DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl12 and ADGRL2

DIOPT Version :9

Sequence 1:	NP_731791.2	Gene:	mthl12 / 261599	FlyBaseID:	FBgn0045442	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_001352934.1	Gene:	ADGRL2 / 23266	HGNCID:	18582	Length:	1469	Species:	Homo sapiens

Alignment Length:	275	Identity:	62/275 - (22%)
Similarity:	113/275 - (41%)	Gaps:	60/275 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 LSVISVVGFIL----------TLAVYLSVEKLRNLLGKCLICSLFSMFMEYFIWTMDYFRLLQSI 274
            |:||:.||.::          |...:..::..||.:.|.|..:|   |:..||:.:...:...:|
Human   851 LTVITWVGIVISLVCLAICIFTFCFFRGLQSDRNTIHKNLCINL---FIAEFIFLIGIDKTKYAI 912

  Fly   275 -CSAAGYMKYFFSMSSYLWFSVVSFHLW----ELFTSLNRHEPQY---RFLIYNTFVWCTAAIPT 331
             |.....:.:||.::::.|..:....|:    |:|.|....:..|   .:|...|.|..:|||
Human   913 ACPIFAGLLHFFFLAAFAWMCLEGVQLYLMLVEVFESEYSRKKYYYVAGYLFPATVVGVSAAI-- 975

  Fly   332 VVIFSMNQMWENDPGKSEWLPLVGYFGCSVKDWNSSSWFYSHIPIVILNSFNVIMFVLTAIYIWK 396
                   ........|:.||.:..||     .|:    |...:..:||  .|:|..|:|...:.|
Human   976 -------DYKSYGTEKACWLHVDNYF-----IWS----FIGPVTFIIL--LNIIFLVITLCKMVK 1022

  Fly   397 VKKGVKSFAQHDERNTTCLEFNVQTYI--QFVRLFLIMGASWLLDQLTRLAEDSHLLLDTIVL-N 458
            ....:|.       :::.|| |:::::  .|. |..::|.:|....|       .:..:|||: .
Human  1023 HSNTLKP-------DSSRLE-NIKSWVLGAFA-LLCLLGLTWSFGLL-------FINEETIVMAY 1071

  Fly   459 LTVYLNAAFGILIFV 473
            |....||..|:.||:
Human  1072 LFTIFNAFQGVFIFI 1086

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145
ADGRL2	NP_001352934.1	Gal_Lectin	49..129	CDD:307994
		OLF	142..398	CDD:321983
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	426..460
		HormR	469..533	CDD:214468
		GAIN	542..764	CDD:318649
		GPS	788..840	CDD:197639
		7tmB2_Latrophilin-2	848..1105	CDD:320672	62/275 (23%)
		TM helix 1	850..875	CDD:320672	6/23 (26%)
		TM helix 2	884..906	CDD:320672	7/24 (29%)
		TM helix 3	915..942	CDD:320672	4/26 (15%)
		TM helix 4	954..974	CDD:320672	4/19 (21%)
		TM helix 5	991..1020	CDD:320672	10/39 (26%)
		TM helix 6	1036..1063	CDD:320672	6/34 (18%)
		TM helix 7	1067..1092	CDD:320672	8/20 (40%)
		Latrophilin	1104..1469	CDD:308136
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1368..1410
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810