DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl12 and Adgrf5

DIOPT Version :9

Sequence 1:NP_731791.2 Gene:mthl12 / 261599 FlyBaseID:FBgn0045442 Length:488 Species:Drosophila melanogaster
Sequence 2:XP_038938942.1 Gene:Adgrf5 / 245977 RGDID:621679 Length:1426 Species:Rattus norvegicus


Alignment Length:272 Identity:53/272 - (19%)
Similarity:90/272 - (33%) Gaps:104/272 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   220 LSVISVVGF---ILTLAVYLSVEK-------------LRNLLGKCLI----CSLFSMFMEYFIWT 264
            |.:||.:|.   |::||..|.||.             :|::   |::    |.|.:     .||.
  Rat  1092 LDIISYIGLGFSIVSLAACLVVEAMVWKSVTKNRTSYMRHI---CIVNIALCLLIA-----DIWF 1148

  Fly   265 M-------DYFRLLQSICSAAGYMKYFFSMSSYLWFSVVSFHLWE--LFTSLNRHEPQYRFLIYN 320
            :       .::.|.::.|.||.:..:||.:|.:.|...:...|:.  :|...:..:...:.:.::
  Rat  1149 IVAGAIHDGHYPLNETACVAATFFIHFFYLSVFFWMLTLGLMLFYRLIFILHDASKSTQKAIAFS 1213

  Fly   321 TFVWCTAAI---------PTVVIFSMNQMWEN--------------------------------- 343
            ....|...|         |..|....|..|.|                                 
  Rat  1214 LGYGCPLIISSITVGVTQPQEVYMRKNACWLNWEDTRALLAFAIPALIIVVVNVSITVVVITKIL 1278

  Fly   344 ------DPGKSE-------------WLPLVGY---FGCSVKDWNSSSWFYSHIPIVILNSFNVIM 386
                  .|||.|             ..||:|.   ||.:.....|::.|  ||...:||:|.. :
  Rat  1279 RPSVGDKPGKQEKSSLFQISKSIGVLTPLLGLTWGFGLATVIQGSNAVF--HIIFTLLNAFQG-L 1340

  Fly   387 FVLTAIYIWKVK 398
            |:|....:|..|
  Rat  1341 FILLFGCLWDQK 1352

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl12NP_731791.2 Methuselah_N 27..209 CDD:284145
Adgrf5XP_038938942.1 FR3 592..622 CDD:409353
Ig strand E 602..608 CDD:409353
Ig strand F 616..623 CDD:409353
CDR3 623..632 CDD:409353
GPS 1029..1076 CDD:396408
7tm_GPCRs 1090..1363 CDD:421689 53/272 (19%)
TM helix 1 1091..1116 CDD:410628 10/23 (43%)
TM helix 2 1131..1153 CDD:410628 5/29 (17%)
TM helix 3 1167..1190 CDD:410628 6/22 (27%)
TM helix 4 1210..1226 CDD:410628 2/15 (13%)
TM helix 5 1248..1271 CDD:410628 0/22 (0%)
TM helix 6 1295..1320 CDD:410628 5/24 (21%)
TM helix 7 1325..1350 CDD:410628 8/27 (30%)
SEA 181..273 CDD:396113
IG 298..372 CDD:214652
Ig_3 548..621 CDD:404760
FR1 548..567 CDD:409353
Ig strand A 548..551 CDD:409353
Ig strand A' 555..557 CDD:409353
Ig strand B 561..568 CDD:409353
CDR1 568..575 CDD:409353
Ig strand D 591..598 CDD:409353
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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