DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl12 and Adgrg7

DIOPT Version :9

Sequence 1:	NP_731791.2	Gene:	mthl12 / 261599	FlyBaseID:	FBgn0045442	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_766413.2	Gene:	Adgrg7 / 239853	MGIID:	2441732	Length:	785	Species:	Mus musculus

Alignment Length:	330	Identity:	60/330 - (18%)
Similarity:	133/330 - (40%)	Gaps:	76/330 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 FPETIRIINRRCYRNVMPGIAQLSVISVVGFILTLAVYLSVEKLRN------LLGKCLICSLFSM 256
            :|:::.|::     |:  |.|    :|:.|..||:...:...|:|.      |:..|....:|::
Mouse   427 YPKSLDILS-----NI--GCA----LSIAGLALTILFQILTRKIRKTSVTWVLVSLCSSMLIFNL 480

  Fly   257 FMEYFIWT-----------------------MDYFRLLQSICSAAGYMKYFFSMSSYLWFSVVSF 298
            ...:.|..                       .|........|:|...:.::|.:.::.|..:.:.
Mouse   481 LFVFGIENSNKNLKTSDSDINVKPENNKIPESDTIETPNPSCTAIAALLHYFLLVTFTWNGLSAT 545

  Fly   299 HLWELFTSLNRHEPQYRFLIYNTFV-WCTAAIPTVV-------IFSMN---QMWENDPGKSE--W 350
            .|:.|.....:..|:: |:|:.:.| |   .:|.::       |::::   :.||.|..:.|  |
Mouse   546 QLYFLLIRTMKPLPRH-FIIFISLVGW---GVPAIIVGVTIGSIYALSGNKRYWELDYRQEEICW 606

  Fly   351 LPLVGYFGCSVKDWNSSSWFYSH-IPIVILNSFNVIMFV-LTAIYIWKVKKGVKSFAQHDERNTT 413
            |.:.     ...|:..|...:|. ||:.|:...|:.:|| :|...:||..:.:.|         |
Mouse   607 LAVP-----KDNDYARSPLLWSFIIPVTIILITNITIFVIITVKVLWKNNQNLTS---------T 657

  Fly   414 CLEFNVQTYIQFVRLFLIMGASWLLDQLTRLAEDSHLLLDTIVLNLTVYLNAAFGILIFVLLILK 478
            ....:::.....:.:.::.|.:|:|.....::.|...::.:.:..|   .|...|:.||:|..::
Mouse   658 KKVSSLKKVFSTLSIAVVFGVTWILAYAMLISNDDIRIVFSYIFCL---FNTTQGLQIFILYTVR 719

  Fly   479 GSTFK 483
            ...|:
Mouse   720 TKVFQ 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145	2/10 (20%)
Adgrg7	NP_766413.2	GPS	380..418	CDD:280071
Adgrg7	NP_766413.2	7tm_4	430..710	CDD:304433	54/311 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900