DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl12 and ADGRD2

DIOPT Version :9

Sequence 1:	NP_731791.2	Gene:	mthl12 / 261599	FlyBaseID:	FBgn0045442	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_001382354.1	Gene:	ADGRD2 / 347088	HGNCID:	18651	Length:	982	Species:	Homo sapiens

Alignment Length:	293	Identity:	60/293 - (20%)
Similarity:	107/293 - (36%)	Gaps:	60/293 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 LSVISVVG-----------FILTLAVYLSVEKLRNLLGKCLICSLFSMFMEYFIWTMDYFRLLQS 273
            |..:|.||           |:|.|...:...: |..:.|.|..||.|  .|.|:.|.::.:..:.
Human   695 LRTLSFVGCGVSFCALTTTFLLFLVAGVPKSE-RTTVHKNLTFSLAS--AEGFLMTSEWAKANEV 756

  Fly   274 ICSAAGYMKYFFSMSSYLWFSVVSFHLWELFTSLNRHEPQYRFLIYNTFVWCTAAIPTVVIFSMN 338
            .|.|.....:|..:.::.|..|....||....:::.| |.....:|:...|   .:|..::....
Human   757 ACVAVTVAMHFLFLVAFSWMLVEGLLLWRKVVAVSMH-PGPGMRLYHATGW---GVPVGIVAVTL 817

  Fly   339 QMWEND---PGKSEWLPLVGYFGCSVKDWNSSSWFYSHIPIVILNSFNVIMFVLTA--IYIWKVK 398
            .|..:|   ||.           |.:....::.|.:          ...::|||||  ..:.:|.
Human   818 AMLPHDYVAPGH-----------CWLNVHTNAIWAF----------VGPVLFVLTANTCILARVV 861

  Fly   399 KGVKSFAQHDERNTT---CLEFNVQTYI-----QFVRLFLIMGASWLLDQLTRLAEDSHLLLDTI 455
            ....|.|:...|..:   ||:..:.|.|     ..:.|..::|.:||...|..|:        ..
Human   862 MITVSSARRRARMLSPQPCLQQQIWTQIWATVKPVLVLLPVLGLTWLAGILVHLS--------PA 918

  Fly   456 VLNLTVYLNAAFGILIFVLLILKGSTFKMIMER 488
            .....|.||:..|:.||::........:..::|
Human   919 WAYAAVGLNSIQGLYIFLVYAACNEEVRSALQR 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145
ADGRD2	NP_001382354.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810