Protein Alignment mthl12 and mthl4

DIOPT Version :10

• Sequence 1: NP_731791.2
• Gene: mthl12 / 261599
• FlyBaseID: FBgn0045442
• Length: 488
• Species: Drosophila melanogaster
• Sequence 2: NP_788394.1
• Gene: mthl4 / 36960
• FlyBaseID: FBgn0034219
• Length: 517
• Species: Drosophila melanogaster
• Alignment Length: 502
• Identity: 163/502 - (32%)
• Similarity: 265/502 - (52%)
• Gaps: 58/502 - (11%)

  Fly    12 IIVTIAKNSSAKIPHCKYDETINISHFKRL-NDAYIYEHFEIPANLTGEFDYKELMDGSKVPTEF 75
            ::..:...|:|:||.|.:.:|::||...|. |.:|:||...|||:||.|:|||.|.|.||....
  Fly     8 VLFLLMPKSNAEIPGCDFFDTVDISKAPRFSNGSYLYEGLLIPAHLTAEYDYKLLADDSKEKVA- 71

  Fly    76 PNLRGCICKVRPCIRICCARKNILSNGECSDGVKNEIKLTMLDLTMQDILLTDP----TLAELNM 136
            .::|||.|.:|||||.||.:...:...:|..           |::..::...||    ||::.::
  Fly    72 SHVRGCACHLRPCIRFCCPQYQKMQKSKCYG-----------DMSEDELNKHDPFVNVTLSDGSV 125

  Fly   137 IPQYNSTELLILREQFQP-CDEIVSLKRD----EYTILKDGSILLHTSAEILSNDQYCLYPEIYS 196
            :.::...:|::..:..:| |..:..|..:    |:|:.::||:|.|.....||..:||:....:.
  Fly   126 VRRHFKEDLIVQSDLAKPGCPRMYFLNHELPGNEFTLFENGSLLRHWDKVELSKREYCVQHLSFK 190

  Fly   197 DFPETIRIINRRC-----YRNVMPGIAQLSVISVVGFILTLAVYLSVEKLRNLLGKCLICSLFSM 256
            |  ::|||....|     :......:|  .|||::..|||::|||.|||||||.|||.||.|.|:
  Fly   191 D--DSIRIAPHFCPLSSEHSRTWKTVA--IVISLICIILTISVYLYVEKLRNLHGKCFICYLASL 251

  Fly   257 FMEYFIWTMDYFRLLQSICSAAGYMKYFFSMSSYLWFSVVSFHLWELFT----SLNRHEPQYRFL 317
            |:.||...::.::.....|..||::.||..|:::.|.||:..||...|:    .|:|..|:..|.
  Fly   252 FLGYFFLVLNVWKYSSGFCVTAGFLGYFSVMAAFFWLSVIGIHLRIKFSLASNCLHRLLPENPFR 316

  Fly   318 IYNTFVWCTAAIPTVVIFSMNQMWENDP-------GKSEWLPLVGYFGCSVKDWNSSSWFYSHIP 375
            .||.:.|....|.|.:.::.:|:.:|:.       ||:.|:    |.|    |.....:||.  |
  Fly   317 AYNLYAWGIPLIMTAITYTADQVVKNEKLRPRVGVGKNCWI----YTG----DMTVMIYFYG--P 371

  Fly   376 IVILNSFNVIMFVLTAIYIWKVKKGVKSFAQHDERNTTCLEFN-VQTYIQFVRLFLIMGASWLLD 439
            :::|.:||:|||||:||||:.:||.||......:.|.   :.| .|.:..|:|||::||.||..:
  Fly   372 MLLLIAFNIIMFVLSAIYIYNIKKNVKGLVHKQQTNQ---QINDQQMFAIFLRLFILMGLSWSFE 433

  Fly   440 QLTRLAEDSHLLLDTIVLNLTVYLNAAFGILIFVLLILKGSTFKMIM 486
            .|:.|..........::  :..|.|.:.|.:||||.|||.|..|:|:
  Fly   434 ILSFLLTKQQAWARALM--VADYFNWSQGTIIFVLFILKPSILKLII 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:429053	57/191 (30%)
		7tmB3_Methuselah-like	220..488	CDD:410632	100/279 (36%)
		TM helix 2	246..268	CDD:410632	10/21 (48%)
		TM helix 3	276..303	CDD:410632	10/26 (38%)
		TM helix 4	316..336	CDD:410632	6/19 (32%)
		TM helix 5	364..394	CDD:410632	13/29 (45%)
		TM helix 6	410..444	CDD:410632	12/34 (35%)
		TM helix 7	449..479	CDD:410632	9/29 (31%)
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:429053	57/191 (30%)
		7tmB3_Methuselah-like	205..477	CDD:410632	100/288 (35%)
		TM helix 1	207..232	CDD:410632	9/26 (35%)
		TM helix 2	241..263	CDD:410632	10/21 (48%)
		TM helix 3	271..298	CDD:410632	10/26 (38%)
		TM helix 4	315..335	CDD:410632	6/19 (32%)
		TM helix 5	361..390	CDD:410632	14/30 (47%)
		TM helix 6	411..438	CDD:410632	11/26 (42%)
		TM helix 7	446..471	CDD:410632	9/26 (35%)