DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl12 and Adgrl1

DIOPT Version :9

Sequence 1:NP_731791.2 Gene:mthl12 / 261599 FlyBaseID:FBgn0045442 Length:488 Species:Drosophila melanogaster
Sequence 2:XP_030099484.1 Gene:Adgrl1 / 330814 MGIID:1929461 Length:1543 Species:Mus musculus


Alignment Length:403 Identity:83/403 - (20%)
Similarity:161/403 - (39%) Gaps:87/403 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   102 GECSDG--------VKNEIKLTMLDLTMQDILLTDP---TLAELNMIPQYN--------STELLI 147
            ||...|        |.:::....::.....:.|.||   |:|.|.....:|        |...::
Mouse   820 GEAGTGGPGGASLVVNSQVIAASINKESSRVFLMDPVIFTVAHLEAKNHFNANCSFWNYSERSML 884

  Fly   148 LREQFQPCDEIVSLKRDEYTILKDGSILLHTSAEILSNDQYCLYPEIYSDFPETIRIINRRCYRN 212
            .....|.|..:.|.|             .||:..       |.:   .::|  .:.:.:|..|:.
Mouse   885 GYWSTQGCRLVESNK-------------THTTCA-------CSH---LTNF--AVLMAHREIYQG 924

  Fly   213 VMPGIAQLSVISVVGFILT---LAVYLS-------VEKLRNLLGKCLICSLFSMFMEYFIWTMDY 267
            .:..:. ||||:.||.:::   ||:.:|       ::..||.:.|.|..:||...: .|:..:|.
Mouse   925 RINELL-LSVITWVGIVISLVCLAICISTFCFLRGLQTDRNTIHKNLCINLFLAEL-LFLVGIDK 987

  Fly   268 FRLLQSICSAAGYMKYFFSMSSYLWFSVVSFHLWELFTSLNRHEPQY-RFLIYNTFVWCTAAIPT 331
            .:...:....||.:.||| ::::.|..:...||:.|...:  .|.:| |...|....:|..|: .
Mouse   988 TQYEVACPIFAGLLHYFF-LAAFSWLCLEGVHLYLLLVEV--FESEYSRTKYYYLGGYCFPAL-V 1048

  Fly   332 VVIFSMNQMWENDPGKSEWLPLVGYFGCSVKDWNSSSWFYSHIPIVILNSFNVIMFVLTAIYIWK 396
            |.|.:..........|:.||.:..||     .|:    |...:..||:  .|::..::|      
Mouse  1049 VGIAAAIDYRSYGTEKACWLRVDNYF-----IWS----FIGPVSFVIV--VNLVFLMVT------ 1096

  Fly   397 VKKGVKSFAQHDERNTTCLEFNVQTY-IQFVRLFLIMGASWLLDQLTRLAEDSHLLLDTIVLNLT 460
            :.|.::| :...:.:::.|: |:::: :..:.|..::|.:|....|....|      ..::..|.
Mouse  1097 LHKMIRS-SSVLKPDSSRLD-NIKSWALGAIALLFLLGLTWAFGLLFINKE------SVVMAYLF 1153

  Fly   461 VYLNAAFGILIFV 473
            ...||..|:.|||
Mouse  1154 TTFNAFQGVFIFV 1166

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl12NP_731791.2 Methuselah_N 27..209 CDD:284145 21/125 (17%)
Adgrl1XP_030099484.1 OLF 214..470 CDD:383019
PLN02550 491..>573 CDD:178165
HormR 548..611 CDD:214468
GAIN 621..845 CDD:374574 4/24 (17%)
GPS 869..921 CDD:197639 11/76 (14%)
7tmB2_Latrophilin-1 928..1185 CDD:320673 61/270 (23%)
TM helix 1 931..955 CDD:320673 9/23 (39%)
TM helix 2 964..985 CDD:320673 6/21 (29%)
TM helix 3 995..1017 CDD:320673 6/22 (27%)
TM helix 4 1036..1052 CDD:320673 4/16 (25%)
TM helix 5 1071..1094 CDD:320673 7/33 (21%)
TM helix 6 1118..1143 CDD:320673 4/24 (17%)
TM helix 7 1147..1172 CDD:320673 7/20 (35%)
Latrophilin 1185..1543 CDD:367050
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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