Protein Alignment mthl12 and mth

DIOPT Version :9

• Sequence 1: NP_731791.2
• Gene: mthl12 / 261599
• FlyBaseID: FBgn0045442
• Length: 488
• Species: Drosophila melanogaster
• Sequence 2: NP_728521.1
• Gene: mth / 38058
• FlyBaseID: FBgn0023000
• Length: 522
• Species: Drosophila melanogaster
• Alignment Length: 502
• Identity: 177/502 - (35%)
• Similarity: 288/502 - (57%)
• Gaps: 35/502 - (6%)

  Fly     3 LWLKCFCTLIIVTIAKNSSAKIPHCKYDETINISHFKRL-NDAYIYEHFEIPANLTGEFDYKELM 66
            |.|:....:::|.:.:.|.|.|..|.|.:|::||..::| |.:|::|...:||.||||:|::.|.
  Fly     5 LVLRISTVILVVLVIQKSYADILECDYFDTVDISAAQKLQNGSYLFEGLLVPAILTGEYDFRILP 69

  Fly    67 DGSKVPTEFPNLRGCICKVRPCIRICCARKNILSNGECSDGVKNEIKLTMLDLTMQDILLTDPTL 131
            |.||.... .::|||:||::||:|.||...:|:.||.|.|.:.:| :|..|| ...::.|.|.::
  Fly    70 DDSKQKVA-RHIRGCVCKLKPCVRFCCPHDHIMDNGVCYDNMSDE-ELAELD-PFLNVTLDDGSV 131

  Fly   132 AELNMIPQYNSTELLILREQFQPCDEIVSL----KRDEYTILKDGSILLHTSAEILSNDQYCLYP 192
            :.     ::...||::..:...|||.:..|    ::|:||:.::|:...|.....|...:|||..
  Fly   132 SR-----RHFKNELIVQWDLPMPCDGMFYLDNREEQDKYTLFENGTFFRHFDRVTLRKREYCLQH 191

  Fly   193 EIYSDFPET-IRIINRRCYRNVMPGIAQLSVI---SVVGFILTLAVYLSVEKLRNLLGKCLICSL 253
            ..::|...| |||....|.  ::|.|...:|:   |::..:||:||||.|:||:||.|||.||.:
  Fly   192 LTFADGNATSIRIAPHNCL--IVPSITGQTVVMISSLICMVLTIAVYLFVKKLQNLHGKCFICYM 254

  Fly   254 FSMFMEYFIWTMDYFRLLQSICSAAGYMKYFFSMSSYLWFSVVSFHLWELFT----SLNRHEPQY 314
            ..:||.|....:|.:::..|.|..||::.|||.|:::.|.||:|.|||..|.    ..||...::
  Fly   255 VCLFMGYLFLLLDLWQISISFCKPAGFLGYFFVMAAFFWLSVISLHLWNTFRGSSHKANRFLFEH 319

  Fly   315 RFLIYNTFVWCTAAIPTVVIFSMNQMWENDPGKSEWLPLVGYFG-CSV--KDWNSSSWFYSHIPI 376
            |||.|||:.|..|.:.|.:....:.:.||    .:|.|.||:.| |.:  :.|::..:||.  |:
  Fly   320 RFLAYNTYAWGMAVVLTGITVLADNIVEN----QDWNPRVGHEGHCWIYTQAWSAMLYFYG--PM 378

  Fly   377 VILNSFNVIMFVLTAIYIWKVKKGVKSFAQHDERNTTCLEFNVQTYIQFVRLFLIMGASWLLDQL 441
            |.|.:||:.||:|||..|..|||.:::||...||... |..:.|||..|:|||:|||.||.|:..
  Fly   379 VFLIAFNITMFILTAKRILGVKKDIQNFAHRQERKQK-LNSDKQTYTFFLRLFIIMGLSWSLEIG 442

  Fly   442 TRLAEDSHLLLDTIVLNLTVYLNAAFGILIFVLLILKGSTFKMIMER 488
            :..::.:....:  |..:..|||.:.||:||:|.:||.||::::.||
  Fly   443 SYFSQSNQTWAN--VFLVADYLNWSQGIIIFILFVLKRSTWRLLQER 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145	61/187 (33%)
mth	NP_728521.1	Methuselah_N	29..209	CDD:284145	61/187 (33%)
		7tm_4	219..416	CDD:304433	78/203 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I4416
eggNOG	1	0.900	-	-		E1_KOG4193
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5395
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG25921
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	1	1.000	-	-		FOG0003851
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47154
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.980