Protein Alignment mthl12 and mthl15

DIOPT Version :9

• Sequence 1: NP_731791.2
• Gene: mthl12 / 261599
• FlyBaseID: FBgn0045442
• Length: 488
• Species: Drosophila melanogaster
• Sequence 2: NP_723538.3
• Gene: mthl15 / 318914
• FlyBaseID: FBgn0051720
• Length: 718
• Species: Drosophila melanogaster
• Alignment Length: 583
• Identity: 135/583 - (23%)
• Similarity: 235/583 - (40%)
• Gaps: 166/583 - (28%)

  Fly     6 KCFCTLIIVTIAKNSSAK--------------IPHCKYDETINISHFKRL-------------ND 43
            || |....:.:::|::.|              .|...:|.|:|.|..:.|             |:
  Fly   143 KC-CPQGFIYVSENNTCKPGESDFFVYTSIISSPIIFFDNTLNCSDHRALVEYTLSSGKVHFHNN 206

  Fly    44 AYIYEH--FEIPANLTGEFDYKEL-------MDGSKVPTEFPNLRGC----ICKVRPCIRICCAR 95
            :.|::.  ..:|::   :|..:.:       :|...:|.:...:|.|    ||:..||||.|||.
  Fly   207 SLIWKDGTNSLPSS---KFCIEAIHDSDDADLDRGALPEQKFLVRACQEMKICQKIPCIRRCCAE 268

  Fly    96 KNILSNGECSDGVKNEIKLTMLDLTMQDILLTDPTLAELNMIPQYNSTELLILREQFQPCD-EIV 159
            ..:.:.|..|    ...|:...|...:.       ...||:...::           :|.| .||
  Fly   269 GEMYAKGNFS----TYCKIDGTDFKFEG-------FQNLNINANFS-----------KPSDFGIV 311

  Fly   160 -------------SLKRDEYTI-LKDGSILLHTSAEILSNDQYCLYPEIYSDFPETIR----IIN 206
                         :...|.:|| ..:||:::|.:.:..:|.|||:         |.:|    :..
  Fly   312 HGLQCPKFRLDPDNFPDDSHTINPSNGSLIIHNTFKTYTNTQYCV---------ERVRPNQKLYT 367

  Fly   207 RRCYRN-VMPG---------IAQLSVISVVGFILTLAVYLSVEKLRNLLGKCLICSLFSMFMEYF 261
            ..|:.| |:.|         |..|  ||...:.|||.||:|:.|||||.||.|||.:.|:|..|.
  Fly   368 FLCFDNKVVTGDRIRFKMYPIGLL--ISCCFYALTLIVYISIAKLRNLPGKILICLVSSLFAAYL 430

  Fly   262 IWTMDYFRLLQS--ICSAAGYMKYFFSMSSYLWFSVVSFHLWELF-----TSLNRHEPQYRFLIY 319
            ...:...|...:  ||..:|:..||..|:::.|.::.||.:|:.|     .|..:.:.:.:|:.|
  Fly   431 GIALGQLRPTSNDDICFLSGFFVYFCLMAAFSWMNITSFDIWKTFGSTKLKSCEKSDLRRQFIWY 495

  Fly   320 NTFVWCTAAIPTV-----VIFSMNQMWENDPGKSEWL-----PLVGYFGC--SVKDWNSSSWFYS 372
            :.:.|   .:||:     :.|:          ||:.|     |..|:..|  :...:.|:|..:.
  Fly   496 SCYGW---GLPTLLTGITIAFT----------KSDILPDAVRPNFGHGRCWFTYDSFGSASLLFF 547

  Fly   373 HIPIVILNSFNVIMFVLTAIYIWKVKKGV--------------KSFAQHDERNTTCLEFNVQTYI 423
            ..|:.||...|:::||||..|..|||..:              :.|.|...|           ::
  Fly   548 SGPVGILFIINLVLFVLTMKYCNKVKNEIYKMQSLNSDKPVLKRRFFQDKTR-----------FV 601

  Fly   424 QFVRLFLIMGASWLLDQLTRLAEDSHLLLDTIVLNLTVYLNAAFGILIFVLLILKGSTFKMIM 486
            ...:|..:||.:|||:.::.|..|..   .|....::...|...||.:|::.:.|...:..||
  Fly   602 MNTKLCFVMGITWLLEIVSILFYDHK---KTFFWTISDSFNVLLGIFVFIIFVFKRRIYNEIM 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145	44/226 (19%)
mthl15	NP_723538.3	Mth_Ecto	<247..355	CDD:299804	29/129 (22%)
		7tm_4	385..646	CDD:304433	77/289 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I4416
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5395
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	1	1.000	-	-		FOG0003851
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47154
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.070