Protein Alignment mthl12 and mthl1

DIOPT Version :9

• Sequence 1: NP_731791.2
• Gene: mthl12 / 261599
• FlyBaseID: FBgn0045442
• Length: 488
• Species: Drosophila melanogaster
• Sequence 2: NP_001285340.1
• Gene: mthl1 / 32637
• FlyBaseID: FBgn0030766
• Length: 676
• Species: Drosophila melanogaster
• Alignment Length: 542
• Identity: 112/542 - (20%)
• Similarity: 190/542 - (35%)
• Gaps: 162/542 - (29%)

  Fly    25 PHCKYDETINISHFKRLN-------DAYIYEH------------FEI---------PANLTGEFD 61
            |.|:.|:|..|...:..|       ..|:.|.            :|:         |.|...:.|
  Fly   113 PTCRKDQTTEIFRSRGANVMLFPNGTLYVRERALMVQPSDYCVDWEVAVVCLNDSQPINALEDPD 177

  Fly    62 YKELMDGSKVPTEFPNLRGCICKVRPCIRI--CCARKNILSNGECSDGVKNEIKLTMLDL----- 119
            |..   ...|..|.|         :..:|:  ||.:.     |..:..::|      .||
  Fly   178 YAA---NPLVQQEPP---------KASLRLSKCCGKW-----GSYNTQLQN------CDLQPNHQ 219

  Fly   120 -TMQDILLTDPTLAELNMIPQYNSTELLILREQFQPCDEIVSLKRDEYTILKD--------GSIL 175
             .:..:|...|.|.|.:....|.      |.:..||         ..|:|..|        .:.:
  Fly   220 AAVDGLLRLSPQLPEGSYQTSYG------LPDCGQP---------GGYSIAGDWQDAKLDRNTAM 269

  Fly   176 LHTSAEILSNDQYCLYPEIYSDFPETIRII---------------------------NRRCYRNV 213
            |....:.||..||||.   ::.....::||                           .:...:.|
  Fly   270 LQLPHKNLSAGQYCLE---HTQREGEVKIIACQHLFSSAAGAGIHDGSIGGTIEQANGQNLQKAV 331

  Fly   214 MPG-----IAQLSVISVVGFILTLAVYLSVEKLRNLLGKCLICSLFSMFMEYFIWTMDYFRLLQS 273
            :.|     |..||...|.||:|. ||:      ..|..:|.||.:..:.....:..::  .|..|
  Fly   332 LTGGILVSIVFLSATLVAGFLLP-AVH------HALHWRCQICYVTCLLFGKILLAIE--ELSSS 387

  Fly   274 I------CSAAGYMKYFFSMSSYLWFSVVSFHLWELF-----TSLNRHEPQYRFLIYNTFVWCTA 327
            :      |........||.::::.|.:.:.|::|..|     :||.|::...|..:|:.:.|...
  Fly   388 LQPGSAACHTLAITMQFFFLAAFFWLNTMCFNIWWTFRDFRPSSLERNQEALRRYLYSLYAWGGP 452

  Fly   328 AIPTVVIFSMNQMWENDPGKSEWLPLVGYFGCSVKDWNSSSWFYSHIPIVILNSFNVIMFVLT-- 390
            .:.|.|...::|:    |..:...|..|...|...:.|.|.:.|.:.||.:|...|:.:||.|
  Fly   453 LLITFVAACVDQL----PETTLLRPGFGQLYCWFDNRNLSIFAYFYGPIGLLLCANIALFVSTTH 513

  Fly   391 --AIYIWKVKKGVKSFAQHDERNTTCLEFNVQTYIQFVRLFLIMGASWLLDQLTRLAEDSHLLLD 453
              ...:|| :..|||.::.......||           :|.::||.:|:.|.|:.|....|
  Fly   514 QLTCGLWK-RDDVKSSSEKSALGRVCL-----------KLVVVMGVTWIADILSWLVGGPH---- 562

  Fly   454 TIVLNLTVYLNAAFGILIFVLL 475
             .|...|..:||..|:.||:::
  Fly   563 -GVWFFTDLINALQGVFIFIVV 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145	42/252 (17%)
mthl1	NP_001285340.1	7tm_4	329..579	CDD:304433	67/279 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462210
Domainoid	1	1.000	49	1.000	Domainoid score	I4416
eggNOG	1	0.900	-	-		E1_KOG4193
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.750