DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl12 and Dh44-R2

DIOPT Version :10

Sequence 1:NP_731791.2 Gene:mthl12 / 261599 FlyBaseID:FBgn0045442 Length:488 Species:Drosophila melanogaster
Sequence 2:NP_610789.3 Gene:Dh44-R2 / 36368 FlyBaseID:FBgn0033744 Length:476 Species:Drosophila melanogaster


Alignment Length:400 Identity:77/400 - (19%)
Similarity:140/400 - (35%) Gaps:165/400 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   138 PQYNSTELLILREQFQPCDEIVSLKRDEYTILKDGSILLHTSAEILSNDQYCLYP----EIYSDF 198
            |:.|:..|.:|     ||.|  ..|...|....:.:             ::| :|    :.|||:
  Fly    95 PRTNAGSLAVL-----PCFE--EFKGVHYDTTDNAT-------------RFC-FPNGTWDHYSDY 138

  Fly   199 PETIRIINRRCYRN---------VMPGIAQLSVISVVGFILTLA-------VYLSVEKLRNLLGK 247
            .        ||::|         ..|.:...::|...|:.|:.|       ::||.:.||     
  Fly   139 D--------RCHQNSGSIPVVPDFSPNVELPAIIYAGGYFLSFATLVVALIIFLSFKDLR----- 190

  Fly   248 CLICSLF-SMFMEY----FIWTMDYF-RLLQSICSAAG-----YMKYFFSMSSYLWFSVVSFHLW 301
            ||..::. ::|:.|    .:|.:..| :::.:..|.||     .|..:|.::::.|..|...:|:
  Fly   191 CLRNTIHANLFLTYITSALLWILTLFLQVITTESSQAGCITLVIMFQYFYLTNFFWMFVEGLYLY 255

  Fly   302 EL----FTSLNRHEPQYRFLIYNTFVWCTAAIPTVVIFSMNQMWENDPGKSEWLPLVGYFGCSVK 362
            .|    |:|.|     ..|:||....|                                 ||   
  Fly   256 TLVVQTFSSDN-----ISFIIYALIGW---------------------------------GC--- 279

  Fly   363 DWNSSSWFYSHIPIVILNSFNVIMFVLTAIYIWKVKKGVKSFAQH-DERNTTCLEFNV----QTY 422
                        |.|             .|.:|.:   .|:||.| :..:...||.:.    :::
  Fly   280 ------------PAV-------------CILVWSI---AKAFAPHLENEHFNGLEIDCAWMRESH 316

  Fly   423 IQF-----------VRLFLIMGASWLLDQLTRLAEDSHLLLDTIVLNLTVYLNAAFGILIFVLLI 476
            |.:           |.|..::...|:|  :|:| ..:|      .|....|..|:..:|  ||:.
  Fly   317 IDWIFKVPASLALLVNLVFLIRIMWVL--ITKL-RSAH------TLETRQYYKASKALL--VLIP 370

  Fly   477 LKGSTFKMIM 486
            |.|.|:.:::
  Fly   371 LFGITYLLVL 380

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl12NP_731791.2 Methuselah_N 27..209 CDD:429053 14/74 (19%)
7tmB3_Methuselah-like 220..488 CDD:410632 59/304 (19%)
TM helix 2 246..268 CDD:410632 5/26 (19%)
TM helix 3 276..303 CDD:410632 8/31 (26%)
TM helix 4 316..336 CDD:410632 4/19 (21%)
TM helix 5 364..394 CDD:410632 3/29 (10%)
TM helix 6 410..444 CDD:410632 8/48 (17%)
TM helix 7 449..479 CDD:410632 8/29 (28%)
Dh44-R2NP_610789.3 HRM 82..144 CDD:397086 16/77 (21%)
7tmB1_DH_R 158..428 CDD:320391 59/307 (19%)
TM helix 1 160..185 CDD:320391 4/24 (17%)
TM helix 2 194..216 CDD:320391 3/21 (14%)
TM helix 3 230..257 CDD:320391 5/26 (19%)
TM helix 4 269..289 CDD:320391 10/80 (13%)
TM helix 5 314..343 CDD:320391 4/28 (14%)
TM helix 6 357..384 CDD:320391 8/25 (32%)
TM helix 7 390..415 CDD:320391
Blue background indicates that the domain is not in the aligned region.

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