DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl12 and Cirl

DIOPT Version :9

Sequence 1:	NP_731791.2	Gene:	mthl12 / 261599	FlyBaseID:	FBgn0045442	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster

Alignment Length:	382	Identity:	77/382 - (20%)
Similarity:	137/382 - (35%)	Gaps:	114/382 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 ELNMIPQYNSTELLILREQFQPCDEIVSLKR---DEYTILKDGSILLHTSAEILSNDQYCLYPEI 194
            ||......:::|..::|..|...|.:.|:.:   |.:.:....|.:.:|:  |||||......||
  Fly   602 ELPRAALIDNSEGGLVRIVFAAFDRLESILKPSYDHFDLKSSRSYVRNTA--ILSNDSDVNAGEI 664

  Fly   195 YSDFPETIRIINRRCY-------RNVMPGIAQLSVISVVGFILTLAVYLSVEKLRNLLGKCLICS 252
                .:.:||:|.:..       |::     |||    ....|||. :|..|.:.|  ..|
  Fly   665 ----QQRLRILNSKVISASLGKGRHI-----QLS----QPITLTLK-HLKTENVTN--PTC---- 709

  Fly   253 LFSMFMEYF--IW-----TMDYFRLLQSICSAAGYMKYFFSMSSYLWFSVVSFHLWELFTSLNRH 310
               :|..|.  .|     :::......|:||......:...|      .||..|...|||..
  Fly   710 ---VFWNYIDHAWSANGCSLESTNRTHSVCSCNHLTNFAILM------DVVDEHQHSLFTMF--- 762

  Fly   311 EPQYRFLIYNTF----VWCTAAIPTVVIFSMNQMWENDPGKSEWLPLVGYFGCSVKDWNSSSWFY 371
            :...|..||.:.    |:...|:.|:.:|:                     |..||...:|  .|
  Fly   763 DGNMRIFIYISIGICVVFIVIALLTLKLFN---------------------GVFVKSARTS--IY 804

  Fly   372 SHIPIVILNSFNVIMFVLTAIYIWKVKKGVKSFAQHDERNTTCLEFNVQTYIQFVRLFL----IM 432
            :.|.:.:|..  .::|:|          |:       |:..|.:      :..|:.:||    :.
  Fly   805 TSIYLCLLAI--ELLFLL----------GI-------EQTETSI------FCGFITIFLHCAILS 844

  Fly   433 GASWL----LDQLTRLAEDSHLLLDTIVLNLTVYLNAAFGI---LIFVLLILKGSTF 482
            |.:|.    ....:.|..|..||.......:..|...::|:   ::.:.|::..||:
  Fly   845 GTAWFCYEAFHSYSTLTSDELLLEVDQTPKVNCYYLLSYGLSLSVVAISLVIDPSTY 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145	20/78 (26%)
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	20/83 (24%)
		GPS	705..752	CDD:197639	10/61 (16%)
		7tm_4	763..1014	CDD:304433	33/187 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462224
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830