Protein Alignment mthl12 and adgrg1

DIOPT Version :10

• Sequence 1: NP_731791.2
• Gene: mthl12 / 261599
• FlyBaseID: FBgn0045442
• Length: 488
• Species: Drosophila melanogaster
• Sequence 2: NP_001018317.1
• Gene: adgrg1 / 324948
• ZFINID: ZDB-GENE-030131-3671
• Length: 648
• Species: Danio rerio
• Alignment Length: 331
• Identity: 57/331 - (17%)
• Similarity: 115/331 - (34%)
• Gaps: 104/331 - (31%)

  Fly    56 LTGEFDYKELMDGSKVPTEFPNLRGCICKVRPC--IRICCARKNILSNGECSDGVKNEIKL---- 114
            :||:.....:.||:.:.          ||.:.|  .|:.....|::.........|..:.|
Zfish   154 ITGDLKGNYIFDGAHIN----------CKEKFCDEARLKPRGANMIEEVVMRFNAKGRVDLPCAQ 208

  Fly   115 -TMLDL----TMQDILLTDPTLAELNMIPQ--------------------YNSTELLILREQFQP 154
             |::::    |..:..:..|...:.|.||.                    |...:.|..|...:.
Zfish   209 GTVIEMDEEFTGHNFTVPAPRFVDANTIPSVYIPSSLRSVSRRKSKVVCTYYKNKTLFERGPSKS 273

  Fly   155 C--DEIVSLKRDEYTI---LKDGSILLH-------TSAEILS-----------NDQYCLYPEIYS 196
            .  |:||.|..:..||   ::...|..|       :|...:|           .|..|
Zfish   274 ALLDDIVGLSVENETIRNLIEPVKIRFHHRPFAPDSSGRCVSWDTKQDNEVNWKDDGC------- 331

  Fly   197 DFPETIRI--------INRRCYRNVMPGIAQ---------LSVISVVGFILTLA-----VYLSVE 239
               :|::|        .|...|..::..:.|         |:.|:.||..::|.     .|...:
Zfish   332 ---DTVKINEEQTECHCNHLTYFAILVQVEQKSTVRHLKALTFITAVGCAVSLVSCLVLFYWLCK 393

  Fly   240 KLR------NLLGKCLICSLFSMFMEYFIWTMDYFRLL-QSICSAAGYMKYFFSMSSYLWFSVVS 297
            :.|      :|:.:.|:.::|.:.: :||.|.....:. :::|...|.:.::..:|:..|.::..
Zfish   394 RRRGKKNQISLVHRGLVVAIFLLCL-FFILTGILANVANETVCQLTGSLLHYGLLSTLCWMAMEV 457

  Fly   298 FHLWEL 303
            ||.:.|
Zfish   458 FHTFLL 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:429053	35/214 (16%)
		7tmB3_Methuselah-like	220..488	CDD:410632	20/96 (21%)
		TM helix 2	246..268	CDD:410632	5/21 (24%)
		TM helix 3	276..303	CDD:410632	5/26 (19%)
		TM helix 4	316..336	CDD:410632
		TM helix 5	364..394	CDD:410632
		TM helix 6	410..444	CDD:410632
		TM helix 7	449..479	CDD:410632
adgrg1	NP_001018317.1	GPS	312..354	CDD:460350	7/51 (14%)
		GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098	313..361		8/57 (14%)
		Stachel. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098	349..361		2/11 (18%)
		7tm_GPCRs	366..620	CDD:475119	20/99 (20%)
		TM helix 1	369..393	CDD:410628	6/23 (26%)
		TM helix 2	403..424	CDD:410628	5/21 (24%)
		TM helix 3	436..458	CDD:410628	3/21 (14%)
		TM helix 4	478..492	CDD:410628
		TM helix 5	526..549	CDD:410628
		TM helix 6	568..590	CDD:410628
		TM helix 7	594..619	CDD:410628