DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl12 and ADGRL3

DIOPT Version :9

Sequence 1:	NP_731791.2	Gene:	mthl12 / 261599	FlyBaseID:	FBgn0045442	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	XP_016863418.1	Gene:	ADGRL3 / 23284	HGNCID:	20974	Length:	1586	Species:	Homo sapiens

Alignment Length:	273	Identity:	61/273 - (22%)
Similarity:	103/273 - (37%)	Gaps:	47/273 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 LSVISVVGFILTLAVYL----------SVEKLRNLLGKCLICSLFSMFMEYFIWTMDYFRLLQSI 274
            |.||:.||.:|:|...|          .::..||.:.|.|..||   |:...::.:...|..|.|
Human   945 LDVITWVGILLSLVCLLICIFTFCFFRGLQSDRNTIHKNLCISL---FVAELLFLIGINRTDQPI 1006

  Fly   275 -CSAAGYMKYFFSMSSYLWFSVVSFHLWELFTSLNRHEPQYRFLIYNTFVWCTAAIPTVVIFSMN 338
             |:....:.:||.::::.|..:....|:.:...:...|...|...|.......|.|..|......
Human  1007 ACAVFAALLHFFFLAAFTWMFLEGVQLYIMLVEVFESEHSRRKYFYLVGYGMPALIVAVSAAVDY 1071

  Fly   339 QMWENDPGKSEWLPLVGYFGCSVKDWNSSSWFYSHI-PIVILNSFNVIMFVLTAIY-------IW 395
            :.:..|  |..||.|..||            .:|.| |..::...||| |:..|:|       |.
Human  1072 RSYGTD--KVCWLRLDTYF------------IWSFIGPATLIIMLNVI-FLGIALYKMFHHTAIL 1121

  Fly   396 KVKKGVKSFAQHDERNTTCLEFNVQTYIQFVRLFLIMGASWLLDQLTRLAEDSHLLLDTIVLNLT 460
            |.:.|......:::..    .|.....|..:.|..::|.:|... |..:.|.:     .|:..|.
Human  1122 KPESGCLDNINYEDNR----PFIKSWVIGAIALLCLLGLTWAFG-LMYINEST-----VIMAYLF 1176

  Fly   461 VYLNAAFGILIFV 473
            ...|:..|:.||:
Human  1177 TIFNSLQGMFIFI 1189

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145
ADGRL3	XP_016863418.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810