DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl12 and Adgrg3

DIOPT Version :9

Sequence 1:	NP_731791.2	Gene:	mthl12 / 261599	FlyBaseID:	FBgn0045442	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	XP_038954076.1	Gene:	Adgrg3 / 291854	RGDID:	1305674	Length:	574	Species:	Rattus norvegicus

Alignment Length:	276	Identity:	51/276 - (18%)
Similarity:	111/276 - (40%)	Gaps:	50/276 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 SVISVVGFILTLAVYL----SVEKLRN----LLGKCLICSLFSMFMEYFIWTMDYFRLLQSICSA 277
            |.:|::....|:.:|:    |:::.::    .:...|..|||.:.:.:.|......:...:.|..
  Rat   303 SAVSMIFLAFTMVLYVAFRFSLQRFKSEDAPKIHMALSTSLFLLNLTFLINVGSGSQGPPASCWV 367

  Fly   278 AGYMKYFFSMSSYLWFSVVSFHLWELFTSL-NRHEPQYRFLIYNTFVWCTAAIPTVVIFSMNQMW 341
            ...:.::|.:..:.|..:.:|||:.|...: |.:...| ||..:...|   .:|.:::..:
  Rat   368 RAAIFHYFLLCVFTWMGLEAFHLYLLVIKVFNTYFGHY-FLKLSLLGW---GLPVLIVIGV---- 424

  Fly   342 ENDPGKSEWLPLVGYFGCSVKDWNSSS-----WFYSHIPI-VILNSFNVIMF----VLTAIYIWK 396
                |.|.     .|...:::|..:.:     ||.....: ..::.:.::.|    |:.|:..||
  Rat   425 ----GSSN-----SYGVYTIRDQENRTSLELCWFQKEPALYATVHGYFLVTFLFGAVVLAMVAWK 480

  Fly   397 VKKGVKSFAQHDERNTTCLEFNVQTYIQFVRLFLIMGASWLLDQLTRLAEDSHLLLDTIVLNLTV 461
            :.......|...:..|.      ::.:..:.|..::|.:|.|..||.|.      |.|:.  :..
  Rat   481 IFTLPSVTAGKGQGQTW------KSVLTVLGLSSLVGMTWGLAVLTPLG------LSTVY--IFT 531

  Fly   462 YLNAAFGILIFVLLIL 477
            .||:..|:.||...|:
  Rat   532 LLNSLQGLFIFCWFII 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145
Adgrg3	XP_038954076.1	GPS	244..282	CDD:396408
		7tm_GPCRs	292..551	CDD:421689	51/276 (18%)
		TM helix 1	294..319	CDD:410628	4/15 (27%)
		TM helix 2	333..355	CDD:410628	5/21 (24%)
		TM helix 3	366..393	CDD:410628	5/26 (19%)
		TM helix 4	406..426	CDD:410628	4/30 (13%)
		TM helix 5	454..481	CDD:410628	4/26 (15%)
		TM helix 6	495..522	CDD:410628	7/32 (22%)
		TM helix 7	524..549	CDD:410628	8/26 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810