DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl12 and mthl14

DIOPT Version :9

Sequence 1:	NP_731791.2	Gene:	mthl12 / 261599	FlyBaseID:	FBgn0045442	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_728509.1	Gene:	mthl14 / 318046	FlyBaseID:	FBgn0052476	Length:	533	Species:	Drosophila melanogaster

Alignment Length:	528	Identity:	114/528 - (21%)
Similarity:	207/528 - (39%)	Gaps:	117/528 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 NSSAKIP----HCKYDETINISHFKRLN-------DAYIYEHFEIPANLTGEFDYKELMDGSKVP 72
            |:||:|.    ..|.....||.|....|       ||.|:....:|...:.|   ...:.|::..
  Fly    20 NASAQISTVNNSSKGSNNSNIFHEDTFNSTSIDVLDASIHSTLVVPQTYSTE---AATISGARFA 81

  Fly    73 TEFP-------NLRGCICKVR----------PCIRI--CCA--------RKNILSNGECSDGVKN 110
            |..|       .|....|..|          |..|:  ||.        |:| .|:..|.:|
  Fly    82 TSVPVQSPVDNPLDPADCSQREKYRKQPVATPSSRLRKCCPHGENLNIYREN-QSDSMCDNG--- 142

  Fly   111 EIKLTMLDLTMQDILLTDPTLAELNMIPQYNSTELLILREQFQPCDE--IVSLKRDEYTILKDGS 173
               |...:.|:...:|.|..:.:|.:       |..:..:...||:.  :...|.|.:.:|:|||
  Fly   143 ---LLSFEPTIISAVLFDNCIEDLEV-------ETTLDYDIGNPCNSSLLYDDKDDVFFVLQDGS 197

  Fly   174 ILLHTSAEILSNDQYCLYPEIYSDFPETIRIINRRCYRNV--------MPGIAQLSVISVVGFIL 230
            :|:   .:...|:.|.:......|..::..:....|...|        :..:|.|.:||:...:|
  Fly   198 LLI---IDKFGNESYTVKEHYCLDIDKSGHLFAFTCVTQVEEQIAFAKVVFVAVLMLISMPCLLL 259

  Fly   231 TLAVYLSVEKLRNLLGKCLICSLFSMFME--YFIWTMDYFRLLQSICSAA--GYMKYFFSMSSYL 291
            ...:::::..||||.|  |..||.|:.:.  ||:.::.:   :..|.:..  ||:..|..:|.:.
  Fly   260 VSYLHMTLRLLRNLHG--LSLSLMSLCLASGYFVHSVVH---IYGIPNQGFIGYVIQFCILSYFF 319

  Fly   292 WFSVVSF----HLW---ELFTSLNRHEPQYRFLIYNTFVWCTAAIPTVVIFSMNQMWENDPGKSE 349
            |:..:.|    ::|   ......::....:.|..|..|.:...|  |:|..::.   :..||
  Fly   320 WYLCICFNVLLNVWYKLPCCIQCSKSWATFNFACYAVFAFSGPA--TIVALTVQ---KGLPG--- 376

  Fly   350 WLPLVGYF--GCSVKDWNSSSWFYSHIPIVILNSF--NVIMFVLTAIYIWKVKKGVKSFAQHDER 410
               :..||  |.:....:|..:|...:..::..||  |:|.|    ....::....|:.....||
  Fly   377 ---MPSYFLQGLTESIRDSQRYFIPPVSTILFLSFLLNIISF----FGFQRISGYAKAEKNIQER 434

  Fly   411 NTTCLEFNVQTYIQFVR-------LFLIMGASWLLDQLTRLA-EDSHLLLDTIVLNLTVYLNAAF 467
            .  || |:.|.|....:       |.:||..||||:.:|..: .:|:.|   |:.::...|...:
  Fly   435 K--CL-FDQQKYEDVKKDAKCVSLLGIIMVVSWLLEIITFYSGSNSNYL---ILCDMVNGLQGVW 493

  Fly   468 GILIFVLL 475
            .:|||:::
  Fly   494 VLLIFLVV 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145	43/217 (20%)
mthl14	NP_728509.1	7tmB3_Methuselah-like	239..512	CDD:320167	65/289 (22%)
		TM helix 1	241..266	CDD:320167	5/24 (21%)
		TM helix 2	275..297	CDD:320167	7/26 (27%)
		TM helix 3	306..331	CDD:320167	6/24 (25%)
		TM helix 4	349..369	CDD:320167	6/21 (29%)
		TM helix 5	389..418	CDD:320167	7/32 (22%)
		TM helix 6	445..472	CDD:320167	8/26 (31%)
		TM helix 7	477..502	CDD:320167	7/28 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462172
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840