DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl12 and mthl3

DIOPT Version :9

Sequence 1:	NP_731791.2	Gene:	mthl12 / 261599	FlyBaseID:	FBgn0045442	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_001286526.1	Gene:	mthl3 / 36961	FlyBaseID:	FBgn0028956	Length:	511	Species:	Drosophila melanogaster

Alignment Length:	505	Identity:	170/505 - (33%)
Similarity:	274/505 - (54%)	Gaps:	55/505 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 TLIIVTIAKNSSAKIPHCKYDETINISHFKRL-NDAYIYEHFEIPANLTGEFDYKELMDGSKVPT 73
            |..::.:.:||:|:||.|.:.:|::||...|. |.:|:||...|||:||.|:|||.|.|.||...
  Fly     9 TAFLLLLLQNSNAEIPGCDFFDTVDISKAPRFSNGSYLYEGLLIPAHLTAEYDYKLLADDSKEKV 73

  Fly    74 EFPNLRGCICKVRPCIRICCARKNILSNGECSDGVKNEIKLTMLDLTMQDILLTDP----TLAEL 134
            . .::|||.|.:|||||.||.:...:...:|..           |::..::...||    ||::.
  Fly    74 A-SHVRGCACHLRPCIRFCCPQYQKMQKSKCYG-----------DMSEDELNKHDPFVNVTLSDG 126

  Fly   135 NMIPQYNSTELLILREQFQP-CDEIVSLKRD----EYTILKDGSILLHTSAEILSNDQYCLYPEI 194
            :::.::...:|::..:..:| |..:..|..:    |:|:.::||:|.|.....||..:||:....
  Fly   127 SVVRRHFKEDLIVQSDLAKPGCPRMYFLNHELPGNEFTLFENGSLLRHWDKVELSKREYCVQHLS 191

  Fly   195 YSDFPETIRIINRRC-----YRNVMPGIAQLSVISVVGFILTLAVYLSVEKLRNLLGKCLICSLF 254
            :.|  ::|||....|     :......:|  .|||::..|||::|||.|||||||.|||.||.|.
  Fly   192 FKD--DSIRIAPHFCPLSSEHSRTWKTVA--IVISLICIILTISVYLYVEKLRNLHGKCFICYLA 252

  Fly   255 SMFMEYFIWTMDYFRLLQSICSAAGYMKYFFSMSSYLWFSVVSFHLWELFTS----LNRHEPQYR 315
            |:|:.||...::.::.....|..||::.||..::::.|.||:|..||..|:.    |||..||.|
  Fly   253 SLFLGYFFLVLNVWKYSSGFCVTAGFLGYFSVIAAFFWLSVISLTLWNSFSGNSSWLNRFLPQNR 317

  Fly   316 FLIYNTFVWCTAAIPTVVIFSMNQMWENDP-------GKSEWLPLVGYFGCSVKDWNSSSWFYSH 373
            ||.||.:.|..|.:.|.:.:..:|:.:|:.       ||:.|:    |.|    |.....:||.
  Fly   318 FLSYNLYAWGMALLLTAITYIADQVVKNEKLRPRVGVGKNCWI----YTG----DMTVMIYFYG- 373

  Fly   374 IPIVILNSFNVIMFVLTAIYIWKVKKGVKSFAQHDERNTTCLEFNVQTYIQFVRLFLIMGASWLL 438
             |::::..||:.||||||..|.||||..::|.| .::.|..|..:.|||..|:|||:|||.||.|
  Fly   374 -PMLLIIVFNITMFVLTAFRIMKVKKEAQNFTQ-QQKTTNRLNSDKQTYALFLRLFIIMGLSWSL 436

  Fly   439 DQLTRLAEDSHLLLDTIVLNLTVYLNAAFGILIFVLLILKGSTFKMIMER 488
            :.::.|...:.......:  :..|.|.:.|.:||:|.:|:.||.|::.||
  Fly   437 EIISFLLSKNQAWAKAFM--VADYFNWSQGTVIFLLFVLRPSTLKLLKER 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145	57/191 (30%)
mthl3	NP_001286526.1	Methuselah_N	26..204	CDD:284145	57/191 (30%)
mthl3	NP_001286526.1	7tm_4	216..436	CDD:304433	92/232 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I4416
eggNOG	1	0.900	-	-		E1_KOG4193
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5395
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG25921
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	1	1.000	-	-		FOG0003851
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47154
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.980