Protein Alignment mthl12 and Adgrd1

DIOPT Version :9

• Sequence 1: NP_731791.2
• Gene: mthl12 / 261599
• FlyBaseID: FBgn0045442
• Length: 488
• Species: Drosophila melanogaster
• Sequence 2: NP_001074811.1
• Gene: Adgrd1 / 243277
• MGIID: 3041203
• Length: 903
• Species: Mus musculus
• Alignment Length: 545
• Identity: 105/545 - (19%)
• Similarity: 172/545 - (31%)
• Gaps: 174/545 - (31%)

  Fly    16 IAKNSSAKIPHCKYDETINISHF---KRLNDAYIYEHFEIPAN---------------------- 55
            |:.|..::.||.....:.:.:.|   |.|..|....|:..||:
Mouse   390 ISSNLQSREPHVTLTGSSSTAEFTVAKVLPPALSAPHYRFPAHGHSYIEIPREALHSQAWTTIVG 454

  Fly    56 ---LTGEFDYKELMDGSKVPTEFP---NLRGCICKV---------------------RPCIRICC 93
               .|..:..|.:...|   ||.|   |.|.|:..|                     .|.|.:..
Mouse   455 LLYHTMHYYLKNIHPTS---TEIPEAVNCRDCLLSVASHLISLEVSPPPTLSQNLSGSPLITVHL 516

  Fly    94 ARKNILSNGECSDGVKNEIKL----TMLDL-------TMQDILLTDPTLAELNMIPQYNSTELLI 147
            ..|  |:..:.||......:|    ..|:.       :.|...||:..|. .::....:.|...|
Mouse   517 RHK--LTQKQYSDATNESNRLFLYCAFLNFSSGEGVWSSQGCALTEGNLT-YSVCHCTHLTNFAI 578

  Fly   148 LREQFQPCDEIVSLKRDEYTILKDGSILLHTSAEILSNDQY--CLYPEIYSDFPETIRIINRRCY 210
            |.       ::|.||            |.|.....||:..|  |
Mouse   579 LM-------QVVPLK------------LTHGHQVALSSISYVGC--------------------- 603

  Fly   211 RNVMPGIAQLSVISVVGFILTLAVYLSVEKLRN-------------LLGKCLICSLFSMFMEYFI 262
                    .|||:.:...::|.||..||..:||             |:.:.|:...|||..
Mouse   604 --------SLSVLCLAATLVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQVLLLISFSMEP---- 656

  Fly   263 WTMDYFRLLQSICSAAGYMKYFFSMSSYLWFSVVSFHLWELFTSLNRHEPQYRFLIYNTFVW-CT 326
            .|:.        |.....:.::|.::::.|..|...||:.:...:...|.. :.|.|....| |.
Mouse   657 GTVP--------CQVLAVLLHYFFLTAFAWMLVEGLHLYSMVIKVFGSEDS-KHLYYYGIGWGCP 712

  Fly   327 AAIPTVVI-FSMNQMWENDPGKSEWLPLVGYFGCSVKDWNSSSWFYSHIPIVILNSFNVIMFVLT 390
            ..|..:.| .||:....:|   |.||.|          .:.:.|.:.. |.:::...|:::.|..
Mouse   713 LLICIISISSSMDSYGTSD---SCWLAL----------GSGAIWAFVG-PALLVIVVNIVILVAV 763

  Fly   391 AIYIWKVKKGVKSFAQHDERNTTCLEFNVQTYIQFVRLFLIMGASWLLDQLTRLAEDSHLLLDTI 455
            ...|..:  ...|:..|.:.:...|     |......|..|:|.||:...|.  ..|..|:..
Mouse   764 TRVISHI--STDSYKIHGDPSAFKL-----TAKAVAVLLPILGTSWVFGVLA--VSDRALVFQ-- 817

  Fly   456 VLNLTVYLNAAFGILIFVLLILKGS 480
              .:...||:..|:.||:...|..|
Mouse   818 --YMFAILNSLQGLFIFLFHCLLNS 840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145	41/246 (17%)
Adgrd1	NP_001074811.1	Laminin_G_3	<173..273	CDD:290121
		GPS	539..579	CDD:280071	6/40 (15%)
		Stachel. /evidence=ECO:0000250|UniProtKB:Q6QNK2	575..583		2/14 (14%)
		7tm_4	595..831	CDD:304433	60/304 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	862..903

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810