DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl12 and Adgrg6

DIOPT Version :9

Sequence 1:	NP_731791.2	Gene:	mthl12 / 261599	FlyBaseID:	FBgn0045442	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	XP_218313.7	Gene:	Adgrg6 / 308376	RGDID:	1308551	Length:	1248	Species:	Rattus norvegicus

Alignment Length:	448	Identity:	86/448 - (19%)
Similarity:	168/448 - (37%)	Gaps:	123/448 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 NDAYIYEHFE-----------IPANLTGEFDYKELMDGSKVPTEFPNLRGCICKVRPCIRICCAR 95
            ||:|....||           :|.||......::.:...:....|.|..|....|.      ..|
  Rat   702 NDSYFQMDFENGQADPLASVILPPNLLENLSPEDSILVRRAQFTFFNKTGLFQDVG------SQR 760

  Fly    96 KNILSN-GECSDGVKNEIKLTMLDLTMQDILLTDPTLAELNMIPQYNSTELLILREQFQPCDEIV 159
            |.::|. ..||.|          ::|:|:  |.||...::    ::..|:     |..||.....
  Rat   761 KILVSYVMACSIG----------NITIQN--LKDPVQIKI----KHTRTQ-----EVHQPICAFW 804

  Fly   160 SLKRDE-YTILKDGSILLHTSAEILSNDQYCL-----YPEIYSDFPETIRIINRRCYRNVMPGIA 218
            .|.::: :........:.|:.::  :.:..||     :..:..|.|.:...|:.| ...|:..|.
  Rat   805 DLNQNKSFGGWNTSGCVAHSDSD--AGETICLCNHFTHFGVLMDLPRSASQIDGR-NTKVLTFIT 866

  Fly   219 QLSV-ISVVGFILTLAVYLSVEKLRNLLGKCLICSLFS--MFMEYFI----WTMDYFRLLQSICS 276
            .:.. ||.:....||..|::.||||......::.:|.|  :|:....    |...:.  :..:|:
  Rat   867 YIGCGISAIFSAATLLTYVAFEKLRRDYPSKILMNLSSALLFLNLIFLLDGWITSFG--VAGLCT 929

  Fly   277 AAGYMKYFFSMSSYLWFSVVSFHLWELFTSLNRHEPQYRFLIYNTFV-----------W-CTAAI 329
            |...:.:||.::::.|..:.:.|::.....           ::||::           | ..|.:
  Rat   930 AVAALLHFFLLATFTWMGLEAIHMYIALVK-----------VFNTYIHRYILKFCIIGWGLPALV 983

  Fly   330 PTVVIFS--MNQMWENDP-GKSE-----WL--PLV------GYFGCSVKDWNSSSWFYSHIPIVI 378
            .::::.|  .|:::..:. ||.:     |:  |:|      ||||                   |
  Rat   984 VSIILVSRKQNEVYGKESYGKDQDDEFCWIQDPVVFYVSCAGYFG-------------------I 1029

  Fly   379 LNSFNVIMFVLTAIYIWKVKKGVKSFAQHDERNTTCLEFNVQTYIQFVRLFLIMGASW 436
            :...||.||::..:.|.. :.|.:|       |.|..|..::.....|.|..::|.:|
  Rat  1030 MFFLNVAMFIVVMVQICG-RNGKRS-------NRTLREEVLRNLRSVVSLTFLLGMTW 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145	34/184 (18%)
Adgrg6	XP_218313.7	CUB	38..146	CDD:238001
		LamG	178..337	CDD:304605
		GPS	799..844	CDD:280071	5/46 (11%)
		7tm_4	861..1108	CDD:304433	51/259 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810