DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl12 and mthl2

DIOPT Version :9

Sequence 1:	NP_731791.2	Gene:	mthl12 / 261599	FlyBaseID:	FBgn0045442	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_788462.2	Gene:	mthl2 / 38636	FlyBaseID:	FBgn0035623	Length:	518	Species:	Drosophila melanogaster

Alignment Length:	492	Identity:	163/492 - (33%)
Similarity:	274/492 - (55%)	Gaps:	46/492 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 KNSSAKIPHCKYDETINISHFKRL-NDAYIYEHFEIPANLTGEFDYKELMDGSK--VPTEFPNLR 79
            ::|||:|..|.:.:|::||..:|| |.:|:||...|||:||.::::|.|.:|.|  ||:   ::|
  Fly    22 QSSSAEIADCSFYDTVDISEGQRLSNGSYLYEGLLIPAHLTAKYEFKLLANGDKEQVPS---HVR 83

  Fly    80 GCICKVRPCIRICCARKNILSNGECSDGV---KNEIKLTMLDLTMQDILLTDPTLAELNMIPQYN 141
            ||:||:|.|:|.||...:|:..|||...:   :||:...||::|:.|          .:::.::.
  Fly    84 GCVCKLRTCVRFCCPHDHIMDMGECYANMTTEENELLDPMLNVTLDD----------GSVVQRHY 138

  Fly   142 STELLILREQFQPCDEIVSLKR----DEYTILKDGSILLHTSAEILSNDQYCLYPEIYSD-FPET 201
            ..||::..:..:|||::..|..    ||||:.::|.:|.|.....|...:|||....:.: ...:
  Fly   139 KKELMVQWDLPKPCDDMFYLDNRDIMDEYTLFENGRLLRHYDQVYLDKSEYCLQHRTFGEGNNNS 203

  Fly   202 IRIINRRCYRNVMP---GIAQLSVISVVGFILTLAVYLSVEKLRNLLGKCLICSLFSMFMEYFIW 263
            ||||...|.  ::|   |...:.:.|::..:||:||||.|:||.||.|||.||.:..:|..|...
  Fly   204 IRIIPHNCL--ILPSRTGQTVVMITSLICLVLTIAVYLCVKKLMNLEGKCFICYMMCLFFGYLFL 266

  Fly   264 TMDYFRLLQSICSAAGYMKYFFSMSSYLWFSVVSFHLWELFT----SLNRHEPQYRFLIYNTFVW 324
            .:|.:.|....|.|||::.|||.|:::.|.|::|.|.|:..|    |:|... :..||:|:.|.|
  Fly   267 LLDLWELSLDFCKAAGFLGYFFVMAAFFWLSIISRHYWKCLTNPCASMNIRS-ERAFLLYSCFAW 330

  Fly   325 CTAAIPTVVIFSMNQMWENDPGKSEWLPLVGYFG-CSV--KDWNSSSWFYSHIPIVILNSFNVIM 386
               |:| :.:..:..:.:|.....||.|.||..| |.:  |.|::..:||.  |:|:|..||:.|
  Fly   331 ---AMP-LALTGVTYLADNVVNNEEWQPRVGDEGHCWIYTKSWSAMVYFYG--PMVLLILFNITM 389

  Fly   387 FVLTAIYIWKVKKGVKSFAQHDERNTTCLEFNVQTYIQFVRLFLIMGASWLLDQLTRLAEDSHLL 451
            |||||.:|...|:.::..|:::.| ...|..:.|.|.||:.||.:||.||..:..:.|.:...|.
  Fly   390 FVLTAKHIIDSKRTLRKIARNEGR-IQKLNSDKQNYTQFLLLFTVMGMSWSFEIFSYLVQREKLW 453

  Fly   452 LDTIVLNLTVYLNAAFGILIFVLLILKGSTFKMIMER 488
            ::  :..:..|.|.:.|::||||.||:..|..:..::
  Fly   454 VN--IFLVADYFNWSQGVIIFVLFILRRKTLVLFKKQ 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145	62/192 (32%)
mthl2	NP_788462.2	Methuselah_N	31..211	CDD:284145	62/192 (32%)
mthl2	NP_788462.2	7tm_4	221..>395	CDD:304433	66/180 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I4416
eggNOG	1	0.900	-	-		E1_KOG4193
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5395
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG25921
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	1	1.000	-	-		FOG0003851
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47154
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.980