DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl12 and Adgrl3

DIOPT Version :9

Sequence 1:NP_731791.2 Gene:mthl12 / 261599 FlyBaseID:FBgn0045442 Length:488 Species:Drosophila melanogaster
Sequence 2:XP_011247763.1 Gene:Adgrl3 / 319387 MGIID:2441950 Length:1586 Species:Mus musculus


Alignment Length:273 Identity:61/273 - (22%)
Similarity:103/273 - (37%) Gaps:47/273 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   220 LSVISVVGFILTLAVYL----------SVEKLRNLLGKCLICSLFSMFMEYFIWTMDYFRLLQSI 274
            |.||:.||.:|:|...|          .::..||.:.|.|..||   |:...::.:...|..|.|
Mouse   945 LDVITWVGILLSLVCLLICIFTFCFFRGLQSDRNTIHKNLCISL---FVAELLFLIGINRTDQPI 1006

  Fly   275 -CSAAGYMKYFFSMSSYLWFSVVSFHLWELFTSLNRHEPQYRFLIYNTFVWCTAAIPTVVIFSMN 338
             |:....:.:||.::::.|..:....|:.:...:...|...|...|.......|.|..|......
Mouse  1007 ACAVFAALLHFFFLAAFTWMFLEGVQLYIMLVEVFESEHSRRKYFYLVGYGMPALIVAVSAAVDY 1071

  Fly   339 QMWENDPGKSEWLPLVGYFGCSVKDWNSSSWFYSHI-PIVILNSFNVIMFVLTAIY-------IW 395
            :.:..|  |..||.|..||            .:|.| |..::...||| |:..|:|       |.
Mouse  1072 RSYGTD--KVCWLRLDTYF------------IWSFIGPATLIIMLNVI-FLGIALYKMFHHTAIL 1121

  Fly   396 KVKKGVKSFAQHDERNTTCLEFNVQTYIQFVRLFLIMGASWLLDQLTRLAEDSHLLLDTIVLNLT 460
            |.:.|......:::..    .|.....|..:.|..::|.:|... |..:.|.:     .|:..|.
Mouse  1122 KPESGCLDNINYEDNR----PFIKSWVIGAIALLCLLGLTWAFG-LMYINEST-----VIMAYLF 1176

  Fly   461 VYLNAAFGILIFV 473
            ...|:..|:.||:
Mouse  1177 TIFNSLQGMFIFI 1189

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl12NP_731791.2 Methuselah_N 27..209 CDD:284145
Adgrl3XP_011247763.1 Gal_Lectin 111..191 CDD:366935
OLF 205..461 CDD:128580
HormR 563..627 CDD:214468
GAIN 636..856 CDD:374574
GPS 882..934 CDD:197639
7tmB2_Latrophilin-3 942..1208 CDD:320671 61/273 (22%)
TM helix 1 945..969 CDD:320671 8/23 (35%)
TM helix 2 978..999 CDD:320671 6/23 (26%)
TM helix 3 1009..1031 CDD:320671 3/21 (14%)
TM helix 4 1050..1066 CDD:320671 3/15 (20%)
TM helix 5 1085..1108 CDD:320671 9/35 (26%)
TM helix 6 1141..1166 CDD:320671 5/25 (20%)
TM helix 7 1170..1195 CDD:320671 6/20 (30%)
Latrophilin 1208..1586 CDD:367050
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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