYPEIYSD-FPET 201
            ..||::..:..:|||::..|..    ||||:.::|.:|.|.....|...:|||....:.: ...:
  Fly   139 KKELMVQWDLPKPCDDMFYLDNRDIMDEYTLFENGRLLRHYDQVYLDKSEYCLQHRTFGEGNNNS 203

  Fly   202 IRIINRRCYRNVMP---GIAQLSVISVVGFILTLAVYLSVEKLRNLLGKCLICSLFSMFMEYFIW 263
            ||||...|.  ::|   |...:.:.|::..:||:||||.|:||.||.|||.||.:..:|..|...
  Fly   204 IRIIPHNCL--ILPSRTGQTVVMITSLICLVLTIAVYLCVKKLMNLEGKCFICYMMCLFFGYLFL 266

  Fly   264 TMDYFRLLQSICSAAGYMKYFFSMSSYLWFSVVSFHLWELFT----SLNRHEPQYRFLIYNTFVW 324
            .:|.:.|....|.|||::.|||.|:::.|.|::|.|.|:..|    |:|... :..||:|:.|.|
  Fly   267 LLDLWELSLDFCKAAGFLGYFFVMAAFFWLSIISRHYWKCLTNPCASMNIRS-ERAFLLYSCFAW 330

  Fly   325 CTAAIPTVVIFSMNQMWENDPGKSEWLPLVGYFG-CSV--KDWNSSSWFYSHIPIVILNSFNVIM 386
               |:| :.:..:..:.:|.....||.|.||..| |.:  |.|::..:||.  |:|:|..||:.|
  Fly   331 ---AMP-LALTGVTYLADNVVNNEEWQPRVGDEGHCWIYTKSWSAMVYFYG--PMVLLILFNITM 389

  Fly   387 FVLTAIYIWKVKKGVKSFAQHDERNTTCLEFNVQTYIQFVRLFLIMGASWLLDQLTRLAEDSHLL 451
            |||||.:|...|:.::..|:::.| ...|..:.|.|.||:.||.:||.||..:..:.|.:...|.
  Fly   390 FVLTAKHIIDSKRTLRKIARNEGR-IQKLNSDKQNYTQFLLLFTVMGMSWSFEIFSYLVQREKLW 453

  Fly   452 LDTIVLNLTVYLNAAFGILIFVLLILKGSTFKMIMER 488
            ::  :..:..|.|.:.|::||||.||:..|..:..::
  Fly   454 VN--IFLVADYFNWSQGVIIFVLFILRRKTLVLFKKQ 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:429053	62/192 (32%)
		7tmB3_Methuselah-like	220..488	CDD:410632	94/274 (34%)
		TM helix 2	246..268	CDD:410632	8/21 (38%)
		TM helix 3	276..303	CDD:410632	12/26 (46%)
		TM helix 4	316..336	CDD:410632	7/19 (37%)
		TM helix 5	364..394	CDD:410632	14/29 (48%)
		TM helix 6	410..444	CDD:410632	12/33 (36%)
		TM helix 7	449..479	CDD:410632	10/29 (34%)
mthl2	NP_788462.2	Methuselah_N	31..211	CDD:429053	62/192 (32%)
		7tmB3_Methuselah-like	215..489	CDD:410632	96/284 (34%)
		TM helix 1	215..240	CDD:410632	8/24 (33%)
		TM helix 2	249..269	CDD:410632	7/19 (37%)
		TM helix 3	279..306	CDD:410632	12/26 (46%)
		TM helix 4	322..342	CDD:410632	7/23 (30%)
		TM helix 5	367..397	CDD:410632	15/31 (48%)
		TM helix 6	419..446	CDD:410632	10/26 (38%)
		TM helix 7	454..479	CDD:410632	9/26 (35%)