DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl12 and Adgrg5

DIOPT Version :9

Sequence 1:NP_731791.2 Gene:mthl12 / 261599 FlyBaseID:FBgn0045442 Length:488 Species:Drosophila melanogaster
Sequence 2:NP_001139444.1 Gene:Adgrg5 / 382045 MGIID:2685955 Length:524 Species:Mus musculus


Alignment Length:359 Identity:66/359 - (18%)
Similarity:125/359 - (34%) Gaps:140/359 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   192 PE-IYSDFPETIRII---NRRCYRNVM------PGIAQLSV-----------ISVVGFILTLAVY 235
            || .|::.|...:::   |...|..|:      |..|:|.|           ||:|..:||:.:|
Mouse   202 PEGCYTEQPSATQVLCHCNHLTYFAVLMQLSGDPVPAELQVPLEYISFVGCSISIVASLLTILLY 266

  Fly   236 LSVEKL--------RNLLGKCLICSL-FSMFMEYFIWTMDYFRLLQSICSAAGYMKYFFSMSSYL 291
            ....|.        .||.|..|:.:: |.:..:..:.||.     :.:|.....:.::..:||..
Mouse   267 AQSRKQSDSTTRIHMNLNGSVLLLNVTFLLSSQMTLPTMP-----RPVCKVLAAVLHYALLSSLT 326

  Fly   292 WFSVVSFHLWELFTSLNRHEPQYRFL--IYNTFV-----------WCTAAIPTVVIF-------- 335
            |.::..|:|             |.||  :||.::           |...|:..:::.        
Mouse   327 WMAIEGFNL-------------YLFLGRVYNAYIRRYLLKLCMLGWGFPALLVLLLLMIKSSVYG 378

  Fly   336 ----SMNQMWENDPGKSE----WL--PLV------GYFGCSVKDWNSSSWFYSHIPIVILNSFNV 384
                |:::..||..|...    |:  |:|      ||.|                   ..:.||:
Mouse   379 PCVTSLSKSQENGTGFQNVSMCWIRSPMVHSILVMGYGG-------------------FTSLFNL 424

  Fly   385 IMFVLTAIYIWKVKKGVKSFAQHDERNTTCLEFNVQTYIQFVRLFLIMGASW----------LLD 439
            ::.......:.:::...|:.:....|:|..:          :.|.:::|.:|          ||.
Mouse   425 VVLAWALWILCRLRAREKALSPWAYRDTAMV----------LGLTVLLGTTWTLAFFSFGVFLLP 479

  Fly   440 QLTRLAEDSHLLLDTIVLNLTVYLNAAFGILIFV 473
            |         |.|.||       .|:.:|..:|:
Mouse   480 Q---------LFLFTI-------FNSLYGFFLFL 497

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl12NP_731791.2 Methuselah_N 27..209 CDD:284145 5/20 (25%)
Adgrg5NP_001139444.1 GPS 184..228 CDD:366827 6/25 (24%)
7tm_GPCRs 242..514 CDD:391938 56/319 (18%)
TM helix 1 244..268 CDD:341315 6/23 (26%)
TM helix 2 277..298 CDD:341315 5/20 (25%)
TM helix 3 311..333 CDD:341315 3/21 (14%)
TM helix 4 353..369 CDD:341315 2/15 (13%)
TM helix 5 405..428 CDD:341315 7/41 (17%)
TM helix 6 449..474 CDD:341315 5/34 (15%)
TM helix 7 478..503 CDD:341315 9/36 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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