DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl12 and Adgre5

DIOPT Version :9

Sequence 1:	NP_731791.2	Gene:	mthl12 / 261599	FlyBaseID:	FBgn0045442	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_001012164.1	Gene:	Adgre5 / 361383	RGDID:	1305595	Length:	825	Species:	Rattus norvegicus

Alignment Length:	317	Identity:	56/317 - (17%)
Similarity:	104/317 - (32%)	Gaps:	100/317 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 CYRNVMPGIA-----------QLSVISVVGFILTLAVYL----------SVEKLRNLLGKCLICS 252
            |:.|.:...|           :|.:|:.||.:|:|...|          .::..|.::...|...
  Rat   515 CHCNHLTSFAVLMAQYHVQDPRLELITKVGLLLSLVCLLLCILTFLLVKPIQSSRTMVHLHLCIC 579

  Fly   253 LFSMFMEYFIWTMDYFRLLQSICSAAGYMKYFFSMSSYLWFSVVSFHLWELFTSLNRHEPQYRFL 317
            ||...:.:.:...:....:...|.....:.:|..::::.|.::....|:              ||
  Rat   580 LFLGSVIFLVGVENEGGEVGLRCRLVAMLLHFCFLAAFCWMALEGVELY--------------FL 630

  Fly   318 IYNTFVWCTAAIPTVVIFSMNQMWENDPGKSEW-LPLVGY-----------------FGCSVKDW 364
            :...|                    ...|.|.| ..||||                 :|.:...|
  Rat   631 VVRVF--------------------QGQGLSTWHRCLVGYGVPLLIVAISAAARMDGYGHATYCW 675

  Fly   365 -----NSSSWFYSHIPIVILNSFNVIMFVLTAIYIWKVKKGVKSFAQHDERNTTCLEFNVQTYIQ 424
                 ....|.:|. |:..:...|..:||:|   :||:   .|.|::.:.......:..|.|...
  Rat   676 LDFRKQGFLWSFSG-PVAFIIFCNAAIFVIT---VWKL---TKKFSEINPNMKKLRKARVLTITA 733

  Fly   425 FVRLFLIMGASWLLDQLTRLAEDSHLLL----DTIVLNLTVYLNAAFGILIFVLLIL 477
            ..:| |::|.:|          ...|.|    .|.:..:...||...|:.::|.|.|
  Rat   734 IAQL-LVLGCTW----------GFGLFLFNPHSTWLSYIFTLLNCLQGLFLYVTLCL 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145	56/317 (18%)
Adgre5	NP_001012164.1	EGF_CA	69..>101	CDD:214542
		EGF_CA	171..218	CDD:284955
		EGF_CA	220..265	CDD:284955
		GPS	487..526	CDD:280071	3/10 (30%)
		7tm_2	534..773	CDD:278432	50/290 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810