DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl12 and ADGRF1

DIOPT Version :9

Sequence 1:	NP_731791.2	Gene:	mthl12 / 261599	FlyBaseID:	FBgn0045442	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_722582.2	Gene:	ADGRF1 / 266977	HGNCID:	18990	Length:	910	Species:	Homo sapiens

Alignment Length:	552	Identity:	102/552 - (18%)
Similarity:	193/552 - (34%)	Gaps:	154/552 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IVTIAKN--SSAKIPHC-------KYD-----ETINISHFKRLNDAYIYEHFEIPANLTGEFDYK 63
            :::||.|  :||.:.:.       ||.     ||:.       |.:.:.....:|.|.:.:|
Human   374 VISIADNILNSASVTNWTVLLREEKYASSRLLETLE-------NISTLVPPTALPLNFSRKF--- 428

  Fly    64 ELMDGSKVPTEFPNL-RGCICKVRPC-----IRICCARKNILSNGECSDGVKNEIKLTMLDLTMQ 122
              :|...:|.....| ||...:::.|     |.|   |..:|...:.......|..::|..||:.
Human   429 --IDWKGIPVNKSQLKRGYSYQIKMCPQNTSIPI---RGRVLIGSDQFQRSLPETIISMASLTLG 488

  Fly   123 DIL---------LTDPTLAELNMIPQYNSTELLILREQFQPCDEIVSLKRDEYTILKDGSILLHT 178
            :||         :..|.::  .:|..|:..|:.:.      ..:|.|.....:.:..|.|
Human   489 NILPVSKNGNAQVNGPVIS--TVIQNYSINEVFLF------FSKIESNLSQPHCVFWDFS----- 540

  Fly   179 SAEILSNDQYCLYPEIYSDFPETIRIINRRC-----YRNVMPGIAQLSVISVVGFILTLAVYLSV 238
              .:..||..|....      ||..|:..:|     :..:|......::..||.:|..:.:.:|:
Human   541 --HLQWNDAGCHLVN------ETQDIVTCQCTHLTSFSILMSPFVPSTIFPVVKWITYVGLGISI 597

  Fly   239 EKLRNLLGKCLICSLFSMFMEYFIW----------------------------------TMDYFR 269
                   |..::|    :.:|...|                                  |:|...
Human   598 -------GSLILC----LIIEALFWKQIKKSQTSHTRRICMVNIALSLLIADVWFIVGATVDTTV 651

  Fly   270 LLQSICSAAGYMKYFFSMSSYLWFSVVSFHLWELFTSLNRHEPQYRFLIYNTFVWCTA----AIP 330
            ....:|:||.:..:||.:|.:.|..::...|......:..|..|:..:...   :|..    .|.
Human   652 NPSGVCTAAVFFTHFFYLSLFFWMLMLGILLAYRIILVFHHMAQHLMMAVG---FCLGYGCPLII 713

  Fly   331 TVVIFSMNQMWENDPGKSE-WLPLVGYFGCSVKDWNSSS-----WFYSHIPIVILNSFNVIMFVL 389
            :|:..::.|.......|.. ||           :|::.|     :....:.||.:| |.|::.||
Human   714 SVITIAVTQPSNTYKRKDVCWL-----------NWSNGSKPLLAFVVPALAIVAVN-FVVVLLVL 766

  Fly   390 TAIYIWKVKKGVKSFAQHDERNTTCLEFNVQTYIQFVRLFLIMGASWLLDQLTRLAEDSHLLLDT 454
            |.  :|:...|.:  ...|::.|.     ::.....:.|..::|.:|.....|.:  ||..|...
Human   767 TK--LWRPTVGER--LSRDDKATI-----IRVGKSLLILTPLLGLTWGFGIGTIV--DSQNLAWH 820

  Fly   455 IVLNLTVYLNAAFGILIFVLLILKGSTFKMIM 486
            ::..|   |||..|..|....||..|..:.::
Human   821 VIFAL---LNAFQGFFILCFGILLDSKLRQLL 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145	38/208 (18%)
ADGRF1	NP_722582.2	SEA	154..>215	CDD:279699
		GPS	532..572	CDD:280071	9/52 (17%)
		7tm_4	582..834	CDD:304433	53/291 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900